BLASTP 2.0.10 [Aug-26-1999] 

Query= XF-11A03-GL52
         (172 letters)

Database: nr
           457,798 sequences; 140,871,481 total letters

Graphical Overview:

                                                                Score     E
Sequences producing significant alignments:                     (bits)  Value

gi|1073802|pir||C64046 7,8-dihydro-6-hydroxymethylpterin-pyroph...   147    6e-35
gi|1170357|sp|P43777|HPPK_HAEIN 2-AMINO-4-HYDROXY-6-HYDROXYMETH...   144    4e-34
gi|5542271|pdb|1HKA|  6-Hydroxymethyl-7,8-Dihydropterin Pyropho...   132    1e-30
gi|123493|sp|P26281|HPPK_ECOLI 2-AMINO-4-HYDROXY-6-HYDROXYMETHY...   132    1e-30
gi|6016252|sp|P72736|HPPK_SYNY3 2-AMINO-4-HYDROXY-6-HYDROXYMETH...   123    9e-28
gi|6016250|sp|O87790|HPPK_PSEPU 2-AMINO-4-HYDROXY-6-HYDROXYMETH...   122    2e-27
gi|4808340|emb|CAB42754.1| (AL049841) putative hydroxymethyldih...   122    2e-27
gi|6016246|sp|P71512|HPPK_METEX 2-AMINO-4-HYDROXY-6-HYDROXYMETH...   121    3e-27
gi|6457838|gb|AAF09758.1|AE001879_6 (AE001879) 2-amino-4-hydrox...   116    1e-25
gi|585263|sp|P29252|HPPK_BACSU 2-AMINO-4-HYDROXY-6-HYDROXYMETHY...   113    8e-25
gi|98370|pir||F37854 folate biosynthesis protein 2 (sul 3' regi...   113    8e-25
gi|3970811|emb|CAA10221| (AJ130846) 7,8-dihydro-6-hydroxymethyl...   111    4e-24
gi|4980526|gb|AAD35135.1|AE001691_9 (AE001691) 2-amino-4-hydrox...    98    6e-20
gi|6175071|sp|P22291|SULD_STRPN BIFUNCTIONAL FOLATE SYNTHESIS P...    92    4e-18
gi|3738161|emb|CAA21297.1| (AL031856) dihydropteroate synthase ...    88    4e-17
gi|6016244|sp|O66550|HPPK_AQUAE 2-AMINO-4-HYDROXY-6-HYDROXYMETH...    88    4e-17
gi|119838|sp|P29251|FAS_PNECA FOLIC ACID SYNTHESIS PROTEIN [INC...    86    2e-16
gi|6016249|sp|O83019|HPPK_PORGI 2-AMINO-4-HYDROXY-6-HYDROXYMETH...    76    1e-13
gi|98011|pir||A36704 2-amino-4-hydroxy-6-hydroxymethyldihydropt...    75    5e-13
gi|4938476|emb|CAB43835.1| (AL078464) dihydropteroate synthase-...    75    5e-13
gi|6324073|ref|NP_014143.1|FOL1| dihydroneopterin aldolase, dih...    74    7e-13
gi|1934972|emb|CAA69903| (Y08611) dihydropterin pyrophosphokina...    73    2e-12
gi|6016248|sp|O06276|HPPK_MYCTU 2-AMINO-4-HYDROXY-6-HYDROXYMETH...    69    2e-11
gi|6016247|sp|O69528|HPPK_MYCLE 2-AMINO-4-HYDROXY-6-HYDROXYMETH...    67    9e-11
gi|6730646|gb|AAF27067.1|AC008262_16 (AC008262) F4N2.15 [Arabid...    66    2e-10
gi|6016251|sp|O33726|HPPK_STRPY 2-AMINO-4-HYDROXY-6-HYDROXYMETH...    65    5e-10
gi|6967563|emb|CAB72552.1| (AL139074) putative 2-amino-4-hydrox...    62    2e-09
gi|4154911 (AE001473) 7, 8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPH...    61    9e-09
gi|6016245|sp|O25680|HPPK_HELPY 2-AMINO-4-HYDROXY-6-HYDROXYMETH...    60    1e-08
gi|3329058|gb|AAC68216.1| (AE001331) Dihydropteroate Synthase [...    54    7e-07
gi|4377065|gb|AAD18896| (AE001657) Dihydropteroate Synthase [Ch...    48    5e-05
gi|2114408 (U81497) hydroxymethyldihydropterin pyrophosphokinas...    41    0.005
gi|2731631 (U61852) hydroxymethyldihydropterin pyrophosphokinas...    41    0.005
gi|3328792|gb|AAC67964.1| (AE001310) Chorismate Synthase [Chlam...    32    3.2
gi|1125755 (U42833) coded for by C. elegans cDNA yk38h3.5; code...    32    4.2
gi|6742658|gb|AAF15969.2|AF109736_1 (AF109736) O-antigen polyme...    31    9.5

>gi|1073802|pir||C64046
           7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
           (folK) homolog - Haemophilus influenzae (strain Rd KW20)
           Length = 168
           
 Score =  147 bits (367), Expect = 6e-35
 Identities = 77/156 (49%), Positives = 103/156 (65%), Gaps = 2/156 (1%)

Query: 6   SRVTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEF 65
           SR+    + AY+ LG+NL      L AA+ A+ QL  T L   SS Y++ P G QDQ ++
Sbjct: 3   SRIREKMITAYIALGSNLNTPVEQLHAALKAISQLSNTHLVTTSSFYKSKPLGPQDQPDY 62

Query: 66  VNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLR 125
           VNAVA +ET L+PL LLD L  +E   GRVRL   RWG RTLDLD+LLYG +++   RL 
Sbjct: 63  VNAVAKIETELSPLKLLDELQRIENEQGRVRL--RRWGERTLDLDILLYGNEIIQNERLT 120

Query: 126 VPHPHLHVRAFVVVPLAEIAAELVLPRHGMVCELLE 161
           +PH  +H R FV+VPL EIA++LVLP   ++ EL++
Sbjct: 121 IPHYDMHNREFVIVPLFEIASDLVLPNSQIITELVK 156


>gi|1170357|sp|P43777|HPPK_HAEIN
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|1573012 (U32691)
           2-amino-4-hydroxy-6-hydroxymethyldihydropteridine-
           pyrophosphokinase (folK) [Haemophilus influenzae Rd]
           Length = 160
           
 Score =  144 bits (360), Expect = 4e-34
 Identities = 75/149 (50%), Positives = 100/149 (66%), Gaps = 2/149 (1%)

Query: 13  VVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAAL 72
           + AY+ LG+NL      L AA+ A+ QL  T L   SS Y++ P G QDQ ++VNAVA +
Sbjct: 2   ITAYIALGSNLNTPVEQLHAALKAISQLSNTHLVTTSSFYKSKPLGPQDQPDYVNAVAKI 61

Query: 73  ETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLH 132
           ET L+PL LLD L  +E   GRVRL   RWG RTLDLD+LLYG +++   RL +PH  +H
Sbjct: 62  ETELSPLKLLDELQRIENEQGRVRL--RRWGERTLDLDILLYGNEIIQNERLTIPHYDMH 119

Query: 133 VRAFVVVPLAEIAAELVLPRHGMVCELLE 161
            R FV+VPL EIA++LVLP   ++ EL++
Sbjct: 120 NREFVIVPLFEIASDLVLPNSQIITELVK 148


>gi|5542271|pdb|1HKA|  6-Hydroxymethyl-7,8-Dihydropterin
           Pyrophosphokinase
           Length = 158
           
 Score =  132 bits (330), Expect = 1e-30
 Identities = 69/147 (46%), Positives = 95/147 (63%), Gaps = 1/147 (0%)

Query: 14  VAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALE 73
           VAY+ +G+NL      + AA+ AL  +P + +   SS YRTPP G QDQ +++NA  ALE
Sbjct: 2   VAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALE 61

Query: 74  TGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHV 133
           T LAP  LL+    +E   GRVR   +RWGPRTLDLD++L+G +V++  RL VPH  +  
Sbjct: 62  TSLAPEELLNHTQRIELQQGRVR-KAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKN 120

Query: 134 RAFVVVPLAEIAAELVLPRHGMVCELL 160
           R F++ PL EIA ELV P   M+ ++L
Sbjct: 121 RGFMLWPLFEIAPELVFPDGEMLRQIL 147


>gi|123493|sp|P26281|HPPK_ECOLI
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|321783|pir||A43325
           2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
           pyrophosphokinase (EC 2.7.6.3) - Escherichia coli
           >gi|146013 (L06495) hydroxymethyldihydropterin
           pyrophosphokinase [Escherichia coli]
           >gi|473801|dbj|BAA05590| (D26562)
           '7,8-dihydro-6-hydroxymethylpterin-pyrophosphoki nase'
           [Escherichia coli] >gi|1786335 (AE000123)
           7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase
           [Escherichia coli]
           Length = 159
           
 Score =  132 bits (330), Expect = 1e-30
 Identities = 69/147 (46%), Positives = 95/147 (63%), Gaps = 1/147 (0%)

Query: 14  VAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALE 73
           VAY+ +G+NL      + AA+ AL  +P + +   SS YRTPP G QDQ +++NA  ALE
Sbjct: 3   VAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALE 62

Query: 74  TGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHV 133
           T LAP  LL+    +E   GRVR   +RWGPRTLDLD++L+G +V++  RL VPH  +  
Sbjct: 63  TSLAPEELLNHTQRIELQQGRVR-KAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKN 121

Query: 134 RAFVVVPLAEIAAELVLPRHGMVCELL 160
           R F++ PL EIA ELV P   M+ ++L
Sbjct: 122 RGFMLWPLFEIAPELVFPDGEMLRQIL 148


>gi|6016252|sp|P72736|HPPK_SYNY3
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|1651824|dbj|BAA16751|
           (D90900) 7,
           8-dihydro-6-hydroxymethylpterin-pyrophosphoki nase
           [Synechocystis sp.]
           Length = 195
           
 Score =  123 bits (306), Expect = 9e-28
 Identities = 68/158 (43%), Positives = 96/158 (60%), Gaps = 4/158 (2%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALET 74
           A VGLG N+GP    L+ AIA L  +    +   SS YR+  +G   Q +++N    L  
Sbjct: 16  AVVGLGGNIGPVLDNLQGAIAELALVAGIEVERCSSWYRSRAFG-PPQPDYINGCVTLRV 74

Query: 75  GLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVR 134
            L+P  LL  LL +E   GR+RL  ++WGPRTLDLDL+ YG++ L+  RL +PHP +  R
Sbjct: 75  SLSPPELLQTLLAIEQKFGRIRL--EKWGPRTLDLDLIFYGDRQLEQARLTIPHPQMQYR 132

Query: 135 AFVVVPLAEIAAELVLPRHG-MVCELLEHIDTLGLVPI 171
            FV+VPLAEIA + V PR G  + +L+E +D   + P+
Sbjct: 133 PFVLVPLAEIAPDWVDPRSGKTIIQLIEQVDCTAVWPV 170


>gi|6016250|sp|O87790|HPPK_PSEPU
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|3650361|emb|CAA77046|
           (Y18131) 2-amino-4-hydroxy-6-
           hydroxymethyldihydropteridine pyrophosphokinase
           [Pseudomonas putida]
           Length = 120
           
 Score =  122 bits (303), Expect = 2e-27
 Identities = 68/118 (57%), Positives = 82/118 (68%), Gaps = 3/118 (2%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALET 74
           AYVGLG+NL      LR+A  ALDQ+  TRL  AS+LY +       Q  + NAVAAL+T
Sbjct: 5   AYVGLGSNLDSPAEQLRSAFQALDQVEATRLVAASALYTSDSL-LPGQPXYTNAVAALDT 63

Query: 75  GLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLH 132
            LAPLALLDAL  +E   G VR   +RWGPRTLDLD+LL+ +QVLD PRL+VPH H+H
Sbjct: 64  ALAPLALLDALQAIENDQGXVRK--ERWGPRTLDLDILLFSDQVLDQPRLKVPHYHMH 119


>gi|4808340|emb|CAB42754.1| (AL049841) putative
           hydroxymethyldihydropteridine pyrophosphokinase
           [Streptomyces coelicolor]
           Length = 203
           
 Score =  122 bits (303), Expect = 2e-27
 Identities = 70/158 (44%), Positives = 90/158 (56%), Gaps = 4/158 (2%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWG--RQDQAEFVNAVAAL 72
           A V LGANLG    TL+ AI AL+  P  R++  S +Y T PWG     Q  + NAV  L
Sbjct: 38  AVVALGANLGNRLETLQGAIDALEDTPGVRVKGVSPVYETEPWGVAPDSQPSYFNAVVIL 97

Query: 73  ETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLH 132
           +T L P +LL+    VE    RVR   +RWGPRTLD+D++ Y E V D P L +PHP  H
Sbjct: 98  KTTLPPSSLLERAHAVEEAFHRVR--DERWGPRTLDVDIVAYAEVVSDDPHLTLPHPRAH 155

Query: 133 VRAFVVVPLAEIAAELVLPRHGMVCELLEHIDTLGLVP 170
            RAFV+ P  ++  E  LP  G V +LL  +   G+ P
Sbjct: 156 ERAFVLAPWLDVDPEAALPGRGRVADLLAAVTRDGVAP 193


>gi|6016246|sp|P71512|HPPK_METEX
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|2160683 (U72662)
           6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
           [Methylobacterium extorquens]
           Length = 158
           
 Score =  121 bits (301), Expect = 3e-27
 Identities = 73/155 (47%), Positives = 94/155 (60%), Gaps = 5/155 (3%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALET 74
           AY+GLG+N+G     L  A+  L   P  R+   S+ YRTPPWG  DQ  F+NA  A++T
Sbjct: 4   AYLGLGSNIGDKAAMLAGAVEHLAATPGIRVVARSADYRTPPWGDTDQDWFLNAAVAIDT 63

Query: 75  GLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLY-GEQVLDLPRLRVPHPHLHV 133
            L P  LL+  L +E   GRVR P  RWGPR +D+D+L Y G QV D  RL +PH  +  
Sbjct: 64  ELTPHGLLEVCLSIEAALGRVREP--RWGPRVIDIDVLAYEGAQVSD-ERLVLPHRFVRE 120

Query: 134 RAFVVVPLAEIAAELVLPRHGMVCELLEHIDTLGL 168
           RAFV+VPLAEIA +LV+     V E L  +D  G+
Sbjct: 121 RAFVLVPLAEIAPDLVIGGE-TVREALAKLDPSGI 154


>gi|6457838|gb|AAF09758.1|AE001879_6 (AE001879)
           2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
           pyrophosphokinase [Deinococcus radiodurans]
           Length = 171
           
 Score =  116 bits (288), Expect = 1e-25
 Identities = 72/156 (46%), Positives = 93/156 (59%), Gaps = 6/156 (3%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPP-WGRQDQAEFVNAVAALE 73
           A++ LGANLG  + TLR A+  L  L    +R  S+LYRT P  G   Q +++NAVA LE
Sbjct: 4   AFIALGANLGDPQATLRRALTELGALG--EVRGVSALYRTAPVGGPPGQPDYLNAVAELE 61

Query: 74  TGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHV 133
           T L+  ALL AL  +E   GR R    RW  R LDLDL++YGE V D P L +PHP    
Sbjct: 62  TALSAPALLAALHALEADAGRTR--DVRWEARVLDLDLIVYGEDVSDDPALTLPHPRAWE 119

Query: 134 RAFVVVPLAEIAAELVLPRHG-MVCELLEHIDTLGL 168
           R FV+ PL+++A  L  PR G MV + L  +D  G+
Sbjct: 120 RGFVLAPLSDLAPSLAHPRTGEMVAQALRRVDLAGV 155


>gi|585263|sp|P29252|HPPK_BACSU
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|2126878|pir||S66109
           8-dihydro-6-hydroxymethylpterin-pyrophosphokinase -
           Bacillus subtilis >gi|467468|dbj|BAA05314| (D26185)
           7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin ase
           [Bacillus subtilis] >gi|2632346|emb|CAB11855| (Z99104)
           7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
           [Bacillus subtilis]
           Length = 167
           
 Score =  113 bits (281), Expect = 8e-25
 Identities = 58/137 (42%), Positives = 84/137 (60%), Gaps = 2/137 (1%)

Query: 12  NVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAA 71
           N +AY+ LG+N+G  E  LR A+A L Q     +   SS+Y T P G +DQA+F+N    
Sbjct: 2   NNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVE 61

Query: 72  LETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHL 131
           ++T L P  LL+   ++E   GR R    RWGPRT DLD+LL+  + ++  +L VPHP +
Sbjct: 62  IKTSLNPFELLELTQQIENELGRTR--EVRWGPRTADLDILLFNRENIETEQLIVPHPRM 119

Query: 132 HVRAFVVVPLAEIAAEL 148
           + R FV+ PLAEI  ++
Sbjct: 120 YERLFVLAPLAEICQQV 136


>gi|98370|pir||F37854 folate biosynthesis protein 2 (sul 3' region)
           - Bacillus subtilis (fragment)
           Length = 162
           
 Score =  113 bits (281), Expect = 8e-25
 Identities = 58/137 (42%), Positives = 84/137 (60%), Gaps = 2/137 (1%)

Query: 12  NVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAA 71
           N +AY+ LG+N+G  E  LR A+A L Q     +   SS+Y T P G +DQA+F+N    
Sbjct: 2   NNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYETDPVGYEDQAQFLNMAVE 61

Query: 72  LETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHL 131
           ++T L P  LL+   ++E   GR R    RWGPRT DLD+LL+  + ++  +L VPHP +
Sbjct: 62  IKTSLNPFELLELTQQIENELGRTR--EVRWGPRTADLDILLFNRENIETEQLIVPHPRM 119

Query: 132 HVRAFVVVPLAEIAAEL 148
           + R FV+ PLAEI  ++
Sbjct: 120 YERLFVLAPLAEICQQV 136


>gi|3970811|emb|CAA10221| (AJ130846)
           7,8-dihydro-6-hydroxymethylpterin -pyrophosphokinase
           [Pseudomonas fluorescens]
           Length = 133
           
 Score =  111 bits (275), Expect = 4e-24
 Identities = 62/127 (48%), Positives = 83/127 (64%), Gaps = 3/127 (2%)

Query: 20  GANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALETGLAPL 79
           G   G  +  LR+AI AL +LP T +   S+ Y++       Q  + NAVAAL++ LAPL
Sbjct: 4   GQQPGCPDQQLRSAIEALAELPGTTVAGVSAFYQSDSL-LPGQPRYTNAVAALDSSLAPL 62

Query: 80  ALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVRAFVVV 139
            LLDAL  +E   GR RL  +RWGPRTLDLD+LL+G+ ++D PRL+VPH  +H+RAFV+ 
Sbjct: 63  ELLDALQAIENDQGRERL--ERWGPRTLDLDILLFGDHLIDEPRLKVPHYQMHLRAFVLY 120

Query: 140 PLAEIAA 146
           PL    A
Sbjct: 121 PLGGTGA 127


>gi|4980526|gb|AAD35135.1|AE001691_9 (AE001691)
           2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
           pyrophosphokinase [Thermotoga maritima]
           Length = 129
           
 Score = 97.5 bits (239), Expect = 6e-20
 Identities = 55/116 (47%), Positives = 73/116 (62%), Gaps = 3/116 (2%)

Query: 49  SSLYRTPPWGRQDQAEFVNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLD 108
           SS+  T P+G +DQ  F+NAV   +T L+P  LL+ LL++E   GRVR    RWGPR +D
Sbjct: 12  SSVIETEPYGYEDQPRFLNAVCIAQTPLSPHELLNTLLQIERNMGRVRTI--RWGPRIID 69

Query: 109 LDLLLYGEQVLDLPRLRVPHPHLHVRAFVVVPLAEIAAELVLPRHG-MVCELLEHI 163
           LD++ Y + VL    L +PHP  H R FV+ PL EIA +L+ P  G  V ELLE +
Sbjct: 70  LDIVFYEDLVLSEEDLIIPHPDAHNRTFVLEPLCEIAPDLIHPVMGKTVRELLEDL 125


>gi|6175071|sp|P22291|SULD_STRPN BIFUNCTIONAL FOLATE SYNTHESIS
           PROTEIN [INCLUDES: DIHYDRONEOPTERIN ALDOLASE (DHNA);
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN
           PYROPHOSPHOKINASE) (HPPK) (6-HYDRO... >gi|2276394
           (U16156) bifunctional aldolase-pyrophosphokinase
           [Streptococcus pneumoniae]
           Length = 270
           
 Score = 91.7 bits (224), Expect = 4e-18
 Identities = 55/137 (40%), Positives = 76/137 (55%), Gaps = 3/137 (2%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALET 74
           A++ LG+N+G  +  L+ AI  L    +  L+  SS+  T PWG  +Q  F N V  +ET
Sbjct: 122 AFIALGSNMGDKQANLKQAIDKLRARGIHILK-ESSVLATEPWGGVEQDSFANQVVEVET 180

Query: 75  GLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVR 134
            L    LL+ LL +E   GRVR     WGPR +DLDLL   +Q+L    L +PHP++  R
Sbjct: 181 WLPAQDLLETLLAIESELGRVREV--HWGPRLIDLDLLFVEDQILYTDDLILPHPYIAER 238

Query: 135 AFVVVPLAEIAAELVLP 151
            FV+  L EIA   + P
Sbjct: 239 LFVLESLQEIAPHFIHP 255


>gi|3738161|emb|CAA21297.1| (AL031856) dihydropteroate synthase
           [Schizosaccharomyces pombe] >gi|3738196|emb|CAA21289.1|
           (AL031854) dihydropteroate synthase [Schizosaccharomyces
           pombe]
           Length = 686
           
 Score = 88.2 bits (215), Expect = 4e-17
 Identities = 53/158 (33%), Positives = 88/158 (55%), Gaps = 3/158 (1%)

Query: 12  NVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAA 71
           N +AY+  G+N+G     ++ A++ L ++   R+   S LY T P   +DQ  F+N V  
Sbjct: 248 NKIAYLSFGSNIGDKFEQIQTALSMLHKIEGIRVLDVSPLYETEPMYYKDQPSFLNGVCK 307

Query: 72  LETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHL 131
           +ET ++P+ LL A   +E   GR++      GPR +DLD++LY + V +   L +PH  L
Sbjct: 308 IETRMSPINLLRACQSIEQEMGRIKT--ILKGPRCIDLDIVLYEDCVYESEVLTIPHLGL 365

Query: 132 HVRAFVVVPLAEIAAELVLP-RHGMVCELLEHIDTLGL 168
             R FV+ PL  ++ +LV P  H  + E L+ + + G+
Sbjct: 366 QEREFVLRPLLALSPDLVHPYTHQPLQEALDKLPSQGI 403


>gi|6016244|sp|O66550|HPPK_AQUAE
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|2982888 (AE000676) folate
           biosynthesis
           7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
           [Aquifex aeolicus]
           Length = 160
           
 Score = 88.2 bits (215), Expect = 4e-17
 Identities = 50/136 (36%), Positives = 76/136 (55%), Gaps = 4/136 (2%)

Query: 16  YVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALETG 75
           Y+GLG+N+G     +  AI  L++     +   S++Y +  WG ++Q  F+N V   +T 
Sbjct: 5   YLGLGSNVGDRISYILKAIEKLEEF--LEIEKISTVYESKAWGFENQGNFLNFVLKAKTS 62

Query: 76  LAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVRA 135
           L P  LL  + +VE   GR      +WGPR +D+D+LLY ++V+    L+VPHP L  R 
Sbjct: 63  LLPQELLLKIKKVEKEVGRKER--FKWGPREIDIDILLYKDEVIRTKLLKVPHPFLEKRD 120

Query: 136 FVVVPLAEIAAELVLP 151
           F V PL EI   ++ P
Sbjct: 121 FFVYPLLEIEPNVIHP 136


>gi|119838|sp|P29251|FAS_PNECA FOLIC ACID SYNTHESIS PROTEIN
           [INCLUDES: DIHYDRONEOPTERIN ALDOLASE (DHNA) (FASA);
           FASB; DIHYDROPTEROATE SYNTHASE (DHPS) (DIHYDROPTEROATE
           PYROPHOSPHORYLASE) (FASC);
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSP... >gi|283062|pir||S28666 multifunctional
           folic acid synthesis protein - Pneumocystis carinii
           >gi|169414 (M86602) folic acid synthesis protein
           [Pneumocystis carinii]
           Length = 740
           
 Score = 86.2 bits (210), Expect = 2e-16
 Identities = 50/146 (34%), Positives = 85/146 (57%), Gaps = 7/146 (4%)

Query: 12  NVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRI--ASSLYRTPPWGRQDQAEFVNAV 69
           N   Y+ LG+NLG     ++  + A++++ +  +++   S LY + P   +DQ  F NAV
Sbjct: 293 NEAVYISLGSNLGNR---IKFILDAIEKMSIKGIKVLKTSMLYESKPMYFKDQPAFYNAV 349

Query: 70  AALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHP 129
             ++T L P  LL  L  +E   GRV++     GPR +DLD++ YG ++++   L +PHP
Sbjct: 350 CKVQTSLHPEQLLFELQLIEKELGRVKVIDK--GPRCIDLDIVFYGRKIINSESLIIPHP 407

Query: 130 HLHVRAFVVVPLAEIAAELVLPRHGM 155
            +  R+FV+ PL +I+ +LV P  G+
Sbjct: 408 RVLERSFVLKPLLDISGDLVHPVTGL 433


>gi|6016249|sp|O83019|HPPK_PORGI
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|3345483|dbj|BAA31956|
           (AB016286)
           7,8-dihydro-6-hydroxymethylpterin-pyrophosphokin ase
           [Porphyromonas gingivalis]
           Length = 147
           
 Score = 76.5 bits (185), Expect = 1e-13
 Identities = 48/134 (35%), Positives = 71/134 (52%), Gaps = 3/134 (2%)

Query: 14  VAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALE 73
           + Y+ LG+NLG     L AA+  L Q  + RL   S  Y T PWG +    F+NAV AL 
Sbjct: 3   IVYLSLGSNLGDRHSLLSAALEML-QTRVGRLLTLSRFYETEPWGFESPHPFLNAVVALR 61

Query: 74  TGLAPLALLDALLEVECFHGRV-RLPGDRWGPRTLDLDLLLYG-EQVLDLPRLRVPHPHL 131
           + L P  +L     +E   GR  +  G  +  R +D+D+LL+     +  P L +PHP +
Sbjct: 62  SELKPQDILHITQAIERELGRTQKSNGGVYHDRPIDIDILLHSVYPKVQSPELELPHPQM 121

Query: 132 HVRAFVVVPLAEIA 145
             R FV +PL+++A
Sbjct: 122 WQRDFVRMPLSDVA 135


>gi|98011|pir||A36704
           2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
           pyrophosphokinase (EC 2.7.6.3) - Streptococcus
           pneumoniae >gi|446074|prf||1911287A dihydroneopterin
           aldolase-hydroxymethyldihydropterin pyrophosphokinas\
           [Streptococcus pneumoniae]
           Length = 270
           
 Score = 74.5 bits (180), Expect = 5e-13
 Identities = 50/137 (36%), Positives = 70/137 (50%), Gaps = 3/137 (2%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALET 74
           A++ LG+N+G  +  L+ AI  L    +  L+ +  L      G      F N V  +ET
Sbjct: 122 AFIALGSNMGDKQANLKQAIDKLRARGIHILKESQCL-SDGALGWSGAGCFANQVVEVET 180

Query: 75  GLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVR 134
            L    LL+ LL +E   GRVR     WGPR +DLDLL   +Q+L    L +PHP++  R
Sbjct: 181 WLPAQDLLETLLAIESELGRVREV--HWGPRLIDLDLLFVEDQILYTDDLILPHPYIAER 238

Query: 135 AFVVVPLAEIAAELVLP 151
            FV+  L EIA   + P
Sbjct: 239 LFVLESLQEIAPHFIHP 255


>gi|4938476|emb|CAB43835.1| (AL078464) dihydropteroate synthase-like
           protein [Arabidopsis thaliana]
           Length = 554
           
 Score = 74.5 bits (180), Expect = 5e-13
 Identities = 48/133 (36%), Positives = 67/133 (50%), Gaps = 3/133 (2%)

Query: 17  VGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALETGL 76
           + LG+N+G      R A+  + +  +   R  S LY T P    DQ  F+NA     T L
Sbjct: 91  IALGSNIGNRMNNFREALRLMKRGGICVTR-HSCLYETAPVHVTDQPRFLNAAVRGVTKL 149

Query: 77  APLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVRAF 136
            P  LL  L  +E   GR    G R+GPR LDLD+L YG+  +   +L +PH  L  R+F
Sbjct: 150 GPHELLSVLKTIERDMGRK--DGIRYGPRPLDLDILFYGKMRISSDKLIIPHERLWERSF 207

Query: 137 VVVPLAEIAAELV 149
           V+ PL ++    V
Sbjct: 208 VLAPLVDLLGSAV 220


>gi|6324073|ref|NP_014143.1|FOL1| dihydroneopterin aldolase,
           dihydro-6-hydroxymethylpterin pyrophosphokinase,
           dihydropteroate synthetase; Fol1p
           >gi|1706767|sp|P53848|FAS_YEAST PROBABLE FOLIC ACID
           SYNTHESIS PROTEIN [INCLUDES: DIHYDRONEOPTERIN ALDOLASE
           (DHNA) (FASA); FASB; DIHYDROPTEROATE SYNTHASE (DHPS)
           (DIHYDROPTEROATE PYROPHOSPHORYLASE) (FASC);
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE...
           >gi|2131946|pir||S63229 hypothetical protein YNL256w -
           yeast (Saccharomyces cerevisiae)
           >gi|1255962|emb|CAA65488| (X96722) ORF N0848
           [Saccharomyces cerevisiae] >gi|1302305|emb|CAA96163|
           (Z71532) ORF YNL256w [Saccharomyces cerevisiae]
           Length = 864
           
 Score = 74.1 bits (179), Expect = 7e-13
 Identities = 48/158 (30%), Positives = 86/158 (54%), Gaps = 9/158 (5%)

Query: 15  AYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALET 74
           A++  G+N+G     ++ A+  L +    +LR  SS++ + P   +DQ  F+N    +ET
Sbjct: 340 AFLAFGSNIGDRFKHIQMALQLLSREKTVKLRNISSIFESEPMYFKDQTPFMNGCVEVET 399

Query: 75  GLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLY----GEQVL-DLPRLRVPHP 129
            L P  LL    ++E +    R+     GPRT+DLD++++    GE ++ + P L +PHP
Sbjct: 400 LLTPSELLKLCKKIE-YEELQRVKHFDNGPRTIDLDIVMFLNSAGEDIIVNEPDLNIPHP 458

Query: 130 HLHVRAFVVVPLAEIAAELVLPRHGMVCE-LLEHIDTL 166
            +  R FV+ PL E+ + + L  H +  E +++H+  L
Sbjct: 459 RMLERTFVLEPLCELISPVHL--HPVTAEPIVDHLKQL 494


>gi|1934972|emb|CAA69903| (Y08611) dihydropterin pyrophosphokinase
           /dihydropteroate synthase [Pisum sativum]
           Length = 515
           
 Score = 72.6 bits (175), Expect = 2e-12
 Identities = 48/143 (33%), Positives = 72/143 (49%), Gaps = 3/143 (2%)

Query: 2   PRWSSRVTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQD 61
           P  S  + + +    + LG+N+G      + A+  + +  +   R AS LY T P    D
Sbjct: 33  PNSSIEIQTQDEEVVIALGSNVGDRLHNFKEALKLMRKSGIHITRHAS-LYETAPAYVTD 91

Query: 62  QAEFVNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDL 121
           Q  F+N+    +T L P  LL AL  +E   GR    G R+GPR +DLD+L YG+  +  
Sbjct: 92  QPRFLNSAVRADTKLGPHELLAALKRIEKDMGRT--DGIRYGPRPIDLDILFYGKFKVRS 149

Query: 122 PRLRVPHPHLHVRAFVVVPLAEI 144
             L VPH  +  R FV+ PL ++
Sbjct: 150 DILTVPHERIWERPFVMAPLMDL 172


>gi|6016248|sp|O06276|HPPK_MYCTU
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|2113970|emb|CAB08938|
           (Z95557) folK [Mycobacterium tuberculosis]
           Length = 188
           
 Score = 69.1 bits (166), Expect = 2e-11
 Identities = 49/134 (36%), Positives = 68/134 (50%), Gaps = 16/134 (11%)

Query: 17  VGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVA-ALETG 75
           + +G+NLG     LR+    L       L  AS +Y   PWG  +Q +F+NAV  A +  
Sbjct: 6   LSVGSNLGDRLARLRSVADGLGDA----LIAASPIYEADPWGGVEQGQFLNAVLIADDPT 61

Query: 76  LAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLL-----YGEQVLDLP----RLRV 126
             P   L    E E   GRVR  G RWGPR LD+DL+        E ++++      L +
Sbjct: 62  CEPREWLRRAQEFERAAGRVR--GQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTL 119

Query: 127 PHPHLHVRAFVVVP 140
           PHP  H+RAFV++P
Sbjct: 120 PHPLAHLRAFVLIP 133


>gi|6016247|sp|O69528|HPPK_MYCLE
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|3097221|emb|CAA18792.1|
           (AL023093) 2-amino-4-hydroxy-6-hydroxymethyl
           dihydropteridine pyrophosphokinase [Mycobacterium
           leprae]
           Length = 191
           
 Score = 67.1 bits (161), Expect = 9e-11
 Identities = 49/145 (33%), Positives = 70/145 (47%), Gaps = 17/145 (11%)

Query: 17  VGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALE-TG 75
           + +G+NLG     L++A+  L    +      S +Y T PWG  +Q  F+NAV   +   
Sbjct: 6   LSIGSNLGDRLAWLQSAVDGLGDAVVA----VSPVYDTVPWGAVEQRSFLNAVVIADGPA 61

Query: 76  LAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYG----------EQVLDLPRLR 125
               A L    E+E   GRVR  G RWG RTLD+DL+             E +     L 
Sbjct: 62  YDTKAWLCRAQELERNAGRVR--GQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLT 119

Query: 126 VPHPHLHVRAFVVVPLAEIAAELVL 150
           +PHP  H+RAFV+VP   + ++  L
Sbjct: 120 LPHPRAHLRAFVLVPWLAVDSDAEL 144


>gi|6730646|gb|AAF27067.1|AC008262_16 (AC008262) F4N2.15
           [Arabidopsis thaliana]
           Length = 459
           
 Score = 66.3 bits (159), Expect = 2e-10
 Identities = 39/96 (40%), Positives = 53/96 (54%), Gaps = 1/96 (1%)

Query: 49  SSLYRTPPWGRQDQAEFVNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLD 108
           S LY T P    DQ  F+NA     T L P  LL+ L ++E   GR    G R+GPR LD
Sbjct: 22  SCLYETEPVHVTDQPRFLNAAIRGVTKLKPHELLNVLKKIEKEMGREE-NGLRYGPRPLD 80

Query: 109 LDLLLYGEQVLDLPRLRVPHPHLHVRAFVVVPLAEI 144
           LD+L YG+  +   +L +PH  +  R FV+ PL ++
Sbjct: 81  LDILFYGKHKIISDKLIIPHERIWERPFVLAPLVDL 116


>gi|6016251|sp|O33726|HPPK_STRPY
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|3242316|emb|CAA04240|
           (AJ000685) hydroxymethylpterin pyrophosphokinase
           [Streptococcus pyogenes]
           Length = 91
           
 Score = 64.8 bits (155), Expect = 5e-10
 Identities = 35/90 (38%), Positives = 48/90 (52%), Gaps = 2/90 (2%)

Query: 14  VAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALE 73
           + Y+ LG N+G     L+ A+ AL  LP TRL   SS+Y T  WG+  QA+F+N    L+
Sbjct: 3   IVYLSLGTNMGDRAAYLQKALEALADLPQTRLLAQSSIYETTAWGKTGQADFLNMACQLD 62

Query: 74  TGLAPLALLDALLEVECFHGRVRLPGDRWG 103
           T L     L     +E   GRVR   ++WG
Sbjct: 63  TQLTAADFLKETQAIEQSLGRVR--HEKWG 90


>gi|6967563|emb|CAB72552.1| (AL139074) putative
           2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
           pyrophosphokinase [Campylobacter jejuni]
           Length = 157
           
 Score = 62.5 bits (149), Expect = 2e-09
 Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 2/143 (1%)

Query: 2   PRWSSRVTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQD 61
           P +S  + S   +A +GLG+N+ P +         +      ++   S +     +G ++
Sbjct: 17  PFFSQNIRSFKYLALIGLGSNIEPEKKRFDMLFRVMMDDKRFKILSTSPMLINEAFGFKE 76

Query: 62  QAEFVNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDL 121
           Q +F NAV  ++T L   ALL  LL  E    R R   +   PRTLDLDLL + ++V   
Sbjct: 77  QKDFTNAVMLIQTNLHARALLKVLLYYEVKFKRKRTFKN--APRTLDLDLLYFSQKVKRD 134

Query: 122 PRLRVPHPHLHVRAFVVVPLAEI 144
               VPH     R  V++PL  I
Sbjct: 135 KWCEVPHKGAKERVSVILPLGMI 157


>gi|4154911 (AE001473) 7,
           8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE
           [Helicobacter pylori J99]
           Length = 163
           
 Score = 60.5 bits (144), Expect = 9e-09
 Identities = 38/125 (30%), Positives = 58/125 (46%)

Query: 17  VGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALETGL 76
           +GLG+NL      L++               +S +Y  PP+G  +Q  F NA   L+T L
Sbjct: 27  LGLGSNLKNPLKILKSCFLYFKNHSKIGKIFSSPIYINPPFGYTNQPNFYNATIILKTSL 86

Query: 77  APLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVRAF 136
                   +  +E   GR R    +  PRTLD+D++ + + +L    L +PHP    R  
Sbjct: 87  GLRHFFALVFYIERRFGRARKRDFKDAPRTLDIDIIAFNQVILRQNDLTLPHPKWSERDS 146

Query: 137 VVVPL 141
           V+VPL
Sbjct: 147 VLVPL 151


>gi|6016245|sp|O25680|HPPK_HELPY
           2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE
           PYROPHOSPHOKINASE
           (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE)
           (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN
           PYROPHOSPHOKINASE) (PPPK) >gi|2314180|gb|AAD08079.1|
           (AE000611) 7,
           8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (folK)
           [Helicobacter pylori 26695]
           Length = 163
           
 Score = 60.1 bits (143), Expect = 1e-08
 Identities = 39/127 (30%), Positives = 64/127 (49%), Gaps = 2/127 (1%)

Query: 17  VGLGANL-GPAEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALETG 75
           +GLG+NL  P ++     +   +   + ++  +S +Y  PP+G   Q  F NA   L+T 
Sbjct: 27  LGLGSNLKNPLKILKNCFLYFKNHSKIGKI-FSSPIYINPPFGYTKQPNFYNATIILKTS 85

Query: 76  LAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDLPRLRVPHPHLHVRA 135
           L+       +  +E   GR R    +  PRTLD+D++ + + +L    L +PHP    R 
Sbjct: 86  LSLRHFFALVFYIERRFGRQRKRDFKDAPRTLDIDIIAFNQVILRQNDLALPHPKWSERD 145

Query: 136 FVVVPLA 142
            V+VPLA
Sbjct: 146 SVLVPLA 152


>gi|3329058|gb|AAC68216.1| (AE001331) Dihydropteroate Synthase
           [Chlamydia trachomatis]
           Length = 450
           
 Score = 54.3 bits (128), Expect = 7e-07
 Identities = 43/172 (25%), Positives = 79/172 (45%), Gaps = 13/172 (7%)

Query: 8   VTSGNVVAYVGLGANLGPAEMTLRAAIAALDQLPLTRLRIA------SSLYRTPPWGRQD 61
           +TS N V  + LG+NLG     +R A A+L +  +  L+ +      + L    P  ++ 
Sbjct: 1   MTSWNFVC-LSLGSNLGNRHEHIRRAYASLKKAGIRNLKSSVILETKALLLEGAP--KEW 57

Query: 62  QAEFVNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQVLDL 121
              + N+V   ET L+P  L++ +  +E   G+      +WGPR +D+D+L YG++    
Sbjct: 58  DLPYFNSVVIGETQLSPDELIEEIKMIESRFGQDA--SLKWGPRPIDIDVLFYGDEAFSY 115

Query: 122 --PRLRVPHPHLHVRAFVVVPLAEIAAELVLPRHGMVCELLEHIDTLGLVPI 171
              +  +PHP +  R F++  +A +         G  C      +   + P+
Sbjct: 116 HSDKCTIPHPKVLERPFLLSMIASLCPYRRFRLEGSSCNGKTFAELAAIYPL 167


>gi|4377065|gb|AAD18896| (AE001657) Dihydropteroate Synthase
           [Chlamydia pneumoniae]
           Length = 450
           
 Score = 48.0 bits (112), Expect = 5e-05
 Identities = 40/139 (28%), Positives = 65/139 (45%), Gaps = 17/139 (12%)

Query: 17  VGLGANLGPAEMTLRAAIAALDQLPLTRLRIASSLYRT---------PPWGRQDQAEFVN 67
           + LG+NLG     L+ A   L +  +  LR +S +  T         P W       + N
Sbjct: 9   LSLGSNLGNRFKNLQIARTLLGEQAVLGLR-SSVILETEALLLPGSPPEW----DLPYFN 63

Query: 68  AVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTLDLDLLLYGEQ--VLDLPRLR 125
           +V   ET L+   LL  + ++E   GR       W PRT+D+D+LLYG++    D   + 
Sbjct: 64  SVLVGETTLSLRELLVTIKQIEKVVGRAE-ESPPWSPRTIDVDILLYGDESFCCDHTEIT 122

Query: 126 VPHPHLHVRAFVVVPLAEI 144
           +P  +L  R F++  +A +
Sbjct: 123 IPLSNLLSRPFLIALIASL 141


>gi|2114408 (U81497) hydroxymethyldihydropterin pyrophosphokinase-
           dihydropteroate synthase [Toxoplasma gondii]
           Length = 664
           
 Score = 41.4 bits (95), Expect = 0.005
 Identities = 29/73 (39%), Positives = 38/73 (51%), Gaps = 13/73 (17%)

Query: 101 RWGPRTLDLDLLLY---GEQVLDLPRLR---------VPHPHLHVRAFVVVPLAEIAAEL 148
           R  PR LDLDLL +   G  V+  P +R         +PHP +  R FV+ PL ++  E 
Sbjct: 154 RGAPRLLDLDLLFFDKNGRSVVIHPDVRPVDKQWPLTLPHPRIITRNFVLFPLCDLDPEY 213

Query: 149 VLPRHGM-VCELL 160
           + P  GM V ELL
Sbjct: 214 IHPVEGMSVKELL 226


>gi|2731631 (U61852) hydroxymethyldihydropterin
           pyrophosphokinase-dihydropteroate synthase [Toxoplasma
           gondii]
           Length = 748
           
 Score = 41.4 bits (95), Expect = 0.005
 Identities = 29/73 (39%), Positives = 38/73 (51%), Gaps = 13/73 (17%)

Query: 101 RWGPRTLDLDLLLY---GEQVLDLPRLR---------VPHPHLHVRAFVVVPLAEIAAEL 148
           R  PR LDLDLL +   G  V+  P +R         +PHP +  R FV+ PL ++  E 
Sbjct: 238 RGAPRLLDLDLLFFDKNGRSVVIHPDVRPVDKQWPLTLPHPRIITRNFVLFPLCDLDPEY 297

Query: 149 VLPRHGM-VCELL 160
           + P  GM V ELL
Sbjct: 298 IHPVEGMSVKELL 310


>gi|3328792|gb|AAC67964.1| (AE001310) Chorismate Synthase [Chlamydia
           trachomatis]
           Length = 357
           
 Score = 32.1 bits (71), Expect = 3.2
 Identities = 17/39 (43%), Positives = 22/39 (55%), Gaps = 1/39 (2%)

Query: 52  YRTPPWGRQDQAEFVNAVAALETGLAPLALLDALLEVEC 90
           YRTP  GR D    + AVA +E  +  L L+D LL+  C
Sbjct: 317 YRTPNQGRHDPCVAIRAVAVVE-AMLDLTLVDLLLQHRC 354


>gi|1125755 (U42833) coded for by C. elegans cDNA yk38h3.5; coded
           for by C. elegans cDNA yk17g1.5; coded for by C. elegans
           cDNA yk3d2.5; coded for by C. elegans cDNA yk5f11.5;
           coded for by C. elegans cDNA yk38h3.3 [Caenorhabditis
           elegans]
           Length = 1650
           
 Score = 31.7 bits (70), Expect = 4.2
 Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 11/93 (11%)

Query: 61  DQAEFVNAVAALETGLAPLALLDALLEVECFHGRVRLPGDRWGPRTL---DLDLLLYGEQ 117
           DQ  + +    L + L P   L ++LE+ C + R RL GD+    T    DLD +++   
Sbjct: 860 DQDAYDDLAIELLSALNPFEQLSSVLEM-CEYVR-RLGGDKPAKSTTTKKDLDTMIFDRT 917

Query: 118 VLDLPRLRVPHPHLHVRAFVVVPLAEIAAELVL 150
              LPR+R      H R  VV  ++ I +  VL
Sbjct: 918 AQTLPRIR------HFRYVVVTLISRIFSNRVL 944


>gi|6742658|gb|AAF15969.2|AF109736_1 (AF109736) O-antigen polymerase
           [Pseudomonas putida]
           Length = 391
           
 Score = 30.5 bits (67), Expect = 9.5
 Identities = 22/78 (28%), Positives = 34/78 (43%), Gaps = 6/78 (7%)

Query: 26  AEMTLRAAIAALDQLPLTRLRIASSLYRTPPWGRQDQAEFVNAVAALETGLAPLALLDAL 85
           A +    A A L Q     L +  ++   P W R   +   + +A L TGLA LA+ D +
Sbjct: 189 AALACLGAFAMLSQSRGAVLALVITVVMAPLWFRDRHSRVFSVLALLATGLAFLAVYDVI 248

Query: 86  LE------VECFHGRVRL 97
            +       E FH  V++
Sbjct: 249 AQRGSSYRPEIFHAVVQM 266


  Database: nr
    Posted date:  Feb 20, 2000 12:20 AM
  Number of letters in database: 140,871,481
  Number of sequences in database:  457,798
  
Lambda     K      H
   0.325    0.142    0.437 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46464039
Number of Sequences: 457798
Number of extensions: 1757039
Number of successful extensions: 4160
Number of sequences better than 10.0: 36
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4085
Number of HSP's gapped (non-prelim): 37
length of query: 172
length of database: 140,871,481
effective HSP length: 49
effective length of query: 123
effective length of database: 118,439,379
effective search space: 14568043617
effective search space used: 14568043617
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.6 bits)
S2: 67 (30.5 bits)