BLASTP 2.0.10 [Aug-26-1999] 

Query= XF-03D03-GL04
         (495 letters)

Database: nr
           457,798 sequences; 140,871,481 total letters

Graphical Overview:

                                                                Score     E
Sequences producing significant alignments:                     (bits)  Value

gi|2177098 (U67894) UDP-MurNAc-Dipeptide: meso-diaminopimelate ...   352    4e-96
gi|127538|sp|P22188|MURE_ECOLI UDP-N-ACETYLMURAMOYLALANYL-D-GLU...   350    1e-95
gi|541194|pir||S40595 UDP-N-acetylmuramoylalanyl-D-glutamate--2...   350    1e-95
gi|1171073|sp|P45060|MURE_HAEIN UDP-N-ACETYLMURAMOYLALANYL-D-GL...   332    3e-90
gi|6525303|gb|AAD29718.2|AF141867_1 (AF141867) probable UDP-N-a...   324    1e-87
gi|417328|sp|Q03523|MURE_BACSU UDP-N-ACETYLMURAMOYLALANYL-D-GLU...   314    1e-84
gi|5689961|emb|CAB51998.1| (AL109663) putative UDP-N-acetylmura...   302    5e-81
gi|2984050 (AE000754) UDP-MurNac-tripeptide synthetase [Aquifex...   284    1e-75
gi|3122401|sp|O06219|MURE_MYCTU UDP-N-ACETYLMURAMOYLALANYL-D-GL...   277    2e-73
gi|3122415|sp|Q55469|MURE_SYNY3 UDP-N-ACETYLMURAMOYLALANYL-D-GL...   277    2e-73
gi|6093448|sp|O69557|MURE_MYCLE UDP-N-ACETYLMURAMOYLALANYL-D-GL...   271    1e-71
gi|5834375|gb|AAD53941.1|AF179611_25 (AF179611) UDP-N-acetylmur...   270    3e-71
gi|4376699|gb|AAD18562| (AE001625) N-Acetylmuramoylalanylglutam...   257    1e-67
gi|3328681|gb|AAC67862.1| (AE001299) UDP-N-acetylmuramoylalanyl...   255    7e-67
gi|2498598|sp|Q59650|MURE_PSEAE UDP-N-ACETYLMURAMOYLALANYL-D-GL...   249    4e-65
gi|6457968|gb|AAF09877.1|AE001890_9 (AE001890) UDP-N-acetylmura...   248    7e-65
gi|4980735|gb|AAD35328.1|AE001707_15 (AE001707) UDP-N-acetylmur...   244    1e-63
gi|6093449|sp|O05954|MURE_RICPR UDP-N-ACETYLMURAMOYLALANYL-D-GL...   239    4e-62
gi|3256223|emb|CAA74740| (Y14370) UDP-N-acetylmuramyl-tripeptid...   225    8e-58
gi|6456164|gb|AAF09152.1|AC011622_9 (AC011622) putative UDP-N-a...   224    1e-57
gi|6093450|sp|O83903|MURE_TREPA UDP-N-ACETYLMURAMOYLALANYL-D-GL...   216    3e-55
gi|6969058|emb|CAB73629.1| (AL139079) UDP-N-acetylmuramoylalany...   199    3e-50
gi|4156007 (AE001561) UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE...   190    2e-47
gi|2314673|gb|AAD08535.1| (AE000648) UDP-MurNac-tripeptide synt...   187    2e-46
gi|3914073|sp|O51219|MURE_BORBU UDP-N-ACETYLMURAMOYLALANYL-D-GL...   180    2e-44
gi|6093446|sp|O85298|MURE_BUCAP UDP-N-ACETYLMURAMOYLALANYL-D-GL...   137    2e-31
gi|6093447|sp|O69290|MURE_CAMJE UDP-N-ACETYLMURAMOYLALANYL-D-GL...   115    7e-25
gi|5689960|emb|CAB51997.1| (AL109663) putative UDP-N-acetylmura...    96    5e-19
gi|2621604 (AE000836) UDP-N-acetylmuramyl tripeptide synthetase...    87    3e-16
gi|3122417|sp|O33804|MURF_STRTO PROBABLE UDP-N-ACETYLMURAMOYLAL...    81    2e-14
gi|5689958|emb|CAB51995.1| (AL109663) putative UDP-N-acetylmura...    76    6e-13
gi|96537|pir||S10691 UDP-N-acetylmuramyl-tripeptide synthetase ...    74    3e-12
gi|2507071|sp|P11880|MURF_ECOLI UDP-N-ACETYLMURAMOYLALANYL-D-GL...    72    9e-12
gi|2177096 (U67893) UDP-MurNAc-Tripeptide:D-Ala-D-Ala-Adding En...    71    3e-11
gi|3122402|sp|O06220|MURF_MYCTU UDP-N-ACETYLMURAMOYLALANYL-D-GL...    70    4e-11
gi|78921|pir||S04846 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6...    70    5e-11
gi|6225735|sp|Q9ZDC2|MURD_RICPR UDP-N-ACETYLMURAMOYLALANINE--D-...    67    4e-10
gi|5834369|gb|AAD53935.1|AF179611_19 (AF179611) UDP-N-acetylmur...    66    7e-10
gi|6460318|gb|AAF12038.1|AE002079_3 (AE002079) UDP-N-acetylmura...    66    7e-10
gi|2621606 (AE000836) UDP-N-acetylmuramyl tripeptide synthetase...    66    9e-10
gi|3122403|sp|O06222|MURD_MYCTU UDP-N-ACETYLMURAMOYLALANINE--D-...    64    3e-09
gi|3393028|emb|CAA06440| (AJ005201) cyanophycin synthetase [Ana...    63    5e-09
gi|6225734|sp|Q9ZDS8|MURC_RICPR UDP-N-ACETYLMURAMATE--ALANINE L...    62    1e-08
gi|2983375 (AE000709) UDP-MURNAC-pentapeptide sythetase [Aquife...    61    2e-08
gi|1171075|sp|P45450|MURF_SYNY3 UDP-N-ACETYLMURAMOYLALANYL-D-GL...    61    2e-08
gi|3024202|sp|P96613|MURF_BACSU UDP-N-ACETYLMURAMOYLALANYL-D-GL...    61    2e-08
gi|3080475|emb|CAA18670.1| (AL022602) udp-n-acetylmuramoylalani...    60    4e-08
gi|3080477|emb|CAA18672.1| (AL022602) udp-n-acetylmuramoylalany...    60    5e-08
gi|1653256|dbj|BAA18171| (D90912) UDP-N-acetylmuramoylalanyl-D-...    60    5e-08
gi|3122410|sp|P73668|MURD_SYNY3 UDP-N-ACETYLMURAMOYLALANINE--D-...    59    7e-08
gi|1652973|dbj|BAA17890| (D90910) hypothetical protein [Synecho...    59    9e-08
gi|4980734|gb|AAD35327.1|AE001707_14 (AE001707) UDP-N-acetylmur...    58    2e-07
gi|5834372|gb|AAD53938.1|AF179611_22 (AF179611) UDP-N-acetylmur...    58    2e-07
gi|6093445|sp|O83873|MURD_TREPA UDP-N-ACETYLMURAMOYLALANINE--D-...    57    4e-07
gi|5834374|gb|AAD53940.1|AF179611_24 (AF179611) UDP-N-acetylmur...    56    6e-07
gi|3122408|sp|O31211|MURC_STAAU UDP-N-ACETYLMURAMATE--ALANINE L...    56    6e-07
gi|6093451|sp|O83401|MURF_TREPA UDP-N-ACETYLMURAMOYLALANYL-D-GL...    55    2e-06
gi|6919927|sp|O67373|MURC_AQUAE UDP-N-ACETYLMURAMATE--ALANINE L...    55    2e-06
gi|6458474|gb|AAF10342.1|AE001931_13 (AE001931) UDP-N-acetylmur...    54    2e-06
gi|3090871 (AF035938) uridine diphosphate N-acetylmuramoyl-L-al...    54    3e-06
gi|1171072|sp|P45063|MURD_HAEIN UDP-N-ACETYLMURAMOYLALANINE--D-...    53    5e-06
gi|4377219|gb|AAD19037| (AE001670) Muramoyl-DAP Ligase [Chlamyd...    53    5e-06
gi|417327|sp|Q03522|MURD_BACSU UDP-N-ACETYLMURAMOYLALANINE--D-G...    52    1e-05
gi|39993|emb|CAA45555| (X64258) UDP-N-acetylmuramoylalanine--D-...    52    1e-05
gi|3122404|sp|O06225|MURC_MYCTU UDP-N-ACETYLMURAMATE--ALANINE L...    51    3e-05
gi|4009480 (AF068902) D-glutamic acid adding enzyme MurD [Strep...    50    3e-05
gi|6458326|gb|AAF10205.1|AE001920_8 (AE001920) UDP-N-acetylmura...    50    5e-05
gi|4377221|gb|AAD19039| (AE001670) Muramoylalanine-Glutamate Li...    49    8e-05
gi|6919932|sp|Q9X827|MURC_STRCO UDP-N-ACETYLMURAMATE--ALANINE L...    48    2e-04
gi|127537|sp|P14900|MURD_ECOLI UDP-N-ACETYLMURAMOYLALANINE--D-G...    47    4e-04
gi|3122405|sp|O07108|MURD_ENTFA UDP-N-ACETYLMURAMOYLALANINE--D-...    46    5e-04
gi|4406514|gb|AAD20011| (AF123319) UDP-N-acetylmuramoylalanyl-D...    46    5e-04
gi|6919931|sp|Q9WY73|MURC_THEMA UDP-N-ACETYLMURAMATE--ALANINE L...    46    7e-04
gi|42046|emb|CAA35611| (X17609) UDP-N-acetylmuramoyl-L-alanine:...    46    7e-04
gi|6225736|sp|O05953|MURF_RICPR PROBABLE UDP-N-ACETYLMURAMOYLAL...    46    9e-04
gi|3329218|gb|AAC68351.1| (AE001348) UDP-N-acetylmuramoylalanyl...    46    9e-04
gi|556014 (L31845) UDP-N-acetyl muramate-alanine ligase [Bacill...    45    0.002
gi|3183540|sp|P40778|MURC_BACSU UDP-N-ACETYLMURAMATE--ALANINE L...    45    0.002
gi|2981818|pdb|1UAG|  Udp-N-Acetylmuramoyl-L-Alanine:d-Glutamat...    45    0.002
gi|6919929|sp|P94335|MURC_CORGL UDP-N-ACETYLMURAMATE--ALANINE L...    44    0.003
gi|3329220|gb|AAC68353.1| (AE001348) UDP-N-acetylmuramoylalanin...    44    0.003
gi|2149895 (U94706) D-glutamic acid adding enzyme [Staphylococc...    43    0.008
gi|3122409|sp|O33595|MURD_STAAU UDP-N-ACETYLMURAMOYLALANINE--D-...    43    0.008
gi|2463563|dbj|BAA22556| (AB007500) MURD [Staphylococcus aureus]      43    0.008
gi|6723459|emb|CAB66325.1| (AJ242646) MurC protein [Brevibacter...    42    0.010
gi|1169724|sp|P43775|FOLC_HAEIN FOLYLPOLYGLUTAMATE SYNTHASE (FO...    42    0.010
gi|4009466 (AF068901) D-Ala-D-Ala adding enzyme [Streptococcus ...    41    0.030
gi|3123061|sp|O26631|Y531_METTH HYPOTHETICAL PROTEIN MTH531 >gi...    39    0.067
gi|3915767|sp|Q51831|MURC_PORGI UDP-N-ACETYLMURAMATE--ALANINE L...    38    0.15
gi|127536|sp|P17952|MURC_ECOLI UDP-N-ACETYLMURAMATE--ALANINE LI...    38    0.20
gi|3914074|sp|O51532|MURD_BORBU UDP-N-ACETYLMURAMOYLALANINE--D-...    38    0.20
gi|2960136|emb|CAA18034.1| (AL022121) hypothetical protein Rv37...    38    0.26
gi|2984290 (AE000771) UDP-N-acetylmuramoylalanine-D-glutamate l...    37    0.34
gi|2213499|emb|CAB09757| (Z97050) adhE [Mycobacterium tuberculo...    37    0.34
gi|4154982 (AE001479) UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE ...    37    0.34
gi|6708108|gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase ...    37    0.44
gi|2313605|gb|AAD07560.1| (AE000564) UDP-N-acetylmuramoylalanin...    36    0.58
gi|703269|gb|AAB38420.1| (L39938) histidine protein kinase [Sin...    35    1.7
gi|3219995|sp|P37773|MPL_ECOLI UDP-N-ACETYLMURAMATE:L-ALANYL-GA...    34    2.9
gi|1405772|emb|CAA98937| (Z74410) nrp [Mycobacterium tuberculosis]    34    2.9
gi|3150111|emb|CAA19164.1| (AL023596) hypothetical protein MLCB...    34    3.8
gi|2498607|sp|Q49617|NADB_MYCLE PROBABLE L-ASPARTATE OXIDASE (Q...    33    6.6
gi|2570172|dbj|BAA22971| (D63452) alchohol dehydrogenase [Arabi...    33    6.6
gi|4155222 (AE001499) D-ALANYL-D-ALANINE-ADDING ENZYME [Helicob...    33    6.6
gi|3798624 (AF082100) FK506 polyketide synthase [Streptomyces s...    32    8.6

>gi|2177098 (U67894) UDP-MurNAc-Dipeptide: meso-diaminopimelate
           ligase [Escherichia coli]
           Length = 495
           
 Score =  352 bits (894), Expect = 4e-96
 Identities = 218/494 (44%), Positives = 274/494 (55%), Gaps = 22/494 (4%)

Query: 10  LLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPA 69
           L P +P A    +  + +DSR    GD FVAV G  A G  +I  A A+G  AI+ E   
Sbjct: 10  LAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKD 69

Query: 70  PQGVSVPDGAIA-VHG--------LRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQ 120
                  DG I  +HG        L  RL A+A RF+  PS  + +VGVTGTNGKT+T Q
Sbjct: 70  ----EATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQ 125

Query: 121 LLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVS 180
           LLAQ    LG  SA  GT+G GL  +V+PT  TT   + +   LA L D+GA   AMEVS
Sbjct: 126 LLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVS 185

Query: 181 SHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPF 240
           SH L Q RV  + +   VFTNL+RDHLDYHGDMEHY AAK  L++      A+IN DD  
Sbjct: 186 SHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEV 245

Query: 241 GLRLLHGLAKGMRRVGVSVCGHTDADVMAQHL---SLNLQGIGFDLVIGAD--HASVRSP 295
           G R    LAK    V VS+  H + +   + L    +N    G  +   +      + S 
Sbjct: 246 GRR---WLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESH 302

Query: 296 LMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHT 355
           LMG FNV NLL     L AL Y L+++    + L+P+ GRM ++    G+P VVVDYAHT
Sbjct: 303 LMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRM-KVFTAPGKPTVVVDYAHT 361

Query: 356 PDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDG 415
           PDAL + L +   H  G+L CVFGCGG+RD+GKR  M  IAE  ADV  VTDDNPR E+ 
Sbjct: 362 PDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEP 421

Query: 416 DGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPF 475
             I+ DILAG       KV   R+ A+  A+  A   DVVL+AGKGHE YQ V   R  +
Sbjct: 422 RAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDY 481

Query: 476 DDTEVARRVLAAMS 489
            D     R+L  +S
Sbjct: 482 SDRVTVARLLGVIS 495


>gi|127538|sp|P22188|MURE_ECOLI
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|96533|pir||S14384
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase (EC 6.3.2.13) - Escherichia
           coli >gi|285768|dbj|BAA01350| (D10483)
           UDP-MurNac-tripeptide synthetase (MurE) [Escherichia
           coli] >gi|581032|emb|CAA38862.1| (X55034)
           UDP-MurNac-tripeptide synthetase (MurE) [Escherichia
           coli] >gi|1786273 (AE000118) meso-diaminopimelate-adding
           enzyme [Escherichia coli]
           Length = 495
           
 Score =  350 bits (889), Expect = 1e-95
 Identities = 217/494 (43%), Positives = 273/494 (54%), Gaps = 22/494 (4%)

Query: 10  LLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPA 69
           L P +P A    +  + +DSR    GD FVAV G  A G  +I  A A+G  AI+ E   
Sbjct: 10  LAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKD 69

Query: 70  PQGVSVPDGAIA-VHG--------LRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQ 120
                  DG I  +HG        L  RL A+A RF+  PS  + +VGVTGTNGKT+T Q
Sbjct: 70  ----EATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQ 125

Query: 121 LLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVS 180
           LLAQ    LG  SA  GT+G GL  +V+PT  TT   + +   LA L D+GA   AMEVS
Sbjct: 126 LLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVS 185

Query: 181 SHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPF 240
           SH L Q RV  + +   VFTNL+RDHLDYHGDMEHY AAK  L++      A+IN DD  
Sbjct: 186 SHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEV 245

Query: 241 GLRLLHGLAKGMRRVGVSVCGHTDADVMAQHL---SLNLQGIGFDLVIGAD--HASVRSP 295
           G R    LAK    V VS+  H + +   + L    +N    G  +   +      + S 
Sbjct: 246 GRR---WLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESH 302

Query: 296 LMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHT 355
           LMG FNV NLL     L AL Y L+++    + L+P+ GRM  +    G+P VVVDYAHT
Sbjct: 303 LMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRM-EVFTAPGKPTVVVDYAHT 361

Query: 356 PDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDG 415
           PDAL + L +   H  G+L CVFGCGG+RD+GKR  M  IAE  ADV  VTDDNPR E+ 
Sbjct: 362 PDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEP 421

Query: 416 DGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPF 475
             I+ DILAG       KV   R+ A+  A+  A   DVVL+AGKGHE YQ V   R  +
Sbjct: 422 RAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDY 481

Query: 476 DDTEVARRVLAAMS 489
            D     R+L  ++
Sbjct: 482 SDRVTVARLLGVIA 495


>gi|541194|pir||S40595
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase (EC 6.3.2.13) murE -
           Escherichia coli
           Length = 495
           
 Score =  350 bits (889), Expect = 1e-95
 Identities = 217/494 (43%), Positives = 273/494 (54%), Gaps = 22/494 (4%)

Query: 10  LLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPA 69
           L P +P A    +  + +DSR    GD FVAV G  A G  +I  A A+G  AI+ E   
Sbjct: 10  LAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKD 69

Query: 70  PQGVSVPDGAIA-VHG--------LRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQ 120
                  DG I  +HG        L  RL A+A RF+  PS  + +VGVTGTNGKT+T Q
Sbjct: 70  ----EATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQ 125

Query: 121 LLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVS 180
           LLAQ    LG  SA  GT+G GL  +V+PT  TT   + +   LA L D+GA   AMEVS
Sbjct: 126 LLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVS 185

Query: 181 SHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPF 240
           SH L Q RV  + +   VFTNL+RDHLDYHGDMEHY AAK  L++      A+IN DD  
Sbjct: 186 SHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEV 245

Query: 241 GLRLLHGLAKGMRRVGVSVCGHTDADVMAQHL---SLNLQGIGFDLVIGAD--HASVRSP 295
           G R    LAK    V VS+  H + +   + L    +N    G  +   +      + S 
Sbjct: 246 GRR---WLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESH 302

Query: 296 LMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHT 355
           LMG FNV NLL     L AL Y L+++    + L+P+ GRM  +    G+P VVVDYAHT
Sbjct: 303 LMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRM-EVFTAPGKPTVVVDYAHT 361

Query: 356 PDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDG 415
           PDAL + L +   H  G+L CVFGCGG+RD+GKR  M  IAE  ADV  VTDDNPR E+ 
Sbjct: 362 PDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEP 421

Query: 416 DGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPF 475
             I+ DILAG       KV   R+ A+  A+  A   DVVL+AGKGHE YQ V   R  +
Sbjct: 422 RAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDY 481

Query: 476 DDTEVARRVLAAMS 489
            D     R+L  ++
Sbjct: 482 SDRVTVARLLGVIA 495


>gi|1171073|sp|P45060|MURE_HAEIN
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|1075415|pir||H64184 UDP-MurNac-tripeptide synthetase
           (murE) homolog - Haemophilus influenzae (strain Rd KW20)
           >gi|1574688 (U32793) UDP-N-acetylmuramyl-tripeptide
           synthetase (murE) [Haemophilus influenzae Rd]
           Length = 488
           
 Score =  332 bits (843), Expect = 3e-90
 Identities = 198/480 (41%), Positives = 265/480 (54%), Gaps = 16/480 (3%)

Query: 13  DIPQAR-DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQ 71
           ++P+ + D+ +  +V+DSR+V+ GD FVA+ G    G  FI+ A   GA A++ E     
Sbjct: 9   NLPELKNDIELHNMVLDSRKVKAGDLFVAIKGHQVDGNQFIDSALHSGASAVVSETELSS 68

Query: 72  GV-------SVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQ 124
                    +VP   +  + L   L ++AD F+  PS  +T+VGVTGTNGKT+  QLLAQ
Sbjct: 69  EHLTVAFIGNVP--VVKYYQLAHHLSSLADVFYDSPSNNLTLVGVTGTNGKTTISQLLAQ 126

Query: 125 AWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHAL 184
               LG R+A  GT+G GL+ Q+V    TT   +++   L+  +  GA   ++EVSSH L
Sbjct: 127 WAELLGHRAAVMGTIGNGLFGQIVEAKNTTGSAVEIQSSLSAFKHAGADFTSIEVSSHGL 186

Query: 185 DQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRL 244
            Q RV+ +H+   +FTNLTRDHLDYH  ME+Y AAK RLF   D Q  VIN DD  G + 
Sbjct: 187 AQHRVEALHFKAAIFTNLTRDHLDYHQSMENYAAAKKRLFTELDTQIKVINADDEIGYQW 246

Query: 245 LHGLAKGM---RRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFN 301
           L  L   +         V  H     +  H       I F+   G  +  + SPL+G FN
Sbjct: 247 LTELPDAIAVSMNADFKVGSHQWMKAINIHYHFKGADITFESSWG--NGVLHSPLIGAFN 304

Query: 302 VDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQ 361
           V NLL V   L +  Y L  + A   +L+ + GRM  +     +P V+VDYAHTPDAL +
Sbjct: 305 VSNLLLVMTTLLSFGYPLENLLATAKSLKGVCGRMEMI-QYPNKPTVIVDYAHTPDALEK 363

Query: 362 VLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVAD 421
            L +   H  G L C+FGCGG+RDRGKR  MA +AE  A+ + VT DNPR E    I  D
Sbjct: 364 ALIAAREHCQGELWCIFGCGGDRDRGKRPLMAQVAEQFAEKIIVTKDNPRTESQSQIETD 423

Query: 422 ILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVA 481
           I+AGF     V +  DR+ AI  AI  A   DV+LIAGKGHE YQ +      F D E+A
Sbjct: 424 IVAGFKNMEKVGIIPDRAQAIQFAIESAVENDVILIAGKGHEHYQIIGSEVVHFSDQEIA 483


>gi|6525303|gb|AAD29718.2|AF141867_1 (AF141867) probable
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase [Vibrio cholerae]
           Length = 495
           
 Score =  324 bits (821), Expect = 1e-87
 Identities = 198/483 (40%), Positives = 272/483 (55%), Gaps = 23/483 (4%)

Query: 15  PQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQ--- 71
           P+   +VI+ L +DSR ++ GD FVA+ G    G  FI+ A A+GA  +L E  A     
Sbjct: 20  PKLAALVITHLELDSRLIKSGDTFVAIQGHAEDGRQFIDKAIAQGANLVLAEADAQHLNG 79

Query: 72  ------GVSVPDGAIAVHGLRARLGAMADRFHG-HPSQAMTMVGVTGTNGKTSTVQLLAQ 124
                 GV V    I +  L   L  +A R +G H +Q   ++GVTGTNGKT+  QL+AQ
Sbjct: 80  WVEYRAGVPV----IYLAELGQHLSELAGRLYGGHHNQ---LIGVTGTNGKTTITQLIAQ 132

Query: 125 AWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHAL 184
               LG ++A  GT G G  + + P   TT   LQ+   L  L + GAQ  A+E SSH L
Sbjct: 133 WLELLGHKAAVMGTTGNGFLNALEPAANTTGNALQIQATLRDLAERGAQYTALETSSHGL 192

Query: 185 DQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRL 244
            QGRV  +H+   VF+NL+RDHLDYHG ME Y AAK  LF+    Q A+INVDD  G + 
Sbjct: 193 VQGRVKKLHFVAGVFSNLSRDHLDYHGTMEAYAAAKFSLFSEHACQNAIINVDDAVGAQW 252

Query: 245 LHGLAKGMRRVGVSVCG--HTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNV 302
           +  L +    +GVS+    +T   + A+ ++    GI  +         + +PL+G FN 
Sbjct: 253 VKQLPQA---IGVSLVTKPNTAQAIWAREVAYAESGITLNFESSWGEGELHAPLIGEFNA 309

Query: 303 DNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQV 362
            NLL     L +L +  S + A    LRP+ GRM  L  ++ +  +VVDYAHTPDAL + 
Sbjct: 310 CNLLLALATLLSLGFEKSALLATAPKLRPVLGRME-LFQREQKAKMVVDYAHTPDALEKA 368

Query: 363 LSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADI 422
           L +L  H  G+L  + GCGG+RDRGKR  MA IAE  AD V +TDDNPR E    IVAD+
Sbjct: 369 LRALRVHCAGQLWAIVGCGGDRDRGKRPMMAAIAEQFADRVILTDDNPRSESPQAIVADM 428

Query: 423 LAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVAR 482
           +AG   P    ++  R  A + A+  A A+D++L+AGKGHE YQ +A     + D E A+
Sbjct: 429 VAGLTYPERAHIEHHRFQAASYALQHAGAQDIILLAGKGHEDYQVLANETIHYSDRETAQ 488

Query: 483 RVL 485
           ++L
Sbjct: 489 QLL 491


>gi|417328|sp|Q03523|MURE_BACSU
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|477729|pir||B47691
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase (EC 6.3.2.13) - Bacillus
           subtilis >gi|40162|emb|CAA78767| (Z15056) murE [Bacillus
           subtilis] >gi|2633889|emb|CAB13391| (Z99111)
           UDP-N-acetylmuramoylananine-D-glutamate-2,6-
           diaminopimelate ligase [Bacillus subtilis]
           Length = 494
           
 Score =  314 bits (796), Expect = 1e-84
 Identities = 189/489 (38%), Positives = 259/489 (52%), Gaps = 17/489 (3%)

Query: 12  PDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQ 71
           P +  ++D  I+ + MDSREV+ G  FV V G+   G  F + A   GA AI+ E     
Sbjct: 14  PSVNDSQDPEITSIEMDSREVKKGSLFVCVKGYTVDGHDFAQKAVENGAAAIVAEREVDV 73

Query: 72  GVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGV 131
            V V    I    LRA L  ++D F+G P++ + ++G+TGTNGKTST  ++ +     G 
Sbjct: 74  NVPV---IIVRQSLRA-LSVLSDAFYGQPTKKLQLIGITGTNGKTSTTHMVDEILKKAGK 129

Query: 132 RSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDG 191
           R+   GT+ + + D+ +P   TTP  + L +   ++ D+      MEVSSHAL  GRV G
Sbjct: 130 RTGLIGTMYMKIGDETLPVKNTTPESVTLQKTFKKMNDKHVDTAIMEVSSHALSLGRVHG 189

Query: 192 VHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFA-------HQDVQAAVINVDDPFGLRL 244
             YD+ VFTNLT+DHLDYH  M+ Y  AK+ LF+       H+  + AV+N DD      
Sbjct: 190 CDYDIAVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFNHEHPKRAVLNADDEASAYF 249

Query: 245 LHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDN 304
               A  +   G+      DADVMA+++S+  QG  FDLV       +   L+G+FNV N
Sbjct: 250 EKVTAAHISTYGIK----NDADVMAKNISITAQGTSFDLVTNKGTKHITMSLVGQFNVYN 305

Query: 305 LLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLS 364
           +LA      A       I   +  L  + GR   +  Q   P V+VDYAHTPD+L  VL 
Sbjct: 306 VLAAVATCIAAGIPFEIITEAVEELHGVRGRFELVNQQQEFP-VIVDYAHTPDSLENVLE 364

Query: 365 SLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILA 424
           +      G+L  V GCGG+RD+ KR +MA IA   AD    T DNPR ED   I+ D+ A
Sbjct: 365 TCRDMTEGKLFVVVGCGGDRDKTKRPKMAKIAVELADEPIFTSDNPRSEDPRAILRDMEA 424

Query: 425 GFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRV 484
           G        +  +R  AI  AI  A   DVVLIAGKGHE YQ++      FDD EVA R 
Sbjct: 425 GVENAYYHSI-ANREQAIFFAIANAKKGDVVLIAGKGHETYQQIGNETFDFDDAEVAARA 483

Query: 485 LAAMSAQET 493
           +  ++  +T
Sbjct: 484 IVELNKNKT 492


>gi|5689961|emb|CAB51998.1| (AL109663) putative
           UDP-N-acetylmuramoylalanyl-D-glutamate-2,
           6-diaminopimelate ligase [Streptomyces coelicolor A3(2)]
           Length = 506
           
 Score =  302 bits (765), Expect = 5e-81
 Identities = 194/496 (39%), Positives = 270/496 (54%), Gaps = 26/496 (5%)

Query: 6   PLAQLLPDIPQAR---DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVA 62
           PLA+L   +  A       I+G+  DSR V+PGD + A+ G   HG  F+  A   GA A
Sbjct: 16  PLAELADQLGVAAPDGSAEITGITHDSRAVRPGDLYAALPGARLHGADFVTQAAGLGAAA 75

Query: 63  ILFEPP-APQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQL 121
           +L +P  A +  +    A+ V   RAR+G +A   +GHP + +  +G+TGT+GKT+T  L
Sbjct: 76  VLTDPAGAERAAAAGLPALVVDDPRARMGELAATIYGHPGRDLLQIGITGTSGKTTTAYL 135

Query: 122 LAQAWHCLGVRSATC----GTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAM 177
           +       G+R+A      GT+ + + D+ + +  TTP    L    A +R+ G +AVAM
Sbjct: 136 VEG-----GLRTAKSTGLIGTVEMRIGDERIKSERTTPEATDLQALFAVMRERGTEAVAM 190

Query: 178 EVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVD 237
           EVSSHAL  GRVD   +D+ VFTNL+ +H+++H  ME Y  AKA+LF  +  +  V+NVD
Sbjct: 191 EVSSHALVLGRVDACVFDIAVFTNLSPEHMEFHSGMEDYFQAKAQLFTPKRSRLGVVNVD 250

Query: 238 DPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIG--ADHASVRSP 295
           D +G RL       +  V  S  GH DAD  A  + +      F  V+G   +  + +SP
Sbjct: 251 DEYGRRLAKEATVPV--VTYSAEGHPDADWRADEVEVGPLDSTF-TVLGPKGERIAAKSP 307

Query: 296 LMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQP-VVVVDYAH 354
           L G FNV N LA    L A        A  ++ +  + GR+ R+   +GQP   VVDYAH
Sbjct: 308 LAGPFNVANTLAAIVALAAAGLDPQSAADGVAAVPGVPGRLERV--DEGQPFFAVVDYAH 365

Query: 355 TPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGED 414
             DA+  VL +L     G+L  V GCGG+RD  KR  M       AD   +T DNPR ED
Sbjct: 366 KTDAVESVLRALRKVTEGKLHAVLGCGGDRDTTKREPMGAAVARFADTAVLTSDNPRSED 425

Query: 415 GDGIVADILAGFA-----RPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVA 469
              I+A +L G A         V+V  DR+AAIAAA+  A   D VL+AGKGHE+ Q++A
Sbjct: 426 PLAILATMLQGAASVPAHERGEVQVFEDRAAAIAAAVARAEPGDTVLVAGKGHEQGQDIA 485

Query: 470 GVRHPFDDTEVARRVL 485
           GV  PFDD +V R  +
Sbjct: 486 GVVRPFDDRQVLREAI 501


>gi|2984050 (AE000754) UDP-MurNac-tripeptide synthetase [Aquifex
           aeolicus]
           Length = 482
           
 Score =  284 bits (719), Expect = 1e-75
 Identities = 173/469 (36%), Positives = 254/469 (53%), Gaps = 23/469 (4%)

Query: 22  ISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAIA 81
           + G+ ++S+EV+ G  F A+ G    G  FI +A  RGA A++ E P    V V    I 
Sbjct: 23  VKGITLNSKEVKKGYLFFAIKGTRFDGHNFIREAEERGAYAVVVERPVSSKVPV----II 78

Query: 82  VHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGV 141
           V   R  LG  A  F G PS+ + ++G+TGTNGKT+T  L+ +     G ++   GT+  
Sbjct: 79  VEDTRKALGKSAHEFFGKPSERLNVIGITGTNGKTTTTHLIEKILLEAGEKTGLIGTIYY 138

Query: 142 GLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTN 201
            L ++++ +G TTP  +  H+ L +  + GA+ V  E+SSHALDQ RV    ++ V+FTN
Sbjct: 139 RLGEKILGSGRTTPDQITWHRTLKEFYELGAKNVVAEISSHALDQYRVYPTRFEAVLFTN 198

Query: 202 LTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRLL---HGLAKGMRRVGVS 258
           L++DHLDYH  ME Y A+KA+LF   + +  +IN DD +G RLL   HG      + G  
Sbjct: 199 LSQDHLDYHKTMEDYFASKAKLFTEYESKVKIINADDTYGKRLLKITHGEIITYGKKG-- 256

Query: 259 VCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYA 318
                  D+   +   + +G    +          + L+G F   NL   A + YAL   
Sbjct: 257 -------DLKILNFRTDFRGSALRIAFKGKEYEFSTNLIGDFQAYNL--SAAIAYALWKG 307

Query: 319 LSE--IAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLIC 376
           +    I   L  +  + GR   +     +  V++DYAHTPDA+  VL +      G+LI 
Sbjct: 308 IEPDLIQRALKCVN-VPGRFEVV--HSDKFTVIIDYAHTPDAVENVLRTARKLSKGKLIS 364

Query: 377 VFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQR 436
           VFG GG RDR KR  M   AE  +D++ +T DNPR E+ + I+ DIL G +  + V ++ 
Sbjct: 365 VFGAGGNRDREKRPLMGKAAEKYSDLIILTSDNPRDEEPEKIIEDILDGISEKDKVIIEA 424

Query: 437 DRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVL 485
           DR  AI  AI +A   D+V I GKGHE YQE+ GV++PF D +V + +L
Sbjct: 425 DRRKAIKKAIDMAKEGDMVAILGKGHEDYQEIKGVKYPFSDAQVVKEIL 473


>gi|3122401|sp|O06219|MURE_MYCTU
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|2104320|emb|CAB08669| (Z95388) murE [Mycobacterium
           tuberculosis]
           Length = 535
           
 Score =  277 bits (701), Expect = 2e-73
 Identities = 187/482 (38%), Positives = 252/482 (51%), Gaps = 21/482 (4%)

Query: 19  DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDG 78
           D  ++G+ + +++V PGD F A+ G   HG   + DA ARGAVA+L +P    GV+   G
Sbjct: 59  DRTVTGVTLRAQDVSPGDLFAALTGSTTHGARHVGDAIARGAVAVLTDPA---GVAEIAG 115

Query: 79  AIAVHGL-----RARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRS 133
             AV  L     R  LG +A   +GHPS+ +T++G+TGT+GKT+T  L+       G  +
Sbjct: 116 RAAVPVLVHPAPRGVLGGLAATVYGHPSERLTVIGITGTSGKTTTTYLVEAGLRAAGRVA 175

Query: 134 ATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVH 193
              GT+G+ +    +P+  TTP    L   LA + + G   V MEVSSHAL  GRVDG  
Sbjct: 176 GLIGTIGIRVGGADLPSALTTPEAPTLQAMLAAMVERGVDTVVMEVSSHALALGRVDGTR 235

Query: 194 YDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQD---VQAAVINVDDPFGLRLLHGLAK 250
           + V  FTNL+RDHLD+H  M  Y  AKA LF        + AV+ +DD  G  +    A 
Sbjct: 236 FAVGAFTNLSRDHLDFHPSMADYFEAKASLFDPDSALRARTAVVCIDDDAGRAMAARAAD 295

Query: 251 GMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAG 310
            +         H  A  +A   +   Q    D      H  +R P  GR+NV N L    
Sbjct: 296 AITVSAADRPAHWRATDVAPTDAGGQQFTAIDPAGVGHHIGIRLP--GRYNVANCLVALA 353

Query: 311 VLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHV 370
           +L  +  +  +    L  +R + GR+ ++    G  + +VDYAH P+AL  VL++L +H 
Sbjct: 354 ILDTVGVSPEQAVPGLREIR-VPGRLEQIDRGQGF-LALVDYAHKPEALRSVLTTL-AHP 410

Query: 371 CGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFAR-- 428
             RL  VFG GG+RD GKR+ M  IA   AD+V VTDDNPR ED   I  +ILAG A   
Sbjct: 411 DRRLAVVFGAGGDRDPGKRAPMGRIAAQLADLVVVTDDNPRDEDPTAIRREILAGAAEVG 470

Query: 429 --PNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVLA 486
               VV++  DR  AI  A+  A   DVVLIAGKGHE  Q   G   PFDD       L 
Sbjct: 471 GDAQVVEI-ADRRDAIRHAVAWARPGDVVLIAGKGHETGQRGGGRVRPFDDRVELAAALE 529

Query: 487 AM 488
           A+
Sbjct: 530 AL 531


>gi|3122415|sp|Q55469|MURE_SYNY3
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|1001328|dbj|BAA10815| (D64006) UDP-MurNac-tripeptide
           synthetase [Synechocystis sp.]
           Length = 505
           
 Score =  277 bits (701), Expect = 2e-73
 Identities = 188/471 (39%), Positives = 246/471 (51%), Gaps = 10/471 (2%)

Query: 21  VISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDG-- 78
           +++GL  +S    PG  F+ + G    G  F   A   GA+A +    A Q     +G  
Sbjct: 34  IVTGLSTNSHACPPGTLFIGMPGTRVDGGEFWSGALEAGAIAAVVSEKALQKFPPQNGEC 93

Query: 79  AIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGT 138
            IAV  L      +A  F+ HP+Q + +VGVTGTNGKT+T  L+    +     SA  GT
Sbjct: 94  VIAVPDLVPVCAGLAAAFYQHPAQTLQLVGVTGTNGKTTTSHLIEYFLNQQQRSSALLGT 153

Query: 139 LGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVV 198
           L             TTP    L + LA+    G Q   MEVSSHAL QGRV    +   V
Sbjct: 154 LYTRWPGYQKTATHTTPFATDLQKQLAEALQAGNQYAVMEVSSHALAQGRVLQCGFACAV 213

Query: 199 FTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQA-AVINVDDPFGLRLLHGLAKGMRRVGV 257
           FTNLT+DHLD+HG ME+Y AAKA LF    +Q  AVIN DDP+G RL+  L   + +V  
Sbjct: 214 FTNLTQDHLDFHGTMENYFAAKALLFKESYLQGRAVINQDDPYGQRLIDRLP--LDQVYT 271

Query: 258 SVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNY 317
                + AD   + L     G+    V         SPL+G+FN+ N+LA   +   L+ 
Sbjct: 272 YSVNDSTADFYTKDLDYQPTGVKGTFVTPQGEFPFLSPLVGQFNLANVLAA--IASGLHL 329

Query: 318 ALSEIAAVLSTLR--PIHGRMNRLGGQDGQPV-VVVDYAHTPDALGQVLSSLSSHVCGRL 374
            L   A V   L    + GRM ++  +  Q + V+VDYAHTPD+L   L +    + GRL
Sbjct: 330 GLDPAAMVKDLLDFPGVPGRMEQVQIRPDQDISVMVDYAHTPDSLENALKAARPFIPGRL 389

Query: 375 ICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKV 434
           IC+FGCGG+RDR KR  M  IA   AD+  VT DNPR ED + I+AD++ G +      +
Sbjct: 390 ICIFGCGGDRDRTKRPLMGNIAAQLADLAVVTSDNPRTEDPEQILADVVQGISLDIEPWI 449

Query: 435 QRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVL 485
             DR+ AI  AI  A   D VLIAGKGHE YQ +   +  FDD E AR  L
Sbjct: 450 IGDRATAIHKAIREAKPGDGVLIAGKGHEDYQILGTEKIHFDDREQAREAL 500


>gi|6093448|sp|O69557|MURE_MYCLE
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|3080478|emb|CAA18673.1| (AL022602)
           udp-n-acetylmuramoylalanyl-d-glutamate
           --2,6-diaminopimelate ligase [Mycobacterium leprae]
           Length = 530
           
 Score =  271 bits (685), Expect = 1e-71
 Identities = 196/504 (38%), Positives = 260/504 (50%), Gaps = 42/504 (8%)

Query: 8   AQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEP 67
           A  +PDIP      ++G+ + ++EV  GD F A+AG   HG  +   A  RGAVA+L + 
Sbjct: 39  AATVPDIP------VTGVTLRAQEVLSGDLFAALAGASTHGARYAGVALERGAVAVLTDV 92

Query: 68  PA-----PQGVSVPDGAIAVHGL-RARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQL 121
                   Q  SVP   I +H   R+ LG +A   +GHPS  MT+VG+TGT+GKT+T  +
Sbjct: 93  AGVAELTAQASSVP---ILIHPEPRSVLGGLAAAAYGHPSNRMTVVGITGTSGKTTTTYM 149

Query: 122 LAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSS 181
           +       G      GT+G+ +    +P+  TTP    L   LA + + G + V MEVSS
Sbjct: 150 VEAGLRAGGRVVGLVGTIGIRIDGADIPSFLTTPEAPALQAMLAAMVERGVETVVMEVSS 209

Query: 182 HALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDV---QAAVINVDD 238
           HAL  GRV+G  + V  FTNL+RDHLD+H DME Y  AKA LF    +   +  V+ +DD
Sbjct: 210 HALSLGRVEGTQFAVAGFTNLSRDHLDFHPDMEEYFEAKAVLFDPHSLLRARTVVVCIDD 269

Query: 239 PFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRS---- 294
             G       A+    + VS  G        +   +   G+G       D A V+     
Sbjct: 270 DAGRAT---AARAGDAITVSALGQ---PASWRATDIRSPGVGAQEFTAVDPAGVQHRVGI 323

Query: 295 PLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLG-GQDGQPVVVVDYA 353
            L GR+NV N L    +L  +  +  + +     +R I GR+ R+  GQD   + +VDYA
Sbjct: 324 RLPGRYNVANCLVALAILDVVGVSPEQASLGFRDIR-IPGRLERIDCGQDF--LALVDYA 380

Query: 354 HTPDALGQVLSSL--SSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPR 411
           H P AL  VL++L    H   RL  VFG GGERD GKR+ M  IA   AD+V VTDDNPR
Sbjct: 381 HKPGALHSVLTALLQPDH---RLAVVFGAGGERDPGKRAPMGEIAAELADLVVVTDDNPR 437

Query: 412 GEDGDGIVADILAGF----ARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQE 467
           GED   I  DIL G         VV++  DR AAI  A+  A  +DVVL+AGKGHE  Q 
Sbjct: 438 GEDPAAIRRDILTGTVAAGGAAQVVEI-GDRRAAIQYAVAWAGPDDVVLVAGKGHETGQR 496

Query: 468 VAGVRHPFDDTEVARRVLAAMSAQ 491
            A    PFDD     R L    A+
Sbjct: 497 GAAETCPFDDRVELARALQVRDAR 520


>gi|5834375|gb|AAD53941.1|AF179611_25 (AF179611)
           UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-
           diaminopimelate ligase [Zymomonas mobilis]
           Length = 485
           
 Score =  270 bits (682), Expect = 3e-71
 Identities = 183/485 (37%), Positives = 245/485 (49%), Gaps = 33/485 (6%)

Query: 15  PQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVS 74
           P+ +D  + G  +DSR+V  G  F A  G   +G  FIE A A GAVAI+  P       
Sbjct: 19  PKEKDYPVLGFAVDSRKVAKGFVFGAFPGAKVNGEDFIEKAIAAGAVAIVARPEVKI--- 75

Query: 75  VPDGAIAVHGLRARLG--AMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVR 132
             +GA+ +     RL    MA RF+        M  VTGTNGKTS  +L  Q W   G +
Sbjct: 76  --EGAVHLVAENPRLAFAEMAARFYA--PFPPVMAAVTGTNGKTSVAELCRQLWTITGHK 131

Query: 133 SATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGV 192
           +A+ GTLGV         G TTP V+    C + L       V  E SSH LDQ R DG 
Sbjct: 132 AASIGTLGVITAKNSYSLGMTTPDVVTFLSCCSDLARADISHVIFEASSHGLDQYRSDGA 191

Query: 193 HYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQ--AAVINVDDPFGLRLL-HGLA 249
                 FT+ +RDHLDYHG ME Y AAK RLF  +      AVI  DDP    ++ H   
Sbjct: 192 KVIAGAFTSFSRDHLDYHGTMERYLAAKLRLFDERIAPDGTAVIWADDPAATTVIAHVQK 251

Query: 250 KGMRRVGVSVCG-----HTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDN 304
           +G++ + +         + +AD   Q ++L+++G  +          +R PL+G + + N
Sbjct: 252 RGLKLIDIWKAEAIRLVNREADSQGQMITLSIKGESY---------KIRLPLIGGYQLSN 302

Query: 305 LLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLS 364
            L  AG++ A    + +  A L+ L+P+ GR+ R         V VDYAHTPD L   + 
Sbjct: 303 GLVRAGLVLATGGDIKQTMAALTLLKPVRGRLERATQSQNGAEVYVDYAHTPDGLRAAIE 362

Query: 365 SLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILA 424
           +L  H  G L  VFG GG+RD+GKR +M  IA + AD V VTDDNPRGED   I  ++L 
Sbjct: 363 ALRPHTEGLLWVVFGAGGDRDKGKRPEMGKIAANLADHVIVTDDNPRGEDAATIRKEVLV 422

Query: 425 GFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRH----PFDDTEV 480
           G      +     R  AI +AI  A   D+VLIAGKGHE+ Q +         PFDD  V
Sbjct: 423 GAPLAEEI---GGRKEAIFSAIKRAEKGDIVLIAGKGHEQGQIIGRGETMRVLPFDDVTV 479

Query: 481 ARRVL 485
           A+  +
Sbjct: 480 AKEAV 484


>gi|4376699|gb|AAD18562| (AE001625) N-Acetylmuramoylalanylglutamyl
           DAP Ligase [Chlamydia pneumoniae]
           Length = 483
           
 Score =  257 bits (650), Expect = 1e-67
 Identities = 181/476 (38%), Positives = 242/476 (50%), Gaps = 15/476 (3%)

Query: 16  QARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSV 75
           + R + +  L  DSR V  GD F+A  G    G  F  DA A GA+AI      P    V
Sbjct: 17  KVRPLEVRNLTRDSRCVSVGDIFIAHKGQRYDGNDFAVDALANGAIAIASSLYNPFLSVV 76

Query: 76  PDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSAT 135
                 +  L A L A   +++ +PS  +  +GVTGTNGKT+   L+          S  
Sbjct: 77  QIITPNLEELEAELSA---KYYEYPSSKLHTIGVTGTNGKTTVTCLIKALLDSYQKPSGL 133

Query: 136 CGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYD 195
            GT+   L + V+  GFTTP    L + LA +  +   AV MEVSS  L  GRV   ++D
Sbjct: 134 LGTIEHILGEGVIKDGFTTPTPALLQKYLATMVRQNRDAVVMEVSSIGLASGRVAYTNFD 193

Query: 196 VVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQA-AVINVDDPFGLRLLHGLAKGMRR 254
             V TN+T DHLD+HG  E Y AAKA+LF+        VIN D P+  + +      +  
Sbjct: 194 TAVLTNITLDHLDFHGTFETYVAAKAKLFSLVPPSGMVVINTDSPYASQCIESAKAPVIT 253

Query: 255 VGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYA 314
            G+     + AD  A  + L+  G  + LV G    +  S  +G++NV NLLA    ++A
Sbjct: 254 YGI----ESAADYRATDIQLSSSGTKYTLVYGDQKIACSSSFIGKYNVYNLLAAISTVHA 309

Query: 315 -LNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHV--C 371
            L   L ++   +   +P  GR++ +    G   V +DYAHTPDAL  VL+ L   +   
Sbjct: 310 SLRCDLEDLLEKIGLCQPPPGRLDPV--LMGPCPVYIDYAHTPDALDNVLTGLHELLPEG 367

Query: 372 GRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNV 431
           GRLI VFGCGG+RDR KR  MA + E     V VT DNPR E  + IV +I  GF   N 
Sbjct: 368 GRLIVVFGCGGDRDRSKRKLMAQVVERYGFAV-VTSDNPRSEPPEDIVNEICDGFYSKNY 426

Query: 432 VKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVLAA 487
             ++ DR  AI  A+ IAS  D+VLIAGKGHE YQ        FDD +    VLA+
Sbjct: 427 F-IEIDRKQAITYALSIASDRDIVLIAGKGHEAYQIFKHQTVAFDDKQTVCEVLAS 481


>gi|3328681|gb|AAC67862.1| (AE001299)
           UDP-N-acetylmuramoylalanylglutamyl DAP Ligase [Chlamydia
           trachomatis]
           Length = 483
           
 Score =  255 bits (644), Expect = 7e-67
 Identities = 182/496 (36%), Positives = 258/496 (51%), Gaps = 26/496 (5%)

Query: 5   MPLAQLLPDIP-----QARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARG 59
           M L QLL +IP     +   + +  L  DSR V  GD F+A  G   +G  +   A A G
Sbjct: 1   MHLDQLLQNIPAKIYGKVESIPVRNLTRDSRCVGVGDIFIARQGQFCNGNDYSSQAVANG 60

Query: 60  AVAIL---FEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKT 116
           A+A+L   + P       + +  IA+        ++A RF+ +PS+ + ++G+TGTNGKT
Sbjct: 61  AIAVLSSLYNPFLSVVQIIAEDPIALEA------SLAARFYNNPSRHLDVIGITGTNGKT 114

Query: 117 STVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVA 176
           +   L+ +     G R+   GT+   L +  +   FTTP  + L +  A++  +   A  
Sbjct: 115 TVSCLVRELMERSGRRTGLIGTIEHILGENRIIDSFTTPDAILLQKYFAEMVKQNLSAAV 174

Query: 177 MEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH-QDVQAAVIN 235
           MEVSS  +  GRV    +   V TN+T DHLD+HG +E Y AAK + FA   +   AV+N
Sbjct: 175 MEVSSIGMALGRVRETEFLAGVLTNITSDHLDFHGSLEEYIAAKKQFFASLPEKGIAVVN 234

Query: 236 VDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSP 295
           +D  +    L+    G +   VS   H +AD  A  L L   G  +D+          + 
Sbjct: 235 LDCEYAPSFLN----GSQARAVSYAIHQEADYRADRLKLYSSGSSYDIWYQGQVFPCETS 290

Query: 296 LMGRFNVDNLLAVAGVLYA-LNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAH 354
           L+G  NV N+LA   V++  L    +++   +  L    GR++ +    G   V +DYAH
Sbjct: 291 LIGEHNVYNVLASLAVVHQFLGRDFADLVRDVRFLSAPKGRLDPI--LLGPFPVYIDYAH 348

Query: 355 TPDALGQVLSSLSSHV--CGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRG 412
           TPDAL  V   L   +   GRLI VFGCGG+RDR KR  MA ++E +    FVT DNPR 
Sbjct: 349 TPDALDNVCRILLQLLPKDGRLIIVFGCGGDRDRVKRPLMAKVSE-HYGFSFVTSDNPRT 407

Query: 413 EDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVR 472
           ED D I+ADI  GF+  + V V+ DR  AI  AI +AS +D+VL+AGKGHE YQ      
Sbjct: 408 EDPDQIIADICKGFSTDHYV-VESDRKLAIEKAISMASDKDIVLVAGKGHEGYQIFKHQT 466

Query: 473 HPFDDTEVARRVLAAM 488
             FDD EV    LAA+
Sbjct: 467 IVFDDREVVCEALAAL 482


>gi|2498598|sp|Q59650|MURE_PSEAE
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|1084033|pir||S54873
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase (EC 6.3.2.13) - Pseudomonas
           aeruginosa (fragment) >gi|840843|emb|CAA58873| (X84053)
           UDP-N-acetylmuramoylalanyl-D-glutamate--
           2,6-diaminopimelate ligase [Pseudomonas aeruginosa]
           Length = 325
           
 Score =  249 bits (629), Expect = 4e-65
 Identities = 149/327 (45%), Positives = 190/327 (57%), Gaps = 5/327 (1%)

Query: 5   MPLAQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAIL 64
           M L+QL P     RD++I  L +DS  V+P D F+ V G    G   I DA  +GA A+ 
Sbjct: 3   MSLSQLFPQAE--RDLLIRELTLDSHGVRPVDLFLTVPGGHQDGRAHIADALTKGATAVA 60

Query: 65  FEPPAPQGVSVPDGA-IAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLA 123
           +E      +   D   IAV GL A+L A+A RF+G PS+ + ++GVTGTNGKTS  QL+A
Sbjct: 61  YEAEGAGELPPSDAPLIAVKGLAAQLSAVAGRFYGEPSRGLDLIGVTGTNGKTSVSQLVA 120

Query: 124 QAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHA 183
           QA   LG R    GTLG G Y  +     TTP  L +   LA L+  GA+AVAMEVSSH 
Sbjct: 121 QALDLLGERCGIVGTLGTGFYGALESGRHTTPDPLAVQATLATLKQAGARAVAMEVSSHG 180

Query: 184 LDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLR 243
           LDQGRV  + +D+ VFTNL+RDHLDYHG ME Y AAKA+LFA  D++  VIN+DD FG R
Sbjct: 181 LDQGRVAALGFDIAVFTNLSRDHLDYHGSMEAYAAAKAKLFAWPDLRCRVINLDDDFGRR 240

Query: 244 LLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVD 303
           L  G  +    +  S+   + A +  +       GI   LV       +RSPL+GRFN+ 
Sbjct: 241 LA-GEEQDSELITYSLT-DSSAFLYCREARFGDAGIEAALVTPHGEGLLRSPLLGRFNLS 298

Query: 304 NLLAVAGVLYALNYALSEIAAVLSTLR 330
           NLLA  G L  L Y L +I   L  L+
Sbjct: 299 NLLAAVGALLGLGYPLGDILRTLPQLQ 325


>gi|6457968|gb|AAF09877.1|AE001890_9 (AE001890)
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase [Deinococcus radiodurans]
           Length = 490
           
 Score =  248 bits (627), Expect = 7e-65
 Identities = 175/482 (36%), Positives = 250/482 (51%), Gaps = 15/482 (3%)

Query: 12  PDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQ 71
           P+     D  ++G+  ++  VQPG AFVA+ G    G  F+E A A GAVA+L E  A  
Sbjct: 15  PETDPQTDTEVTGVTHNAAWVQPGSAFVAIRGAKFDGHSFMEQAQAAGAVAVLGEGLA-D 73

Query: 72  GVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGV 131
           G + P   + V   RA L   A    GHPS+ + +VGVTGT+GKT+T  L        G+
Sbjct: 74  GQTSPLPYLTVPNARAALADAAAALAGHPSRELKVVGVTGTDGKTTTSWLTRHLLRSAGL 133

Query: 132 RSATCGTLGVGLYDQVV---PTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGR 188
            +    T+G  L D  +   P  FTTP   Q+   L ++   GAQA  +E SSHAL   R
Sbjct: 134 ATGLLSTVGYELPDGELRHFPAHFTTPEAPQVQDTLREMVAAGAQATVLEASSHALSLDR 193

Query: 189 VDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRLLHGL 248
           V GV +DV V+T+L+ +HLD+HG +++Y A K +L   +  + AV+NVDDP+  + L G+
Sbjct: 194 VRGVDWDVAVWTHLSSEHLDFHGTLDNYFADKRKLV--ERARFAVLNVDDPWTAQ-LRGI 250

Query: 249 AKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAV 308
           A G          +  AD  AQ +     G+ F +V  A       P++GRFNV N LA 
Sbjct: 251 APGETTYSAE---NQHADWRAQDIEERHSGLHFRVVSPAGDFQAELPMIGRFNVANALAG 307

Query: 309 AGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSS 368
               + L     ++ A L++ R + GRM  + G    P V+VD+AHTP +L + L +L +
Sbjct: 308 MAAAHHLGATALQLQAGLASFRGVPGRMELVPGGATSPRVIVDFAHTPPSLEKALGTLRA 367

Query: 369 HVCGRLICVFG-CGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGF- 426
              G L  V G  GG RD  KR+ +  +A   AD   +T+++ R      I+ ++  G  
Sbjct: 368 TTAGHLWVVIGSAGGPRDPYKRAPLGEVATRLADHAILTEEDCRDTPLQDILNEMERGAR 427

Query: 427 --ARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRV 484
              R N V +  DR  AI  A+  A   D VL+AGKG E   E A    P+++   AR V
Sbjct: 428 EEGRSNFVSI-GDRREAIRYAVTHAQPGDTVLLAGKGPEDTLERATETLPWNEVAEARAV 486

Query: 485 LA 486
           LA
Sbjct: 487 LA 488


>gi|4980735|gb|AAD35328.1|AE001707_15 (AE001707)
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase [Thermotoga maritima]
           Length = 490
           
 Score =  244 bits (617), Expect = 1e-63
 Identities = 171/491 (34%), Positives = 253/491 (50%), Gaps = 33/491 (6%)

Query: 7   LAQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAG--FGAHGLCFIEDACARGAVAIL 64
           L  L+ ++    D+ I+G+   S +V+ GD F+   G  F +H +  I +   +GAVA++
Sbjct: 10  LKDLILEVRAPYDLEITGVSNHSSKVKKGDLFICRRGEKFDSHEI--IPEVMEKGAVAVV 67

Query: 65  FEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQ 124
            E    + + +    I V   R     +A  F   P + +   GVTGTNGKT+T  ++  
Sbjct: 68  VE----REIDLDFPYIQVFDSRYFEAKVASLFFEDPWKDVLTFGVTGTNGKTTTTMMIYH 123

Query: 125 AWHCLGVRSATCGT-----LGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEV 179
               LG R +   T     LG   YD +     TTP  + +   + + R+ G +  A+EV
Sbjct: 124 MLTSLGERGSVLTTAVKRILGNSYYDDI-----TTPDAITILSAMKENREGGGKFFALEV 178

Query: 180 SSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF-AHQDVQAAVINVDD 238
           SSHAL Q RV+GV +DV +FTN++RDHLD+HG  E+Y  AK  LF   +D   AV+N   
Sbjct: 179 SSHALVQQRVEGVRFDVGIFTNISRDHLDFHGTFENYLKAKLHLFDLLKDDGVAVLN--- 235

Query: 239 PFGLRLLHGLAKGMRRVGVSVCGHT--DADVMAQHLSLNLQGIGFDLVIGADHASVRSPL 296
                    LA    R    +   T  +AD    ++ ++ +G  F L        V +  
Sbjct: 236 -------ESLADAFNRKSRKITFGTSKNADYRLGNIEVSWEGTQFVLETPDGLLKVFTRA 288

Query: 297 MGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPV-VVVDYAHT 355
           +G FN  N  A    L+ L Y   ++A+ L T   + GR   + G     + VVVD+AH+
Sbjct: 289 IGDFNAYNAAAAIAALHQLGYDPKDLASSLETFTGVEGRFEVVRGAKKIGLNVVVDFAHS 348

Query: 356 PDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDG 415
           PDAL ++L ++     GR+I VFG GG  DRGKR  M+ +A   ADVV +T D+PRGED 
Sbjct: 349 PDALEKLLKNVRKISQGRVIVVFGAGGNSDRGKRPMMSEVASKLADVVILTTDDPRGEDP 408

Query: 416 DGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRH-P 474
           + I+ D++ G  +     V  DR  AI  A+ IA+  D V+IAG+GHERYQ +   +  P
Sbjct: 409 EQIMEDLIKGIDKRKPYLVLFDRREAIETALTIANRGDSVVIAGRGHERYQIIDEEKKVP 468

Query: 475 FDDTEVARRVL 485
           F D EV   ++
Sbjct: 469 FQDREVVEEII 479


>gi|6093449|sp|O05954|MURE_RICPR
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|2073485|emb|CAA72473| (Y11783) UDP-MurNAc-tripeptide
           synthetase [Rickettsia prowazekii]
           >gi|3861141|emb|CAA15041| (AJ235272)
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--
           2,6-DIAMINOPIMELATE LIGASE (murE) [Rickettsia
           prowazekii]
           Length = 480
           
 Score =  239 bits (604), Expect = 4e-62
 Identities = 162/480 (33%), Positives = 244/480 (50%), Gaps = 29/480 (6%)

Query: 22  ISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAIA 81
           I GL  +S+ V+  + F A+ G    G  FI DA   GAV ++ E      +   D  I 
Sbjct: 14  IKGLSTNSKTVKEDEVFFAIKGQNVDGNDFINDALNNGAVLVITENKNNTAI---DKVIY 70

Query: 82  VHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGV 141
           V  +   L    + F+  P +   ++ VTGTNGK+S V  +AQA+  L  ++A  GT+G+
Sbjct: 71  VEDVHKALYEAIEIFY--PKKPKNLISVTGTNGKSSVVSYIAQAYSLLKKKAAFIGTIGL 128

Query: 142 GLYDQV-----VPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDV 196
            ++        VP+  TT   L   +    L ++  + +A E SSH L+QGR+     ++
Sbjct: 129 EIFGSNNIINDVPS-LTTFDYLSFRKVAHNLAEDSIEYLAFEASSHGLEQGRLGKTKVNI 187

Query: 197 VVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQA--AVINVDDP---FGLRLLHGLAKG 251
           V FT+ ++DHLDYH   E+Y  AK +LF    + +  A++N D     F    LH     
Sbjct: 188 VSFTSFSQDHLDYHHTKENYLLAKLKLFTDHLLPSGIAILNSDIEEIEFVKDYLHNNNVK 247

Query: 252 MRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGV 311
              VG         D+    ++ +L G   D +      ++ + ++G F   NLL  A  
Sbjct: 248 FITVGKK------GDLQITKITCSLTGQNIDFIFNNIIYNLHTLIIGSFQASNLLIAALT 301

Query: 312 LYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVC 371
           LY   +   EI   L+ ++PI GRM R+ G +    + VDY+HTPD+L + L  L +   
Sbjct: 302 LYYTGFKFDEIIEALAKVKPIKGRMERIDGTN----IFVDYSHTPDSLEKALIELKNIKL 357

Query: 372 --GRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARP 429
              +L  +FGCGG+RD+ KR+ M  IA   AD V +TDDNPR ED   I A+I+ G    
Sbjct: 358 HGSKLSVIFGCGGDRDKTKRALMGQIAAKLADNVIITDDNPRFEDPKLIRAEIIRGIGTA 417

Query: 430 NVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVLAAMS 489
              ++   R+ AI   I     +D++LIAGKGHE YQ +   + PFDD+EV R+ L  +S
Sbjct: 418 TYTEI-ASRAEAIKYGINNLKQDDILLIAGKGHETYQIIGDKKLPFDDSEVVRKYLFEIS 476


>gi|3256223|emb|CAA74740| (Y14370) UDP-N-acetylmuramyl-tripeptide
           synthetase [Staphylococcus aureus]
           Length = 492
           
 Score =  225 bits (567), Expect = 8e-58
 Identities = 148/457 (32%), Positives = 230/457 (49%), Gaps = 20/457 (4%)

Query: 22  ISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGA--VAILFEPPAPQGVSVPDGA 79
           I  +  DSR  + G  FVA  G+      F ++   +G   V +  E   P  V+     
Sbjct: 22  IDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQGCKLVVVNKEQSLPANVT----Q 77

Query: 80  IAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTL 139
           + V         +A   + +PS  +   GVTGTNGKTS   ++      L   SA  GT 
Sbjct: 78  VVVPDTLRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATMIHLIQRKLQKNSAYLGTN 137

Query: 140 GVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVF 199
           G  + +       TTP  + L + + +  D GA+++ +EVSSH L  GR+  V +DV +F
Sbjct: 138 GFQINETKTKGANTTPETVSLTKKIKEAVDAGAESMTLEVSSHGLVLGRLRSVEFDVAIF 197

Query: 200 TNLTRDHLDYHGDMEHYGAAKARLFAH--QDV---QAAVINVDDPFGLRLLHGLAKGMRR 254
           +NLT+DHLD+HG ME YG AK+ LF+   +D+   +  V+N DD F   L       +  
Sbjct: 198 SNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKEKYVVLNNDDSFSEYLRTVTPYEVFS 257

Query: 255 VGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYA 314
            G+      +A  MA+++  +LQG+ FD V       V+SP +G+FN+ N++A    +++
Sbjct: 258 YGID----EEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKFNISNIMAAMIAVWS 313

Query: 315 LNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPV-VVVDYAHTPDALGQVLSSLSSHVCGR 373
              +L  I   +  L P+ GR+  L      P+ +++DYAHT D + +++ ++   V  +
Sbjct: 314 KGTSLETIIKAVENLEPVEGRLEVL--DPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQK 371

Query: 374 LICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVK 433
           LI + G  GERD  K  +M  +A   AD V  T DNP  +D   + A++  G    N ++
Sbjct: 372 LIFLVGMAGERDLTKTPEMGRVA-CRADYVIFTPDNPANDDPKMLTAELAKGATHQNYIE 430

Query: 434 VQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAG 470
              DR+  I  AI IA   D V++A KG E YQ + G
Sbjct: 431 FD-DRAEGIKHAIDIAEPGDTVVLASKGREPYQIMPG 466


>gi|6456164|gb|AAF09152.1|AC011622_9 (AC011622) putative
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase [Arabidopsis thaliana]
           Length = 767
           
 Score =  224 bits (565), Expect = 1e-57
 Identities = 157/499 (31%), Positives = 242/499 (48%), Gaps = 44/499 (8%)

Query: 19  DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPD- 77
           DV I+G+  DSR V  GD FV   G       F+ +A  RGAVA++    A + + + D 
Sbjct: 262 DVEITGIQHDSRGVSAGDLFVCCLGSEN----FLSEADKRGAVAVV----ASKEIDIEDT 313

Query: 78  ----GAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRS 133
                 + V    A L A+A  F+ HPS+ M+++GVTGT+GKT+T  L+   +  +GVR+
Sbjct: 314 LGCRALVIVEDTNAVLAALASSFYRHPSKNMSVIGVTGTDGKTTTTYLIKSLYEAMGVRT 373

Query: 134 ATCGTLGVGLYDQV---VPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVD 190
               T+   ++       P     P  + +   +A++   G +++ ME S   L  G+ D
Sbjct: 374 GMFSTVSCYIHGDNKLDTPNATMNPDAVLVQSLMAKMLHNGTESLVMEASPQELALGKCD 433

Query: 191 GVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQ---DVQAAVINVDDPFGLRLLHG 247
            V +D+ VFTNLTR++ D+ G  E Y  A+A+LF+     +    V+N+DDP     +  
Sbjct: 434 EVDFDIAVFTNLTRENTDFRGTDEEYRDAEAKLFSRMVDPERHRKVVNIDDPNAAFFVQ- 492

Query: 248 LAKGMRRVGVSVCG--HTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNL 305
             +G   V V      +T ADV      L+L      +        + S L+GR N+ N+
Sbjct: 493 --QGNPNVPVVTFAMENTKADVHPLKFELSLFETQVLVNTPQGILEISSGLLGRHNIYNI 550

Query: 306 LAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSS 365
           LA   V  A+   L +I   +  +  + GR   +  +    V+V D+A+TPD L ++L S
Sbjct: 551 LAAVAVGIAVGAPLEDIVRGVEEVDAVPGRCELIDEEQAFGVIV-DHANTPDGLSRLLDS 609

Query: 366 LSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAG 425
           +      R+I V GC GE +RGKR  M  IA   +DV  +T DNPR ED   I+ D+L+G
Sbjct: 610 IRELKPRRIITVIGCEGENERGKRPLMTKIATEKSDVTMLTSDNPRNEDPLDILDDMLSG 669

Query: 426 -------------------FARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQ 466
                               A  + + +   R  A+  A+ +    D+V++AGKGHE YQ
Sbjct: 670 IGWTMQEYLKHGEHDYYPPLANGHRLFLHDIRRVAVRCAVAMGEEGDMVVVAGKGHEAYQ 729

Query: 467 EVAGVRHPFDDTEVARRVL 485
                +  +DD E  R  L
Sbjct: 730 LEGEKKEFYDDREECREAL 748


>gi|6093450|sp|O83903|MURE_TREPA
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|3323248 (AE001261)
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase (murE) [Treponema pallidum]
           Length = 540
           
 Score =  216 bits (545), Expect = 3e-55
 Identities = 168/524 (32%), Positives = 251/524 (47%), Gaps = 62/524 (11%)

Query: 22  ISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGV------SV 75
           +S +  DSR V+ G  F A+ G  AHG  +I  A   GA AI+ + P    V       V
Sbjct: 26  VSSIAYDSRAVREGSVFFALRGTHAHGAQYIHAAIDAGACAIVHDCPLDTYVVGVYYARV 85

Query: 76  PDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSAT 135
           PD        R  L + A  F+  P++A+T++GVTGT GK+STV  +AQ     G R   
Sbjct: 86  PDA-------RCALSSAAAAFYDFPTRALTVIGVTGTEGKSSTVSFIAQLLRLCGKRVGF 138

Query: 136 CGTLGVGLYDQVVPTGF--TTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQ--GRVDG 191
             T+   L D ++P     TTP  L + + LA++R+   +   +E SSH L     R+  
Sbjct: 139 ISTVEYSLGDDILPNAEHQTTPESLTVQRLLAEMREHSCEFAVIEASSHGLSTRTARLQD 198

Query: 192 VHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF----AHQDVQAA-------VINVDDPF 240
           V +DV V  N+  +HL++HG  E Y   KA +F    AH  ++         V+  +D  
Sbjct: 199 VAFDVAVCMNVRHEHLEFHGSFEQYRFDKANVFRALDAHDHIKDGRRVPSFGVLWAEDAS 258

Query: 241 GLRLLHGLAKG-----------------MRRVGVSVCGHTDADVMAQHLSLN-----LQG 278
            +       K                  + R+  ++        ++Q L L      +Q 
Sbjct: 259 AVYFREATHKPCFFFKRGTGAEQRTAACLERMPCTLLWVQTLPQISQALRLRFVLSTVQE 318

Query: 279 IGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYAL-NYALSEIAAVLSTLRPIHGRMN 337
                  GA   SV  PL G FN  N+ A   VL+ L   +L+  A  +  ++PI GRM 
Sbjct: 319 PAQPAQDGAHDVSV--PLEGAFNACNIAASFLVLHGLLGTSLAAFAQHVQYVQPIQGRMQ 376

Query: 338 RLG-GQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGR---LICVFGCGGERDRGKRSQMA 393
           R+  GQD +  V++DYAHTP +  ++L  L++ V  R   ++ +FG  GERD  KR+   
Sbjct: 377 RVDMGQDFE--VLIDYAHTPSSFEEILPPLAARVRARKRRMLVLFGSAGERDTQKRAMQG 434

Query: 394 VIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVK---VQRDRSAAIAAAIGIAS 450
            IA   A V+ +TD++PRGED  GI+  I AG     + K   +  DR AA+     +A 
Sbjct: 435 AIASRYAHVIVLTDEDPRGEDPMGILCMIAAGCEHKKLGKTLFLIPDRVAALRHIFSLAR 494

Query: 451 AEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVLAAMSAQETV 494
           A+D+VL+ GKGHE     A    P+D+   AR +L A  + +T+
Sbjct: 495 AQDLVLLLGKGHEHSIIYAHTVQPYDEERTARELLRASLSSDTL 538


>gi|6969058|emb|CAB73629.1| (AL139079)
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diami ligase
           [Campylobacter jejuni]
           Length = 427
           
 Score =  199 bits (502), Expect = 3e-50
 Identities = 129/389 (33%), Positives = 202/389 (51%), Gaps = 27/389 (6%)

Query: 102 QAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYD-QVVPTGFTTPLVLQL 160
           + + ++G+TGTNGKT+T   +      LG +   CGT G  + D Q+     TT  +L+ 
Sbjct: 57  EKIQIIGITGTNGKTTTAAAIYSILLDLGYKCGLCGTRGAFINDEQIDEKSLTTSPILKT 116

Query: 161 HQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAK 220
            + L     +      MEVSSHAL Q R++G+++   +FTN+T+DHLD+HG  E+Y  AK
Sbjct: 117 LEYLQIATQKKCDFFIMEVSSHALVQNRIEGLNFAAKIFTNITQDHLDFHGTFENYKEAK 176

Query: 221 ARLFAHQDVQAAVINVDD---PFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQ 277
              F  + ++   IN D     F +R  +    G+    +         + A  L    +
Sbjct: 177 ELFFTDESLK--FINKDALAIKFNVR--NAFTYGIENPALY-------QIKAYSLE---E 222

Query: 278 GIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYAL-NYALSEIAAVLSTLRPIHGRM 336
           GI   +        + SPL+G FN+ NLL  +  +  L    L ++   +S    + GR+
Sbjct: 223 GISTIVTNKNQTFHIDSPLLGLFNLYNLLVASACVNELVKPDLKDLEKAISGFGGVCGRV 282

Query: 337 NRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIA 396
            ++        V+VD+AHTPD + +VL +L +    +LI VFG GG+RD+ KR  M  I 
Sbjct: 283 EQVAKG-----VIVDFAHTPDGIEKVLDTLKNK---KLIVVFGAGGDRDKTKRPLMGKIV 334

Query: 397 ESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVL 456
           E  A +  +T DNPR E+   I+ +IL+GF +   V +  DR  AI  A+ +   +D+V+
Sbjct: 335 EHFAKIAIITSDNPRSEEPKTIMEEILSGFTKKEKVLMIEDRKEAIKKALELKENDDLVV 394

Query: 457 IAGKGHERYQEVAGVRHPFDDTEVARRVL 485
           I GKG E  QE+ G+++PF D  V   +L
Sbjct: 395 ILGKGDETTQEIKGIKYPFSDKVVVNEIL 423


>gi|4156007 (AE001561) UDP-N-ACETYLMURAMYL-TRIPEPTIDE SYNTHETASE
           [Helicobacter pylori J99]
           Length = 447
           
 Score =  190 bits (478), Expect = 2e-47
 Identities = 134/388 (34%), Positives = 200/388 (51%), Gaps = 29/388 (7%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQ-VVPTGFTTPLVLQLHQCL 164
           +VG+TGTNGKT+T  L+      L  ++A  GT G  + D+ +   G TTP +L+L+  L
Sbjct: 69  IVGITGTNGKTTTASLMYSLLLDLNKKTALLGTRGFFIDDKHIKEKGLTTPTLLELYSDL 128

Query: 165 AQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF 224
            +      +   MEVSSHA+ Q R+ G+ + + + TN+T DHLD+H ++E+Y  AK   F
Sbjct: 129 EEAIRLKCEYFIMEVSSHAIVQKRIAGLDFALKILTNITSDHLDFHQNIENYRDAKNSFF 188

Query: 225 AHQDVQAAVINVDD------PFGLRLLHGLAKGMRRV-GVSVCGHTDADVMAQH--LSLN 275
             + ++  VIN D+      P   R      K    V   S+     A +  QH     N
Sbjct: 189 KDEGLK--VINRDETNALFNPINARTYALDKKAHLNVQAFSLNPSISASLCYQHDLRDPN 246

Query: 276 LQGIGFDLVIGADHASVRSPLMGRFNVDNLLA-VAGVLYALNYALSEIAAVLSTLRPIHG 334
           L+          + A + SPL+GR+N+ N+LA V GV       L  IA +L     + G
Sbjct: 247 LK----------ETALIHSPLLGRYNLYNILAGVLGVKLLTQLPLETIAPLLENFYGVKG 296

Query: 335 RMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAV 394
           R+  +     +P+VVVD+AHT D + QV  S  +    ++  +FG GG+RD+ KR +M  
Sbjct: 297 RLEIV---HSKPLVVVDFAHTTDGMQQVFESFKNQ---KITALFGAGGDRDKTKRPKMGA 350

Query: 395 IAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDV 454
           IA   A  + +T DNPR E+ + I+ DIL G    + V V++DR  AI  A+     ++V
Sbjct: 351 IASCYAHQIILTSDNPRSENEEDIIKDILKGINNSSKVIVEKDRKKAILNALENLKDDEV 410

Query: 455 VLIAGKGHERYQEVAGVRHPFDDTEVAR 482
           +LI GKG E  Q        F D EV +
Sbjct: 411 LLILGKGDENIQIFKDKTIFFSDQEVVK 438


>gi|2314673|gb|AAD08535.1| (AE000648) UDP-MurNac-tripeptide
           synthetase (murE) [Helicobacter pylori 26695]
           Length = 447
           
 Score =  187 bits (469), Expect = 2e-46
 Identities = 133/393 (33%), Positives = 198/393 (49%), Gaps = 39/393 (9%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQ-VVPTGFTTPLVLQLHQCL 164
           +VG+TGTNGKT+T  L+      L  ++A  GT G  + ++ +   G TTP +L+L+  L
Sbjct: 69  IVGITGTNGKTTTASLMYSLLLDLNKKTALLGTRGFFINNERIKEKGLTTPTLLELYSDL 128

Query: 165 AQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF 224
            +      +   MEVSSHA+ Q R+ G+ + + + TN+T DHLD+H  +E+Y  AK   F
Sbjct: 129 EEAVRLKCEYFIMEVSSHAIVQKRIAGLDFALKILTNITSDHLDFHQSIENYRDAKNSFF 188

Query: 225 AHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLV 284
             + ++  VIN D+   L                V  HT A     HL  N+Q    +  
Sbjct: 189 KDEGLK--VINRDETNALFN-------------PVNAHTYALDKKAHL--NVQAFSLNPS 231

Query: 285 IGA--------------DHASVRSPLMGRFNVDNLLA-VAGVLYALNYALSEIAAVLSTL 329
           I A              + A + SPL+GR+N+ N+LA V GV       L  I  +L   
Sbjct: 232 ISASLCYQQDLRDPNFKEIALMHSPLLGRYNLYNILAGVLGVKLLTQLPLETIVPLLENF 291

Query: 330 RPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKR 389
             + GR+  +     +P+VVVD+AHT D + QV  S  +    ++  +FG GG+RD+ KR
Sbjct: 292 YGVKGRLEIV---HSKPLVVVDFAHTIDGMQQVFESFKNQ---KITALFGAGGDRDKTKR 345

Query: 390 SQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIA 449
            +M  IA   A  + +T DNPR E+ + I+ DIL G    + V V++DR  AI  A+   
Sbjct: 346 PEMGAIASYYAHKIILTSDNPRSENEEDIIKDILKGINDSSKVIVEKDRKKAILNALENL 405

Query: 450 SAEDVVLIAGKGHERYQEVAGVRHPFDDTEVAR 482
             ++V+LI GKG E  Q        F D EV +
Sbjct: 406 KDDEVLLILGKGDENIQIFKDKTIFFSDQEVVK 438


>gi|3914073|sp|O51219|MURE_BORBU
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|2688092 (AE001130)
           UDP-N-acetylmuramoylalanyl-D-glutamate--2,
           6-diaminopimelate ligase (murE) [Borrelia burgdorferi]
           Length = 508
           
 Score =  180 bits (452), Expect = 2e-44
 Identities = 147/506 (29%), Positives = 236/506 (46%), Gaps = 39/506 (7%)

Query: 10  LLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAIL----- 64
           L+  +  + D+ ISG+   S+ V P   F A+ G    G  FIE A  +G+  ++     
Sbjct: 16  LIKCVKGSLDLEISGVTYSSKLVLPRFVFFALPGIHFDGHDFIEIAIQKGSNVVVCSRDV 75

Query: 65  -FEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLA 123
            F  P    + V D       +R  +   ++ F+  PS+ + ++GVTGT+GK+S    + 
Sbjct: 76  DFYSPNVTYIKVDD-----FNIRKFMSNFSNIFYDEPSKKLKVIGVTGTDGKSSVCYYIY 130

Query: 124 QAWHCLGVRSATCGTL----GVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEV 179
             +   GV+     T+    G G   +  P   +TP   ++H  L+ +    AQ   +E 
Sbjct: 131 LLFKKKGVKVGFISTVFFDDGSGSLIKN-PYRQSTPESTEIHSFLSTMVKNEAQYAILES 189

Query: 180 SSHALD--QGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF--AHQDVQAAVIN 235
           +SH LD    R+  V+Y  VVFTN+  +HL++HG +++Y   K  LF     D    VIN
Sbjct: 190 TSHGLDLETARLIDVNYFAVVFTNIGHEHLEFHGTIQNYLNVKLGLFRSVSDDAGFGVIN 249

Query: 236 VDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSP 295
           +DD +     + + K       S    + AD     +        F+             
Sbjct: 250 LDDLYSSDFKNAVKKSFTYSLKS----SKADFFVSFIDEKTDSTRFEFYHKGVKYLANVS 305

Query: 296 LMGRFNVDNLLA-VAGVLYALNYALSEIAAVLSTLRPIHGRMNRLG-GQDGQPVVVVDYA 353
           L+G FNV+N++A +  V   LN  + +I   L+ ++ + GRM+ +  GQ+    V++DYA
Sbjct: 306 LLGSFNVENVMAALILVSQILNIDIQDIVDKLNCIKSLDGRMDSINLGQNFS--VIIDYA 363

Query: 354 HTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGE 413
           HTP A  ++          RLI VFG  GERD  KR     IA+  +D++ + D++PRGE
Sbjct: 364 HTPGAFSKLFPIFKRFATNRLISVFGSAGERDVEKRFLQGQIADIYSDLIILCDEDPRGE 423

Query: 414 DGDGIVADILAGFARPNVVKVQR-------DRSAAIAAAIGIASAEDVVLIAGKGHERYQ 466
           +   I+ DI  G     V KV+        DR  AI  AI +A A D+V+  GKGHE   
Sbjct: 424 NSMCIIKDIAKGI----VNKVENKDLFFIADRKQAIEKAISLAKAGDLVVALGKGHESSI 479

Query: 467 EVAGVRHPFDDTEVARRVLAAMSAQE 492
                   +++ EV +  + ++   E
Sbjct: 480 IYKNREVFWNEQEVVKNAILSLEKSE 505


>gi|6093446|sp|O85298|MURE_BUCAP
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|3435169|gb|AAC32338| (AF060492) meso-diaminopimelate
           adding enzyme [Buchnera aphidicola]
           Length = 292
           
 Score =  137 bits (342), Expect = 2e-31
 Identities = 83/247 (33%), Positives = 129/247 (51%), Gaps = 9/247 (3%)

Query: 10  LLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPA 69
           L P I        S L +DSR++   D F+A+ G    G  FI +A  +  VAIL E   
Sbjct: 10  LFPWIKNTPQKKFSNLSLDSRKLTSKDVFIAIKGTKKDGNDFIFEAVKKRVVAILSETKE 69

Query: 70  PQGV-------SVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLL 122
            +         ++P   ++   L  ++  +A R +  P++ + ++GVTGTNGKT+  QL+
Sbjct: 70  KKKHGEINYINNIP--ILSFFKLSEKISNLAARVYKEPAKTLKIIGVTGTNGKTTVTQLI 127

Query: 123 AQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSH 182
            Q    LG + AT GTLG G Y+ +  T  TT   + +   L     +    V MEVSSH
Sbjct: 128 NQWSELLGKKIATMGTLGNGFYNALKTTKNTTSSAIDIQSFLHIAAKKKINLVTMEVSSH 187

Query: 183 ALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGL 242
            L Q RV  + + + +FTNLT+DHLDYH +M+ Y +AK   F+   ++  ++N +D +  
Sbjct: 188 GLVQNRVKNIPFYIGIFTNLTQDHLDYHKNMKQYESAKWSFFSQHKIKKIILNANDKYAK 247

Query: 243 RLLHGLA 249
           + L  L+
Sbjct: 248 KWLRKLS 254


>gi|6093447|sp|O69290|MURE_CAMJE
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,
           6-DIAMINOPIMELATE LIGASE (UDP-N-ACETYLMURAMYL-TRIPEPTIDE
           SYNTHETASE) (MESO-DIAMINOPIMELATE-ADDING ENZYME)
           >gi|2959999|emb|CAA76495| (Y16882)
           UDP-N-acetylmuramoylalanyl-D-glutamate--
           2,6-diaminopimelate ligase [Campylobacter jejuni]
           Length = 350
           
 Score =  115 bits (286), Expect = 7e-25
 Identities = 88/290 (30%), Positives = 141/290 (48%), Gaps = 23/290 (7%)

Query: 102 QAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYD-QVVPTGFTTPLVLQL 160
           + + ++G+TGTNGKT+T   +      LG +   CGT G  + D Q+     TT  +L+ 
Sbjct: 81  EKIQIIGITGTNGKTTTAAAIYSILLDLGYKCGLCGTRGAFINDEQIDEKSLTTSPILKT 140

Query: 161 HQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAK 220
            + L     +      M VSSHAL   R +G+++   +FTN+T+DHLD+ G   +Y  AK
Sbjct: 141 LEYLLIATPKKCDFFIMGVSSHALVPNRSEGLNFAAKIFTNITQDHLDFRGTFGNYKEAK 200

Query: 221 ARLFAHQDVQAAVINVDD-PFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGI 279
              F  + ++   IN D       + +    G+    +         + A  L    +GI
Sbjct: 201 ELFFTDESLK--FINKDALAIKFNVRNAFTYGIENPAL-------YQIKAYSLE---EGI 248

Query: 280 GFDLVIGADHASVRSPLMGRFNVDNLL-AVAGVLYALNYALSEIAAVLSTLRPIHGRMNR 338
              +        + SPL+G FN+ NLL A A V   +   L ++   +S    + GR+ +
Sbjct: 249 STIVTNKNQTFHIDSPLLGLFNLYNLLVASACVNELVKPDLKDLEKAISGFGGVCGRVEQ 308

Query: 339 LGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGK 388
           +        V+VD+AHTPD + +VL +L +    +LI VFG GG+RD+ K
Sbjct: 309 VA-----KGVIVDFAHTPDGIEKVLDTLKNK---KLIVVFGAGGDRDKTK 350


>gi|5689960|emb|CAB51997.1| (AL109663) putative
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate-D -alanyl-alanyl ligase [Streptomyces
           coelicolor A3(2)]
           Length = 471
           
 Score = 96.3 bits (236), Expect = 5e-19
 Identities = 113/370 (30%), Positives = 155/370 (41%), Gaps = 38/370 (10%)

Query: 13  DIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQG 72
           DIP A   V   +V DSRE  PG  FVA  G  A G  F       GAVA+L   P    
Sbjct: 19  DIPDASAEVTGPVVRDSREAGPGSLFVAFVGERADGHDFAARVVEAGAVAVLGSRP---- 74

Query: 73  VSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVR 132
           V VP  AI V  ++A LGA+A   H       T+V +TG+ GKTST  L+AQ        
Sbjct: 75  VGVP--AIVVDDVQAALGALAR--HVVRRLGTTLVALTGSAGKTSTKDLIAQVLRRKAPT 130

Query: 133 SATCGTLG--VGL-YDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRV 189
             T G++   VGL    +  T  T  LVL++          GA+ +        L   ++
Sbjct: 131 VFTPGSMNNEVGLPLTALTATDETKFLVLEM----------GARGIGHIRYLTELTPPKI 180

Query: 190 DGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF----AHQDVQAAVINVDDPFGLRLL 245
             V        N+   H+   G  E    AK  L       ++  AA++N DDP    L+
Sbjct: 181 GAV-------LNVGSAHIGEFGGREQIAQAKGELVEALPPAEEGGAAILNADDP----LV 229

Query: 246 HGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQG-IGFDLVIGADHASVRSPLMGRFNVDN 304
             +A   +   +      +ADV A+++ L   G   F L   +  + V   L G  +V N
Sbjct: 230 RAMASRTKAKVILFGESGEADVRAENVRLTDTGQPSFSLHTPSGASDVTMRLYGEHHVSN 289

Query: 305 LLAVAGVLYALNYALSEIAAVLSTLRPI-HGRMNRLGGQDGQPVVVVDYAHTPDALGQVL 363
            LA A V + L  +  EIA  LS    +   RM      DG  VV   Y   P++    L
Sbjct: 290 ALAAAAVAHELGMSADEIATALSEAGSLSRWRMEVTERPDGVTVVNDAYNANPESTKAAL 349

Query: 364 SSLSSHVCGR 373
            +L +   GR
Sbjct: 350 RALVAMGKGR 359


>gi|2621604 (AE000836) UDP-N-acetylmuramyl tripeptide synthetase
           related protein [Methanobacterium thermoautotrophicum]
           Length = 682
           
 Score = 87.0 bits (212), Expect = 3e-16
 Identities = 112/408 (27%), Positives = 162/408 (39%), Gaps = 73/408 (17%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +VGVTGTNGKT+T  +L       G+R      L +    ++VP      L  +L   +A
Sbjct: 298 VVGVTGTNGKTTTTGMLKSIMRVAGMRVPE-HHLNIQGNTELVPA-----LQARLPGDVA 351

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFA 225
            + + G      E+ S A+  G        V V TN++RDHL        Y   K  +  
Sbjct: 352 VV-EIGTFGRRGEIRSSAMLSG------VSVGVITNISRDHLSAGRRFSDYIECKGEMV- 403

Query: 226 HQDVQAAVINVDDPFGLRLLHGLAKGM--------------------------------R 253
            +  +  V+N DDP    L  GL +                                  R
Sbjct: 404 -EVAEDLVLNADDPIVASLADGLPRERVVFYGIQSSESGGVVPEGRECPKCGKPLRYTRR 462

Query: 254 RVG-----VSVCGHT--DADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLL 306
            +G       +CG+     DVMA   S      GF LVIG +   VR    G FNV N L
Sbjct: 463 TIGHLGDYQCICGYLRPQPDVMAIEASPG----GFKLVIGQEMREVRLATPGIFNVYNAL 518

Query: 307 AVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSL 366
           A A   + +   + +I   L + + + GR   L      P +++DYAH P  +  V+  L
Sbjct: 519 AAAATAWTMGLEIDDIVRGLESFKGVPGRFQEL---SESPRIILDYAHNPAGVRAVMQDL 575

Query: 367 SSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPR------GEDGDGIVA 420
                GRLI V     E       ++A I + +ADVV       R      GE    I +
Sbjct: 576 RGK--GRLIVVNTVASESGIDGDREIAAILK-DADVVIPASYAARRASDILGERAVHIGS 632

Query: 421 DILAGFARPNVVKVQRDRSA-AIAAAIGIASAEDVVLIAGKGHERYQE 467
             +   A    +   R++ A A+  A+ +A  +D VLI G+G  RY E
Sbjct: 633 SRMR--AGGGTLGASREQVAEAVRKALELAGPDDTVLIIGEGGYRYAE 678


 Score = 43.0 bits (99), Expect = 0.006
 Identities = 41/165 (24%), Positives = 67/165 (39%), Gaps = 5/165 (3%)

Query: 298 GRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPD 357
           G FN++N LA   V   L + + +I   +   R I GR   +   DG   V +D AH P+
Sbjct: 14  GIFNIENALAAITVALILGFDMEDIKRSIEDFRGIRGRFEFIDEVDGVR-VYMDAAHNPE 72

Query: 358 ALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDG 417
           ++ ++   +     GRLI             + ++  +    A  + V+  N      D 
Sbjct: 73  SMEKLFEGMEFQ--GRLIVSLDNPDTLTVRDKERIGRVLAERAHTIIVSAKNETTGVTDM 130

Query: 418 IVADILA-GFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKG 461
             AD +A G      +K +     +I  A+ IA   D +L  G G
Sbjct: 131 EAADEVAWGAGEERTIKTESVYD-SIRRALEIAEPGDTILHIGPG 174


>gi|3122417|sp|O33804|MURF_STRTO PROBABLE
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME) >gi|2228594 (U82965)
           MurX [Streptomyces toyocaensis]
           Length = 443
           
 Score = 81.1 bits (197), Expect = 2e-14
 Identities = 132/462 (28%), Positives = 179/462 (38%), Gaps = 59/462 (12%)

Query: 21  VISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAI 80
           V +  V+DSR+ +PG  F   AG  A G  + E A   GAVA+L   P     S+P   +
Sbjct: 24  VTAPAVLDSRQAEPG-GFCRFAGEHADGHDYAERAGRAGAVAVLGSRPT----SLP--TV 76

Query: 81  AVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLG 140
            V  +R  L  +A          +T+VGVTG+ GKT T  LLA      G   AT G+L 
Sbjct: 77  VVEDVRTALQTLAAHVVARLRDGLTVVGVTGSQGKTGTKDLLAAVLSAHGPTVATTGSLN 136

Query: 141 VGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGA-QAVAMEVSS-HALDQGRVDG-VHYDVV 197
                             +L   L  LR + A + + +E+ + H  D   + G V  D+ 
Sbjct: 137 -----------------NELGVPLTMLRAQAATRFLVLEMGARHEGDIAELTGLVAPDIA 179

Query: 198 VFTNLTRDHLDYHGDMEHYGAAKARLF-AHQDVQAAVINVDDPFGLRLLHGLAKGMRRVG 256
           V  N+   H+   G       AK  L         AV+N DDP  +  +  L  G     
Sbjct: 180 VVLNVGVAHVGEFGSRAAIARAKGELVQGLVPGGTAVLNADDP-RVASMSVLTDG----P 234

Query: 257 VSVCGHTD-ADVMAQHLSLNLQGIG---FDLVIGADHASVRSPLMGRFNVDNLLAVAGVL 312
           V   G TD ADV  Q L +   G+G     L      A +  PL+G     N  A A   
Sbjct: 235 VLTFGRTDPADV--QVLDVVFDGLGRPSCTLRTVDTSARLALPLVGAHQALNASAAAAAA 292

Query: 313 YALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALG-QVLSSLSSHVC 371
            A    L      L+T R   G  N      G    V++ + TP       L +LS+   
Sbjct: 293 LAAGVPLDLATTALTTARCRRGGWNCATSLRGD---VLNDSTTPTRTDPAALDALSAIEG 349

Query: 372 GRLICVFGCG---GERDRGKRSQMAVIAESNADVVFVTDDNPRG-EDGDGIVADILAGFA 427
           GR I V G     G+    +   +   A + ADVV    +  R   DG G  A + AG  
Sbjct: 350 GRRIAVLGEMLELGDGSEAEHRAVGAYAAARADVVVAVGEAARPFADGAGERAVVFAG-- 407

Query: 428 RPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVA 469
                       AA+       +A DVVL+      R  EVA
Sbjct: 408 ----------NDAAVDWLRDHLAAGDVVLVKASRGARLDEVA 439


>gi|5689958|emb|CAB51995.1| (AL109663) putative
           UDP-N-acetylmuramoylalanine-D-glutamate ligase
           [Streptomyces coelicolor A3(2)]
           Length = 471
           
 Score = 76.1 bits (184), Expect = 6e-13
 Identities = 74/247 (29%), Positives = 109/247 (43%), Gaps = 36/247 (14%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           + VTGTNGKT+TVQ+LA      G+R+A  G +GV L D V  TG               
Sbjct: 118 LAVTGTNGKTTTVQMLASILKAAGLRTAAVGNIGVSLLDAV--TG--------------- 160

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH 226
             ++    +A+E+SS+ L        H   V+  NL  DHLD+HG ME Y A K R++  
Sbjct: 161 --EQEYDVLAVELSSYQLHWAPSLRAHSAAVL--NLAPDHLDWHGSMEAYAADKGRIYEG 216

Query: 227 QDVQAAVINVDDPFGLRLLHG--LAKGMRRVGV-------SVCGHTDADVMAQHLSLNLQ 277
             V A V NV D     L+    + +G R +G        S  G  +  ++ +    + Q
Sbjct: 217 NHV-ACVYNVADKATEDLVRAADVEEGCRAIGFTLGTPGPSQLGVVEGLLVDRAFVEDRQ 275

Query: 278 GIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMN 337
               +L   A+ + V  P     N+ N LA AG+  A   + + +   L    P   R+ 
Sbjct: 276 KNAQEL---AEVSDVNPP--APHNIANALAAAGLARAFGVSAAAVRDGLRAFTPDAHRIA 330

Query: 338 RLGGQDG 344
            +   DG
Sbjct: 331 HVADVDG 337


>gi|96537|pir||S10691 UDP-N-acetylmuramyl-tripeptide synthetase -
           Escherichia coli (fragment) >gi|581175|emb|CAA39334|
           (X55814) UDP-N-acetylmuramyl-tripeptide synthetase
           [Escherichia coli]
           Length = 124
           
 Score = 73.7 bits (178), Expect = 3e-12
 Identities = 48/118 (40%), Positives = 61/118 (51%), Gaps = 13/118 (11%)

Query: 10  LLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPA 69
           L P +P A    +  + +DSR    GD FVAV G  A G  +I  A A+G  AI+ E   
Sbjct: 10  LAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKD 69

Query: 70  PQGVSVPDGAIA-VHG--------LRARLGAMADRFHGHPSQAMTMVGVTGTNGKTST 118
                  DG I  +HG        L  RL A+A RF+  PS  + +VGVTGTNGKT+T
Sbjct: 70  ----EATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTT 123


>gi|2507071|sp|P11880|MURF_ECOLI
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME) >gi|1743865 (U67891)
           UDP-MurNAc-Tripeptide:D-Ala-D-Ala-Adding enzyme
           [Escherichia coli] >gi|1786274 (AE000118)
           D-alanine:D-alanine-adding enzyme [Escherichia coli]
           Length = 452
           
 Score = 72.2 bits (174), Expect = 9e-12
 Identities = 89/337 (26%), Positives = 137/337 (40%), Gaps = 35/337 (10%)

Query: 7   LAQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAG--FGAHGLCFIEDACARGAVAIL 64
           L  +L    Q  D+ +  +  D+R++ PG  FVA+ G  F AH   F + A A GA A+L
Sbjct: 9   LTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHD--FADQAKAGGAGALL 66

Query: 65  FEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQ 124
                P  + +P   + V   R   G +A            +V +TG++GKTS  ++ A 
Sbjct: 67  VS--RPLDIDLPQ--LIVKDTRLAFGELAAWV--RQQVPARVVALTGSSGKTSVKEMTAA 120

Query: 125 AWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHAL 184
                G    T G L     D  VP              L +L  E   AV    ++H  
Sbjct: 121 ILSQCGNTLYTAGNLN---NDIGVP------------MTLLRLTPEYDYAVIELGANH-- 163

Query: 185 DQGR----VDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH-QDVQAAVINVDDP 239
            QG     V     +  +  NL   HL+  G +     AK  +F+   +   A++N D+ 
Sbjct: 164 -QGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNN 222

Query: 240 FGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGR 299
             L     +  G R+V        ++D  A ++ +   G  F L        V  PL GR
Sbjct: 223 DWLNWQSVI--GSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGR 280

Query: 300 FNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRM 336
            N+ N LA A +  ++   L  I A L+ L+ + GR+
Sbjct: 281 HNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRL 317


>gi|2177096 (U67893) UDP-MurNAc-Tripeptide:D-Ala-D-Ala-Adding Enzyme
           [Escherichia coli]
           Length = 452
           
 Score = 70.6 bits (170), Expect = 3e-11
 Identities = 88/337 (26%), Positives = 136/337 (40%), Gaps = 35/337 (10%)

Query: 7   LAQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAG--FGAHGLCFIEDACARGAVAIL 64
           L  +L    Q  D+ +  +  D+R++ PG  FVA+ G  F AH   F + A A GA A+L
Sbjct: 9   LTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHD--FADQAKAGGAGALL 66

Query: 65  FEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQ 124
                P  + +P   + V   R   G +A            +V +TG++GKTS  ++ A 
Sbjct: 67  VS--RPLDIDLPQ--LIVKDTRLAFGELAAWV--RQQVPARVVALTGSSGKTSVKEMTAA 120

Query: 125 AWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHAL 184
                G    T G L     D  VP              L +L  E   AV    ++H  
Sbjct: 121 ILSQCGNTLYTAGNLN---NDIGVP------------MTLLRLTPEYDYAVIELGANH-- 163

Query: 185 DQGR----VDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH-QDVQAAVINVDDP 239
            QG     V     +  +  NL   HL+  G +     AK  +F+   +   A++N D+ 
Sbjct: 164 -QGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNN 222

Query: 240 FGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGR 299
             L     +  G R+V        ++D  A ++ +   G  F L        V  PL GR
Sbjct: 223 DWLNWQSVI--GSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGR 280

Query: 300 FNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRM 336
            N+ N L  A +  ++   L  I A L+ L+ + GR+
Sbjct: 281 HNIANALTAAALSMSVGATLDAIKAGLANLKAVPGRL 317


>gi|3122402|sp|O06220|MURF_MYCTU
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME)
           >gi|2104321|emb|CAB08670| (Z95388) murF [Mycobacterium
           tuberculosis]
           Length = 510
           
 Score = 70.2 bits (169), Expect = 4e-11
 Identities = 101/369 (27%), Positives = 145/369 (38%), Gaps = 44/369 (11%)

Query: 22  ISGLV-MDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAI 80
           ++G V  DSR + PG  F+A+ G  A G      A A GA  +L   P      V     
Sbjct: 30  VTGTVEFDSRAIGPGGLFLALPGARADGHDHAASAVAAGAAVVLAARPVGVPAIVVPPVA 89

Query: 81  AVHGLR------------ARLGAMADRFHGHPSQ----AMTMVGVTGTNGKTSTVQLLAQ 124
           A + L             A L A+A       +Q     +T++G+TG++GKTST  L+A 
Sbjct: 90  APNVLAGVLEHDNDGSGAAVLAALAKLATAVAAQLVAGGLTIIGITGSSGKTSTKDLMAA 149

Query: 125 AWHCLGVRSATCGTLGVGL---YDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSS 181
               LG   A  G+    L   +  +  T  T  L+L++       R  G  A   E++ 
Sbjct: 150 VLAPLGEVVAPPGSFNNELGHPWTVLRATRRTDYLILEM-----AARHHGNIAALAEIAP 204

Query: 182 HALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL-FAHQDVQAAVINVDDPF 240
            ++             V  N+   HL   G  E     KA L  A     A V+N DDP 
Sbjct: 205 PSIG------------VVLNVGTAHLGEFGSREVIAQTKAELPQAVPHSGAVVLNADDP- 251

Query: 241 GLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLN-LQGIGFDLVIGADHASVRSPLMGR 299
               +  +AK      V V      DV A  +SL+ L    F L      A VR  + G 
Sbjct: 252 ---AVAAMAKLTAARVVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAEVRLGVCGD 308

Query: 300 FNVDNLLAVAGVLYALNYALSEIAAVLSTLRPI-HGRMNRLGGQDGQPVVVVDYAHTPDA 358
             V N L  A V      ++ ++AA L+   P+   RM      DG  V+   Y   PD+
Sbjct: 309 HQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDDAYNANPDS 368

Query: 359 LGQVLSSLS 367
           +   L +L+
Sbjct: 369 MRAGLQALA 377


>gi|78921|pir||S04846 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate--D-alanyl-D-alanine ligase (EC
           6.3.2.15) precursor - Escherichia coli
           >gi|40854|emb|CAA38863.1| (X55034)
           UDP-MurNac-pentapeptide presynthetase (AA -20 to 432)
           [Escherichia coli] >gi|42048|emb|CAA33473| (X15432)
           UDP-MurNAC-pentapeptide presynthetase (AA -20 to 432)
           [Escherichia coli] >gi|216500|dbj|BAA01351| (D10483)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate-D-alanyl D alanine ligase precursor
           [Escherichia coli]
           Length = 452
           
 Score = 69.9 bits (168), Expect = 5e-11
 Identities = 83/333 (24%), Positives = 133/333 (39%), Gaps = 27/333 (8%)

Query: 7   LAQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAG--FGAHGLCFIEDACARGAVAIL 64
           L  +L    Q  D+ +  +  D+R++ PG  FVA+ G  F AH   F + A A  A A+L
Sbjct: 9   LTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHD--FADQAKAGAAGALL 66

Query: 65  FEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQ 124
                P  + +P   + V   R   G +A            +V +TG++GKTS  ++ A 
Sbjct: 67  VS--RPLDIDLPQ--LIVKDTRLAFGELAAWV--RQQVPARVVALTGSSGKTSVKEMTAA 120

Query: 125 AWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHAL 184
                G    T G L   +   +     T      + +  A  + E A  V++     AL
Sbjct: 121 ILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPERAL 180

Query: 185 DQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH-QDVQAAVINVDDPFGLR 243
                           NL   HL+  G +     AK  +F+   +   A++N D+   L 
Sbjct: 181 --------------VNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLN 226

Query: 244 LLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVD 303
               +  G R+V        ++D  A ++ +   G  F L        V  PL GR N+ 
Sbjct: 227 WQSVI--GSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIA 284

Query: 304 NLLAVAGVLYALNYALSEIAAVLSTLRPIHGRM 336
           N LA A +  ++   L  I A L+ L+ + GR+
Sbjct: 285 NALAAAALSMSVGATLDAIKAGLANLKAVPGRL 317


>gi|6225735|sp|Q9ZDC2|MURD_RICPR
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME)
           >gi|3860967|emb|CAA14867| (AJ235271)
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE (murD)
           [Rickettsia prowazekii]
           Length = 445
           
 Score = 66.7 bits (160), Expect = 4e-10
 Identities = 61/243 (25%), Positives = 105/243 (43%), Gaps = 34/243 (13%)

Query: 101 SQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQL 160
           S+ +  + +TGTNGK++T  L++   +  G+     G +GV                   
Sbjct: 101 SKNLKFIAITGTNGKSTTTALISHILNSNGLDYPVAGNIGVPALQ--------------- 145

Query: 161 HQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAK 220
               A+  +EG     +E+SS  LD   V      V V  N+T DHLD + DM  Y AAK
Sbjct: 146 ----AKASNEG---YVLELSSFQLDL--VKSFTVKVAVLLNITPDHLDRYQDMNDYIAAK 196

Query: 221 ARLFAHQDVQA-AVINVDDPFGLRLLHGLAK--GMRRVGVSVCGHTDADVMAQHLSLNLQ 277
           A++F   D  + AVIN+D+ +  ++   L K   ++ +  SV       +      ++  
Sbjct: 197 AKIFDRMDKDSYAVINIDNDYCRKIFVLLQKDQSIKLIPFSVTKILKNGISIVDDKIHDN 256

Query: 278 GIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMN 337
            + + L +  +       L G  N +N+ A   V   +     +I   +S+ + +H RM 
Sbjct: 257 DLTYKLPLNKN-------LQGLHNCENIAASYAVAKIIGLESKKILESISSFQSLHHRMQ 309

Query: 338 RLG 340
            +G
Sbjct: 310 YIG 312


>gi|5834369|gb|AAD53935.1|AF179611_19 (AF179611)
           UDP-N-acetylmuramate-alanine ligase [Zymomonas mobilis]
           Length = 486
           
 Score = 66.0 bits (158), Expect = 7e-10
 Identities = 95/375 (25%), Positives = 151/375 (39%), Gaps = 51/375 (13%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           V V GT+GKT+T  ++A               L  G  D  V  G     ++  +   A+
Sbjct: 111 VAVAGTHGKTTTTSMVA-------------ALLDAGGIDPTVINGG----IINSYGSNAR 153

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH 226
           L D     V  + S  +    R+DG    + + TN+  +HLD++G  E    A     ++
Sbjct: 154 LGDSDWMVVEADESDGSFL--RLDGT---LAIVTNIDPEHLDHYGSFEKVQDAFVEFVSN 208

Query: 227 QDVQ-AAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVI 285
                AA + +D P    +L  +    RR+ ++      AD+ A  ++    G  F  VI
Sbjct: 209 VPFYGAAFLCIDHPVVQSILPRIRD--RRL-ITYGFSAQADIRAVDITPISGGNRFTAVI 265

Query: 286 GADHASVRS------PLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRL 339
                 +R       P+ GR N+ N L+  GV    +   + I    +    +  R +R+
Sbjct: 266 RGRDGDIRRIENIFLPMPGRHNIQNALSAIGVALEFSIPDAAIRDGFARFGGVKRRFSRV 325

Query: 340 GGQ---DGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVI- 395
           G     DG  +V+ DY H P  +  VLS+       R+I V     +  R  R    +  
Sbjct: 326 GEIKICDGSVLVIDDYGHHPVEIKAVLSAARESAQQRVIAVV----QPHRFLRLHDLMTE 381

Query: 396 ---AESNADVVFVTDDNPRGE------DGDGIVADILAGFARPNVVKVQRDRSAAIAAAI 446
              A ++AD+VFV      GE      D   +V+  L      +   V   RS AIA A 
Sbjct: 382 FQSAFNDADMVFVAPVYAAGEQPIAGVDSQALVSG-LKQHGHRSAQAVDSPRSLAIALA- 439

Query: 447 GIASAEDVVLIAGKG 461
            I  A+D+++  G G
Sbjct: 440 DIIKADDIIICVGAG 454


>gi|6460318|gb|AAF12038.1|AE002079_3 (AE002079)
           UDP-N-acetylmuramoylalanine--D-glutamiate ligase
           [Deinococcus radiodurans]
           Length = 457
           
 Score = 66.0 bits (158), Expect = 7e-10
 Identities = 67/225 (29%), Positives = 89/225 (38%), Gaps = 41/225 (18%)

Query: 104 MTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQC 163
           + MVG+TGT GK ST  L+AQ     G+R+   G +   L D V                
Sbjct: 119 LPMVGITGTAGKGSTTVLIAQLLRACGLRAREGGNIDPPLLDVV---------------- 162

Query: 164 LAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
                 + A+   +E+SS  L+  RV G+   V V TNL  DHLD HG +E Y AAK  +
Sbjct: 163 ------DDAEVAVVELSSFQLE--RVPGLRLPVAVITNLGVDHLDRHGSVETYHAAKLNI 214

Query: 224 FAHQDVQAAVINVDD-------------PFGLRLLHG---LAKGMRRVGVSVCGHTDADV 267
            A Q     ++   D             P  L L  G   L       GV       A +
Sbjct: 215 TAGQQSGDVLVRPADLPVPTRAQTVTFTPERLCLRDGQEVLPVADLPPGVHPANAAAALL 274

Query: 268 MAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVL 312
            A+ L  +L G   D  + AD      P+ GRF     L   G +
Sbjct: 275 AAEALLRHL-GRAVDPAVLADALRAAQPVKGRFETVGQLGEVGFI 318


>gi|2621606 (AE000836) UDP-N-acetylmuramyl tripeptide synthetase
           related protein [Methanobacterium thermoautotrophicum]
           Length = 404
           
 Score = 65.6 bits (157), Expect = 9e-10
 Identities = 61/210 (29%), Positives = 93/210 (44%), Gaps = 24/210 (11%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           V VTGTNGKT+T  ++A      G R    G  G G        G+T        + + +
Sbjct: 93  VAVTGTNGKTTTASMIAHVLESSGWRVLLGGNAGGGF------DGYT--------EVILR 138

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH 226
             +E    + +EV    L+    +    D+ V TNL  DHL++HG ME+Y  + A     
Sbjct: 139 AAEEEFDYIVVEVCDMTLEFAS-ECFDIDLAVITNLGEDHLNFHGSMENYRESVASFL-- 195

Query: 227 QDVQAAVINVDDPFGLRLLHGLAKGMRRV---GVSVCGHTDADVMAQHLSLNLQGIGFDL 283
            + +A VI+ D+P    L  G +  M      G  V       + A   +  L+ +G   
Sbjct: 196 -EGRAVVISADEPHLEELTSGASSVMEYTPYRGELVLEGEFNRLNAGAAAEALEFLGVPS 254

Query: 284 VIGADHASVRSPLMGR---FNVDNLLAVAG 310
            + + H SV  P+ GR   F+V++ L VAG
Sbjct: 255 EVISRHLSVFRPVAGRIRSFSVNDALVVAG 284


>gi|3122403|sp|O06222|MURD_MYCTU
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME)
           >gi|2104323|emb|CAB08672| (Z95388) murD [Mycobacterium
           tuberculosis]
           Length = 486
           
 Score = 64.0 bits (153), Expect = 3e-09
 Identities = 101/383 (26%), Positives = 148/383 (38%), Gaps = 69/383 (18%)

Query: 109 VTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLR 168
           VTGTNGKT+T  +L       G R+  CG +G  + D                     + 
Sbjct: 118 VTGTNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLD---------------------VL 156

Query: 169 DEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQD 228
           DE A+ +A+E+SS  L       +  +     N+  DHLD+H  M  Y AAKAR+     
Sbjct: 157 DEPAELLAVELSSFQLHW--APSLRPEAGAVLNIAEDHLDWHATMAEYTAAKARVLTG-- 212

Query: 229 VQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGAD 288
              AV  +DD     LL G +    RVG  +      ++  +   L  +    DL +   
Sbjct: 213 -GVAVAGLDDSRAAALLDG-SPAQVRVGFRLGEPAARELGVRDAHLVDRAFSDDLTL-LP 269

Query: 289 HASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVV 348
            AS+  P+ G   V + LA A +  ++      IA  +++ R    R   +   DG   V
Sbjct: 270 VASI--PVPGPVGVLDALAAAALARSVGVPAGAIADAVTSFRVGRHRAEVVAVADGITYV 327

Query: 349 VVDYAHTPDA--------------LGQVLSSLSSH-----VCGRLICVFGCGGERDRGKR 389
               A  P A               G +L   S H     +  RL+     G  RDR   
Sbjct: 328 DDSKATNPHAARASVLAYPRVVWIAGGLLKGASLHAEVAAMASRLVGAVLIG--RDRAAV 385

Query: 390 SQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRD-----------R 438
           ++       +  VV V      GED  G+ A +    A   V+ V +D            
Sbjct: 386 AEALSRHAPDVPVVQVV----AGED-TGMPATVEVPVA--CVLDVAKDDKAGETVGAAVM 438

Query: 439 SAAIAAAIGIASAEDVVLIAGKG 461
           +AA+AAA  +A   D VL+A  G
Sbjct: 439 TAAVAAARRMAQPGDTVLLAPAG 461


>gi|3393028|emb|CAA06440| (AJ005201) cyanophycin synthetase
           [Anabaena variabilis]
           Length = 901
           
 Score = 63.2 bits (151), Expect = 5e-09
 Identities = 100/394 (25%), Positives = 165/394 (41%), Gaps = 37/394 (9%)

Query: 90  GAMADR-FHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVV 148
           GA+ D  F    S  + ++ VTGTNGKT+T +LLA  +   G       T G  + D +V
Sbjct: 471 GAVMDMLFPNEQSGRIPILSVTGTNGKTTTTRLLAHIYKQTGKVVGYTTTDGTYIGDYLV 530

Query: 149 PTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLD 208
            +G  T            L+D   +   +E +   + +  +     +V V  N+  DHL 
Sbjct: 531 ESGDNT----GPQSAHVILQDPTVEVAVLETARGGILRSGLGFESANVGVVLNVAADHLG 586

Query: 209 YHGDMEHYG-AAKARLFAHQDVQA---AVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTD 264
             GD++     A  +    + V     AV+N DD    R +  +A+  +        + D
Sbjct: 587 I-GDIDTIDQLANLKSVVAESVYPDGYAVLNADD----RRVAAMAEKTKANIAYFTMNPD 641

Query: 265 ADVMAQHLSLN----LQGIGFDLVIGAD--HASVRS---PLM--GR--FNVDNLLAVAGV 311
           ++++ +H+       +   G+  ++  D  H   R+   PL   GR  F + N LA +  
Sbjct: 642 SELVRKHIQKGGVAAVYENGYLSIVKGDWTHRIERAEQIPLTMGGRAPFMIANALAASLA 701

Query: 312 LYALNYALSEIAAVLSTLR----PIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLS 367
            +  N ++ +I A L T R       GRMN      G    +VDYAH P +   V + + 
Sbjct: 702 AFVQNVSIEQIRAGLRTFRASVSQTPGRMNLF--NLGNYHALVDYAHNPASYEAVGAFVR 759

Query: 368 SHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFV-TDDNPRGEDGDGIVADILAGF 426
           +   G+ I V G  G+R       +  +A    D + V  DD+ RG       A I  G 
Sbjct: 760 NWTSGQRIGVVGGPGDRRDEDFVTLGKLAAEIFDYIIVKEDDDTRGRPRGSASALITKGI 819

Query: 427 --ARPNV-VKVQRDRSAAIAAAIGIASAEDVVLI 457
              +P+   +   D + AI   + +A A  +V+I
Sbjct: 820 TQVKPDARYESILDETQAINKGLDMAPANGLVVI 853


>gi|6225734|sp|Q9ZDS8|MURC_RICPR UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|3860809|emb|CAA14709| (AJ235271)
           UDP-N-ACETYLMURAMATE--ALANINE LIGASE (murC) [Rickettsia
           prowazekii]
           Length = 495
           
 Score = 62.1 bits (148), Expect = 1e-08
 Identities = 76/376 (20%), Positives = 164/376 (43%), Gaps = 49/376 (13%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           V V+G++GKT+T  L+A    CL   +  C T+  G    ++    T   +   +  +A+
Sbjct: 116 VAVSGSHGKTTTTSLIA----CLFEAAGLCPTVING---GIINNKSTNAYLGSSNYLIAE 168

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDME-HYGAAKARLFA 225
             +  A  + +  +               + + TN+  +HLDY+ D E   GA ++ +  
Sbjct: 169 ADESDATFIHIPST---------------IAIITNIDPEHLDYYQDFEILIGAFRSFITN 213

Query: 226 HQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVI 285
                 AV  +D     +L+  + +  R++        DA ++A +++ ++    FD+ I
Sbjct: 214 LPFYGFAVCCIDHKIVRKLVDDITE--RKIITYGIDSEDAHIIAFNINTDIASSTFDVKI 271

Query: 286 GADHA-------SVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNR 338
              +         +  P  GR N+ N LA   V   L++ +  I    +  + +  R  +
Sbjct: 272 SLPNVLGTTIIEKITIPTPGRHNILNSLAAIAVGIELDFGIKAIKNGFNNFKGVKRRFTK 331

Query: 339 LGGQDGQPVVVVDYAHTPDALGQVLS---SLSSHVCGRLICVFGCGGERDRGKRSQMA-- 393
           +  +  + V++ DYAH P+ +   L+   ++++   G++I +F    +  R  R +    
Sbjct: 332 V-AEYNKAVIIDDYAHHPEEIKATLATAKNIANQQNGKVIAIF----QPHRYSRIKYLFD 386

Query: 394 --VIAESNADVVFVTDDNPRGEDG-DGIVADILAGFARPNVVKVQRDRSAAIAAAIGI-- 448
             ++  ++AD++++T+    GE   +GI    L      N    + +  A +   + I  
Sbjct: 387 DFMLCFADADILYITNIYAAGETPIEGITGQSLVDKMTQNKHHDKANFLAELDDVVSIII 446

Query: 449 --ASAEDVVLIAGKGH 462
             A++ D++++ G G+
Sbjct: 447 DNAASGDMIIMMGAGN 462


>gi|2983375 (AE000709) UDP-MURNAC-pentapeptide sythetase [Aquifex
           aeolicus]
           Length = 445
           
 Score = 61.3 bits (146), Expect = 2e-08
 Identities = 81/344 (23%), Positives = 138/344 (39%), Gaps = 52/344 (15%)

Query: 4   SMPLAQLLP-DIPQARDVVISGLVMDSREVQPGDAFVAVAG--FGAHGLCFIEDACARGA 60
           S  LA++L   +  + ++ +    +DSR ++ G+ F+ + G  F AH   FI DA  +GA
Sbjct: 5   SQTLAKILKGSLVGSPNIPVKTFSIDSRTIKQGEVFIPLKGQKFDAHN--FIPDAFKKGA 62

Query: 61  VAILFEPPAPQGVSVPDGAIAV------HGLRARLGAMADRFHGHPSQAMTMVGVTGTNG 114
           V ++ E    + V VP G   +        LR       + F G       ++GV G+ G
Sbjct: 63  VGVISE----REVDVPPGKFLIKVRSTLESLREIAKFKRENFKGK------VIGVAGSAG 112

Query: 115 KTSTVQLLAQAWHCLGVRSATCGTLG--VGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGA 172
           KT+T +LL+      G    + G L   VGL   V      T   +  H         GA
Sbjct: 113 KTTTKELLSHLLSIKGKVYKSPGNLNSQVGLPLAVANASLETDFWVLEH---------GA 163

Query: 173 QAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAA 232
                  S     +  ++     V + T L  +HL+  G +E      A +F        
Sbjct: 164 -------SKRGEIKNLIEITKPHVRLITTLGEEHLEGFGSLEGVIWGNAEMFCR------ 210

Query: 233 VINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASV 292
              + D F   +       +  +   +      ++ AQ++ ++ +G+ F+  +  +   +
Sbjct: 211 ---ISDNFYAVIPGKFLDTLFFLPKKISFGERGELQAQNVEVSEKGVSFE--VEGEKFFI 265

Query: 293 RSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRM 336
             P +G   V+N+LA   VL  L + L E    L    P+ GRM
Sbjct: 266 SVPSLGL--VENILACFCVLKVLGFTLKEFKEALKEFSPVEGRM 307


>gi|1171075|sp|P45450|MURF_SYNY3
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME)
           >gi|1084179|pir||S49610
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate--D-alanyl-D-alanine ligase (EC
           6.3.2.15) - Synechocystis sp. (PCC 6803)
           >gi|575416|emb|CAA44303| (X62437)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate--D-alanyl-D-alanine ligase
           [Synechocystis sp.]
           Length = 454
           
 Score = 61.3 bits (146), Expect = 2e-08
 Identities = 88/358 (24%), Positives = 140/358 (38%), Gaps = 49/358 (13%)

Query: 17  ARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVS-- 74
           + D+ I+ +  D+R +  GD F+A+ G    G  FI  A   GA+A++ + P  +G+   
Sbjct: 25  SEDIRINNICTDTRSLVSGDLFLALRGESFDGHSFIPQALTAGAIAVVTDRPV-EGLGET 83

Query: 75  -----VPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCL 129
                V D  +A   + A       RF       + ++GVTG+ GKT+T +L+A      
Sbjct: 84  VAQFLVEDTLVAYQHIAA---GWRQRF------TIPIIGVTGSVGKTTTKELIAAVLSQF 134

Query: 130 GVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRV 189
           G    T        Y+  +    T   +L+L        D     V M +          
Sbjct: 135 GNVHKTRAN-----YNNEIGVPKT---LLELSP------DHDFAIVEMAMRGRGQIALLA 180

Query: 190 DGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQA-AVINVDDPFGLRLLHGL 248
           D     + + TN+   H+   G       AK  L AHQ  ++ A++N D+   +      
Sbjct: 181 DIAKPTIGLITNVGTAHIGLLGSELAIAEAKCELLAHQPPESTAILNRDNALLMETAQRF 240

Query: 249 AKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAV 308
            +G         G     V  ++L L             D  S+  PL G  N  N LA 
Sbjct: 241 WQGKTITYGLEGGDVHGTVDGENLIL-------------DGVSLPLPLAGVHNASNYLAA 287

Query: 309 AGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSL 366
             +   L     ++ + L+   P  GR  R   Q GQ VV++D  +  D L  +L+SL
Sbjct: 288 IALAQCLGLDWQQLQSGLTVELP-KGRARRY--QWGQDVVLLDETYN-DGLESMLASL 341


>gi|3024202|sp|P96613|MURF_BACSU
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME)
           >gi|1881267|dbj|BAA19294| (AB001488) PROBABLE
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2, 6-DIAMINOLIGASE
           (EC 6.3.2.15). [Bacillus subtilis]
           >gi|2632757|emb|CAB12264| (Z99106)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-
           diaminopimelate-D-alanyl-D-alanyl ligase [Bacillus
           subtilis]
           Length = 457
           
 Score = 60.9 bits (145), Expect = 2e-08
 Identities = 105/468 (22%), Positives = 178/468 (37%), Gaps = 54/468 (11%)

Query: 15  PQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVS 74
           PQ    VI G+  D+R+++    F+ + G    G  F+E A   G  A+L++   P    
Sbjct: 20  PQYEQTVIHGVATDTRKLEQHQLFIPLKGERFDGHSFVEQAFEAGVAAVLWDRSVPN--- 76

Query: 75  VPDGAIAVHGLRARLGAMADRFHGHPSQAMT-MVGVTGTNGKTSTVQLLAQAWHCLGVRS 133
            P    AV  +   L A+      +  +  T ++GVTG+NGKT+T  ++    H +    
Sbjct: 77  -PPENHAVILVDDTLTALQQLAKAYLQELGTRVIGVTGSNGKTTTKDMI----HAV---- 127

Query: 134 ATCGTLGVGLYDQVVPTG--FTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDG 191
                  +G   +V  TG  F   + L L         E  +   +E+   A  +G +D 
Sbjct: 128 -------LGTQYRVHKTGGNFNNHIGLPL---TVLAMPENTEIAVLEMGMSA--KGEIDL 175

Query: 192 V----HYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRLLHG 247
           +    + D  V TN+   H+   G  E    AK  +         +I + D   L+  + 
Sbjct: 176 LSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKEDGVLIYIGDEPLLQNAYS 235

Query: 248 LAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLA 307
                   G      T  D   Q +S + +G  F   I     +   P++G+ NV N +A
Sbjct: 236 CQTKTYGTG------THNDYQLQDVSQSEEGTHF--TIKGIENTFFIPILGKHNVMNAMA 287

Query: 308 VAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALG---QVLS 364
                     A  + A  LS L+    R+  +    G  ++   Y  +P ++    Q+  
Sbjct: 288 AIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNASPTSMKAAIQLTE 347

Query: 365 SLSSHVCGRLICVFG----CGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVA 420
           SL  +  G+ + V G     G   +   +   AVI+    D VF       G+ G  I  
Sbjct: 348 SLEGY--GKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFT-----YGKLGAFIAE 400

Query: 421 DILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEV 468
             L  F +   V    ++   + A    AS  D++L       + +E+
Sbjct: 401 GALKHFEKDR-VSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEI 447


>gi|3080475|emb|CAA18670.1| (AL022602) udp-n-acetylmuramoylalanine--
           d-glutamate ligase [Mycobacterium leprae]
           Length = 490
           
 Score = 60.1 bits (143), Expect = 4e-08
 Identities = 104/411 (25%), Positives = 158/411 (38%), Gaps = 70/411 (17%)

Query: 65  FEPPAPQGVSVPDGAIAVHG---LRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQL 121
           F P  P  V+     + + G   L  RL A    ++G P + +    VTGTNGKT+T  +
Sbjct: 80  FAPTTPVLVAASAARVPIWGDVELAWRLDAAG--YYGPPRRWLV---VTGTNGKTTTTSM 134

Query: 122 LAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSS 181
           L         RS  CG +G  + D  V T F  P                +  +A+E+SS
Sbjct: 135 LHAMLAADNRRSLLCGNIGRPVLD--VLTEFAEP----------------SDFLAVELSS 176

Query: 182 HALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFG 241
             L       +  +  V  N+  DHLD+H  M  Y  AKAR+      + AV+ +DD   
Sbjct: 177 FQLHW--APSLRPEAGVVLNIAEDHLDWHSTMADYTMAKARVLTG---RVAVVGLDDSRA 231

Query: 242 LRLLHGLAKGMR---RVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASV---RSP 295
             LL      +R   R G    G                G   D     D A +     P
Sbjct: 232 AALLSTTVAPVRVGFRFGEPAVGELGV----------RDGYLVDRAFAEDLALMPVTSIP 281

Query: 296 LMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVD---Y 352
           + G   V + LA A +  ++    + IA  ++        + RLG    + V V D   Y
Sbjct: 282 VSGPVGVLDALAAAALARSVGVGATAIADAVA--------LFRLGRHRAEVVAVADGIRY 333

Query: 353 AHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRG 412
                A     + +S     R++ V G G  +     +++A +A      V +  D    
Sbjct: 334 VDDSKATNPHAALVSVLAYPRVVWVAG-GLLKGASVDAEVARMAPQLVGAVLIGRDR--- 389

Query: 413 EDGDGIVADILAGFARPN--VVKVQRDRSAAIAAAIGIASAEDVVLIAGKG 461
                +VA+ L+  A PN  VV+V     A +  A+ + S  DV+ I+  G
Sbjct: 390 ----AMVAEALSRHA-PNVPVVQVVAGEDAGM-HAVAVVSGTDVISISDVG 434


>gi|3080477|emb|CAA18672.1| (AL022602)
           udp-n-acetylmuramoylalanyl-d-glutamyl
           -2,6-diaminopimelate--d-alanyl-d-alanyl ligase
           [Mycobacterium leprae]
           Length = 517
           
 Score = 59.7 bits (142), Expect = 5e-08
 Identities = 96/378 (25%), Positives = 140/378 (36%), Gaps = 48/378 (12%)

Query: 21  VISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPP--APQGVSVPDG 78
           V   +  DSR V PG  F+A+ G  + G      A A GAVA+L   P   P  V  PD 
Sbjct: 30  VTGSVEFDSRAVGPGGLFLALPGARSDGHDHAASAIAAGAVAVLAARPVGVPAIVVAPDP 89

Query: 79  AIAVHGL------------RARLGAMADRFHGHPSQ----AMTMVGVTGTNGKTSTVQLL 122
                GL             A L A+A       ++     +T++G+TG++GKTST  L+
Sbjct: 90  RTGDGGLTGVLEHDADGSGAAVLAALAKLAKAVAAELVAGGLTIIGITGSSGKTSTKDLV 149

Query: 123 AQAWHCLGVRSATCGTLGVGL---YDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEV 179
           A     LG   A   +    L   +  +  T  T  L+L++       R  G  A    +
Sbjct: 150 AVVLELLGEVVAPPESFNNELGHPWTVLRATRSTDYLILEM-----SARRPGNIAALAAI 204

Query: 180 SSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL-FAHQDVQAAVINVDD 238
           +   +             V  N+   HL   G  E     K  L  A       ++NVDD
Sbjct: 205 APPKIG------------VVLNVGTAHLGEFGSREAIARTKTELPQAIMQSGVVILNVDD 252

Query: 239 PFGLRLLHGLAKGMRRVGVSVCGH----TDADVMAQHLSLN-LQGIGFDLVI---GADHA 290
           P    +       + RV      H       DV    +SL+ L    F L      A   
Sbjct: 253 PAVAAMADATVARVIRVSRGSYSHPGSPNSPDVWTGPVSLDELARPRFTLHTRDPRAGAT 312

Query: 291 SVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPI-HGRMNRLGGQDGQPVVV 349
            ++  + G   V N L  A V      ++ E+A  L+   P+   RM      DG  V+ 
Sbjct: 313 EIQLGVYGDHQVANALCAAAVGLECGASVEEVAVALAATGPVSRHRMQVTTRADGVTVID 372

Query: 350 VDYAHTPDALGQVLSSLS 367
             Y   PD++   L +L+
Sbjct: 373 DTYNANPDSMRAGLQALA 390


>gi|1653256|dbj|BAA18171| (D90912)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate-D-alanyl-D-alanine ligase
           [Synechocystis sp.]
           Length = 454
           
 Score = 59.7 bits (142), Expect = 5e-08
 Identities = 88/358 (24%), Positives = 139/358 (38%), Gaps = 49/358 (13%)

Query: 17  ARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVS-- 74
           + D+ I+ +  D+R +  GD F+A+ G    G  FI  A   GA+A++ + P  +G+   
Sbjct: 25  SEDIRINNICTDTRSLVSGDLFLALRGESFDGHSFIPQALTAGAIAVVTDRPV-EGLGET 83

Query: 75  -----VPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCL 129
                V D  +A   + A       RF       + ++GVTG+ GKT+T +L+A      
Sbjct: 84  VAQFLVEDTLVAYQHIAA---GWRQRF------TIPIIGVTGSVGKTTTKELIAAVLSQF 134

Query: 130 GVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRV 189
           G    T        Y+  +    T   +L+L        D     V M +          
Sbjct: 135 GNVHKTRAN-----YNNEIGVPKT---LLELSP------DHDFAIVEMAMRGRGQIALLA 180

Query: 190 DGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQA-AVINVDDPFGLRLLHGL 248
           D     + + TN+   H+   G       AK  L AHQ  ++ A++N D+   +      
Sbjct: 181 DIAKPTIGLITNVGTAHIGLLGSELAIAEAKCELLAHQPPESTAILNRDNALLMETAQRF 240

Query: 249 AKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAV 308
            +G         G     V  ++L L             D  S+  PL G  N  N LA 
Sbjct: 241 WQGKTITYGLEGGDVHGTVDGENLIL-------------DGVSLPLPLAGVHNASNYLAA 287

Query: 309 AGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSL 366
             V   L     ++ + L+   P  GR  R   Q GQ VV++D  +    L  +L+SL
Sbjct: 288 IAVAQCLGLDWQQLQSGLTVELP-KGRARRY--QWGQDVVLLDETYNA-GLESMLASL 341


>gi|3122410|sp|P73668|MURD_SYNY3
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME)
           >gi|1652794|dbj|BAA17713| (D90908)
           UDP-N-acetylmuramoylalanine-D-glutamate ligase
           [Synechocystis sp.]
           Length = 452
           
 Score = 59.3 bits (141), Expect = 7e-08
 Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 23/137 (16%)

Query: 103 AMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQ 162
           A+  VG+TGTNGKT+T  L+   +   G+ +  CG +G                      
Sbjct: 105 AVPWVGITGTNGKTTTTSLVQAIFQKAGLNAPACGNIGYA-------------------A 145

Query: 163 CLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKAR 222
           C   L+++    +  E+SS+ ++      +   + ++T  T DHL  H  +E+Y   KA 
Sbjct: 146 CELVLQNQNYDWIVAEISSYQIESSPT--LAPQIGLWTTFTPDHLSRHKTLENYFNIKAS 203

Query: 223 LFAHQDVQAAVINVDDP 239
           L +   +Q  V+N DDP
Sbjct: 204 LLSRSAIQ--VLNGDDP 218


>gi|1652973|dbj|BAA17890| (D90910) hypothetical protein
           [Synechocystis sp.]
           Length = 873
           
 Score = 58.9 bits (140), Expect = 9e-08
 Identities = 94/401 (23%), Positives = 154/401 (37%), Gaps = 36/401 (8%)

Query: 98  GHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLV 157
           G PS+ + ++ VTGTNGKT+T +LLA  +   G       T  + + +  V  G  T   
Sbjct: 483 GTPSR-IPILAVTGTNGKTTTTRLLAHIYRQTGKTVGYTSTDAIYINEYCVEKGDNT--- 538

Query: 158 LQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGD---ME 214
                    LRD   +   +E +   + +  +     DV V  N+  DHL   GD   +E
Sbjct: 539 -GPQSAAVILRDPTVEVAVLETARGGILRAGLAFDTCDVGVVLNVAADHLGL-GDIDTIE 596

Query: 215 HYGAAKARLFAHQDVQA-AVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLS 273
                K+ +    D    AV+N DDP    L+  +A  ++        + D  V+  H+ 
Sbjct: 597 QMAKVKSVIAEVVDPSGYAVLNADDP----LVAAMADKVKAKVAYFSMNPDNPVIQNHIR 652

Query: 274 LN-------------LQGIGFDLVIGADHASVRSPLMGRFNVDNLLA--VAGVLYALNYA 318
            N             L+G     V  A    +    M  F + N LA  +A  +  L+  
Sbjct: 653 RNGIAAVYESGYVSILEGSWTLRVEEATLIPMTMGGMAPFMIANALAACLAAFVNGLDVE 712

Query: 319 L--SEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLIC 376
           +    +    ++     GRMN      G+   +VDYAH P     V   + +    R   
Sbjct: 713 VIRQGVRTFTTSAEQTPGRMNLF--NLGRYHALVDYAHNPAGYRAVGDFVKNWHGQRFGV 770

Query: 377 VFGCGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPN---VVK 433
           V G G  RD        + A+    ++   DD+ RG  G      I+ G  + N     +
Sbjct: 771 VGGPGDRRDSDLIELGQIAAQVFDRIIVKEDDDKRGRSGGETADLIVKGILQENPGAAYE 830

Query: 434 VQRDRSAAIAAAIGIASAEDVVLIAGKGHERYQEVAGVRHP 474
           V  D + A+  A+     + +V++  +   +  E+   R P
Sbjct: 831 VILDETVALNKALDQVEEKGLVVVFPESVSKAIELIKARKP 871


>gi|4980734|gb|AAD35327.1|AE001707_14 (AE001707)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate--D-alanyl-D-alanyl ligase [Thermotoga
           maritima]
           Length = 426
           
 Score = 58.2 bits (138), Expect = 2e-07
 Identities = 64/223 (28%), Positives = 95/223 (41%), Gaps = 21/223 (9%)

Query: 18  RDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPD 77
           +D++    V++S+EV+ GD FVAV G    G  FI++A   GA AI+ E          D
Sbjct: 2   KDLLTRRFVLNSKEVREGDVFVAVKGKRFDGHDFIDEALRNGAYAIIAERKTVNS----D 57

Query: 78  GAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCG 137
               V      L  +A    G+ S   T+VGVTG++GKT+T ++L   ++ L  + +   
Sbjct: 58  RIFLVESSVDTLAKLAREKLGNFSG--TVVGVTGSSGKTTTKEIL---YNLLKNKRSVFK 112

Query: 138 TLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVV 197
           T G       + T +  PL +     L   + E    + M  S              DV 
Sbjct: 113 TPG------NMNTEYGLPLSI-----LNDYKGEEILVLEMAASRPGDIAHLCKIAPPDVA 161

Query: 198 VFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQA-AVINVDDP 239
           V  N+   HL++ G  E     K  +  H    A AV   DDP
Sbjct: 162 VLLNVGSAHLEFFGTRERIMETKMEIIKHSKENAIAVTLFDDP 204


>gi|5834372|gb|AAD53938.1|AF179611_22 (AF179611)
           UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
           [Zymomonas mobilis]
           Length = 269
           
 Score = 58.2 bits (138), Expect = 2e-07
 Identities = 49/151 (32%), Positives = 66/151 (43%), Gaps = 23/151 (15%)

Query: 89  LGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVV 148
           L A A  F     +   +VG+TGTNGK++T  L+       G+ +   G +G+ L     
Sbjct: 107 LFAQAHGFWERHGRRCPVVGITGTNGKSTTTALIHHILKEAGLPTLMGGNIGLPLL---- 162

Query: 149 PTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLD 208
                             L D G     +E+SS+ +D      +  D+ V TN+T DHLD
Sbjct: 163 --------------AADPLPDGGVYV--LELSSYQIDLTFT--LDCDIAVLTNITPDHLD 204

Query: 209 YHGDMEHYGAAKARLFAHQ-DVQAAVINVDD 238
            HG  E Y  AK RLF  Q     AVI  DD
Sbjct: 205 RHGGFEGYRKAKERLFLLQSSPHYAVIATDD 235


>gi|6093445|sp|O83873|MURD_TREPA
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|3323217 (AE001259)
           UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
           [Treponema pallidum]
           Length = 532
           
 Score = 57.0 bits (135), Expect = 4e-07
 Identities = 42/140 (30%), Positives = 68/140 (48%), Gaps = 11/140 (7%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQC-L 164
           ++ V+G+ GK+ST   L  +   LG  +   G   V   + V  T   TP+VL+L    L
Sbjct: 119 LLAVSGSKGKSSTASALCYSLRALGFPAFLGGNSTVSPLEFVRHTTPATPVVLELSSWQL 178

Query: 165 AQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLF 224
           A LR       A++   H +    +  +  ++ + T +  DH +++ DME Y A K  L+
Sbjct: 179 ADLR-------AVDAQDHTVHHAGL--LRPEIAIMTPIMADHQNWYADMESYVADKQVLY 229

Query: 225 AHQDVQAAVI-NVDDPFGLR 243
           AHQ     ++ N DD +G R
Sbjct: 230 AHQGTHDTLLCNADDGWGPR 249


>gi|5834374|gb|AAD53940.1|AF179611_24 (AF179611)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate-D-alanyl-D-alanyl ligase [Zymomonas
           mobilis]
           Length = 463
           
 Score = 56.2 bits (133), Expect = 6e-07
 Identities = 87/357 (24%), Positives = 142/357 (39%), Gaps = 30/357 (8%)

Query: 19  DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAP-QGVSVPD 77
           D  +  +  DSRE+Q GD F A+ G  + G  ++E A  RGA   +   P P   + V D
Sbjct: 21  DFSVRNVAFDSREIQKGDLFFALKGTESDGHNYVEAAFKRGAAGAVVMSPVPYPHILVDD 80

Query: 78  GAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCG 137
              A+  L     A+A R   H      ++G+TG+ GKTST + L  A   +        
Sbjct: 81  SYQALKDL-----AVASRKRNHGK----IIGITGSVGKTSTKESLRLALERMAPEKV--- 128

Query: 138 TLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDG-VHYDV 196
              +  Y+  V      PL       LA++ +E    +     +HA +   +   V  DV
Sbjct: 129 HYSLKSYNNHV----GVPL------SLARMPEESLFGIFEMGMNHAGELSDLTKLVQPDV 178

Query: 197 VVFTNLTRDHLDYHGDMEHYGAAKARLF-AHQDVQAAVINVDDPFGLRLLHGLAKGMRRV 255
            + T +   H  +  D      AK+ +F        A+I  D P+   LL   A+  +  
Sbjct: 179 ALITAIAPAHAAFFADETAIAEAKSEIFEGLSSGGIAIIPHDSPY-RDLLTAKAQEKKAE 237

Query: 256 GVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFN-VDNLLAVAGVLYA 314
             S      A + AQ++     G         D   V S  M   + + N +AV  V+ A
Sbjct: 238 IRSFGFGEGATIRAQNIVREADGRVLVTASIRDRQLVFSMAMAAEHWISNAMAVLAVVDA 297

Query: 315 LNYALSEIAAVLSTLRPIHGRMNR--LGGQDGQPVVVVD-YAHTPDALGQVLSSLSS 368
           +   L+  +  L  +    GR  R  +   DG  +V+ + Y   P ++   + +L +
Sbjct: 298 VGGDLTLASLALGDITGFQGRGQRFDIPVGDGSAIVIDESYNANPASMAATIKALEN 354


>gi|3122408|sp|O31211|MURC_STAAU UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|2642659|gb|AAB87090.1| (AF034076)
           UDP-N-acetylmuramoyl-L-alanine synthetase
           [Staphylococcus aureus]
           Length = 437
           
 Score = 56.2 bits (133), Expect = 6e-07
 Identities = 72/272 (26%), Positives = 103/272 (37%), Gaps = 40/272 (14%)

Query: 96  FHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTP 155
           F G      T V VTG +GKTST  LL+   H +     T   +G G       TG   P
Sbjct: 93  FLGQIIDQYTSVAVTGAHGKTSTTGLLS---HVMNGDKKTSFLIGDG-------TGMGLP 142

Query: 156 LVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEH 215
                         +     A E   H L          D  + TN+  DH DY  D+  
Sbjct: 143 ------------ESDYFAFEACEYRRHFLSYKP------DYAIMTNIDFDHPDYFKDIND 184

Query: 216 YGAAKARLFAHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDAD-VMAQHLSL 274
              A   + AH +V+  +I   D   LR +         V +   G  D+D + AQ++ +
Sbjct: 185 VFDAFQEM-AH-NVKKGIIAWGDDEHLRKIEA------DVPIYYYGFKDSDDIYAQNIQI 236

Query: 275 NLQGIGFDLVI-GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIH 333
             +G  FD+ + G  +    SP  G   V N LAV  + Y     ++ I   L T   + 
Sbjct: 237 TDKGTAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVK 296

Query: 334 GRMNRLGGQDGQPVVVVDYAHTPDALGQVLSS 365
            R N         V+V DYAH P  +   + +
Sbjct: 297 RRFNET--TIANQVIVDDYAHHPREISATIET 326


>gi|6093451|sp|O83401|MURF_TREPA
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME) >gi|3322664
           (AE001217)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate--D-alanyl-D-alanine ligase (murF)
           [Treponema pallidum]
           Length = 459
           
 Score = 54.7 bits (129), Expect = 2e-06
 Identities = 85/364 (23%), Positives = 137/364 (37%), Gaps = 44/364 (12%)

Query: 24  GLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQG-------VSVP 76
           G+  DSR V P D F+ + G    G  F+E+A  +GAVA L +   P             
Sbjct: 28  GVSFDSRAVVPRDLFIPLRGAHVDGHTFVEEALQKGAVATLIDQRYPHAGEYVAWCTRFG 87

Query: 77  DGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATC 136
              IAVH     L  +A  F+     A+  +G+TG++GKT TV+ +A+A      R    
Sbjct: 88  AACIAVHDTLRALQDLAS-FYCKKFPALIRIGITGSSGKT-TVKEMARAVFSERYR---- 141

Query: 137 GTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDE---GAQAVAMEVSSHALDQGRVDGVH 193
                     VV T       + L Q L  +R E   G   + M          ++   H
Sbjct: 142 ----------VVATPGNLNSEIGLPQSLFFVRAEHEVGIFELGMNRRGEMRTLAQILVPH 191

Query: 194 YDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRLLHGLAKGMR 253
           Y ++  TN+   H+   G  +     K  +F+     +     DD + +  L  +  G  
Sbjct: 192 YAII--TNVGCAHVGILGTQQAIAEEKKEIFSQFTEHSVGFVPDDAYRV-FLSNIPYGR- 247

Query: 254 RVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLY 313
              V V       +  + +   L+G      +      +R PL G  N  N LAV  +  
Sbjct: 248 ---VVVYDQGGRGLATEVIDEGLRGSR----VLYQGRWIRVPLPGVHNAKNALAVIALAA 300

Query: 314 ALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGR 373
            +     EI   +  ++P  GR + +        ++  Y   PD++   L     H+C  
Sbjct: 301 QVGLPAEEIQRGMERVKPPFGRSHVVCA--SLTFLLDCYNANPDSMAAAL-----HLCAH 353

Query: 374 LICV 377
           +  V
Sbjct: 354 ISAV 357


>gi|6919927|sp|O67373|MURC_AQUAE UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|2983764 (AE000736) UDP-N-acetylmuramate-alanine
           ligase [Aquifex aeolicus]
           Length = 454
           
 Score = 54.7 bits (129), Expect = 2e-06
 Identities = 87/367 (23%), Positives = 143/367 (38%), Gaps = 50/367 (13%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           + V+G++GKT+T  ++A+              +  GL   V+  G              +
Sbjct: 109 IAVSGSHGKTTTTSMIAEI------------LINAGLEPTVIIGG--------------R 142

Query: 167 LRDEGAQAVA----MEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKAR 222
           L+  G  A      + VS      G    +   V V TN+ ++HLD++ + E    A  +
Sbjct: 143 LKRLGTNAKLGRGELLVSEADESDGSFLKLQPAVAVITNVDKEHLDFYENFERVKEAFEQ 202

Query: 223 LFAHQDVQA-AVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGF 281
                     AV+N+DDP   +L+    + +   G+    ++ A V A++L L      F
Sbjct: 203 FMNSVPFYGFAVVNLDDPTLAQLVKKSHERVITYGI----NSPALVRAKNLYLKEGRYEF 258

Query: 282 DLVI-GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLG 340
            +   G +   +   + G  NV N LA  GV   L  +   I   L   R    R+   G
Sbjct: 259 GVEFKGKELGRIHLGIAGIHNVYNALAATGVALELGVSFEVIKKSLEEFRNAERRLELKG 318

Query: 341 GQDGQPVVVVDYAHTPDALGQVLSSL-SSHVCGRLICVFGCGGERDRGKRS----QMAVI 395
                P V  DY H P  +  V++SL   +    L+ VF    +  R  R+    +  V 
Sbjct: 319 YYKNSP-VYDDYGHHPTEIKAVINSLRDMYPDKNLLVVF----QPHRYSRTYYLFEDFVK 373

Query: 396 AESNADVVFVTDDNPRGEDG-DGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDV 454
              + D + VTD  P  E+   G+ A+ L   AR +     +D+         +    DV
Sbjct: 374 VLKDIDKLIVTDIYPASENNVYGVSAEEL---ARKSGAVFAKDKEEVFEKVREVHDEGDV 430

Query: 455 VLIAGKG 461
           +L  G G
Sbjct: 431 ILFLGAG 437


>gi|6458474|gb|AAF10342.1|AE001931_13 (AE001931)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,
           6-diaminopimelate--D-alanyl-D-alanyl ligase [Deinococcus
           radiodurans]
           Length = 433
           
 Score = 54.3 bits (128), Expect = 2e-06
 Identities = 43/123 (34%), Positives = 57/123 (45%), Gaps = 14/123 (11%)

Query: 3   RSMPLAQLLPDIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVA 62
           RS+P A  +   PQAR      L  DSRE  P  AFVA+ G   HG  F+E A A GA  
Sbjct: 5   RSVPFAAQIH--PQARPA--RRLTWDSREAGPDTAFVALPGEKMHGNRFVERALAAGAPF 60

Query: 63  ILFEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLL 122
           +L +   P+ V V D            GA+        ++   +VG+TG+ GKT+     
Sbjct: 61  VLTDLDVPRAVRVDDAR----------GALFAWARSERAKNPLVVGITGSAGKTTAKSYA 110

Query: 123 AQA 125
           A A
Sbjct: 111 AAA 113


>gi|3090871 (AF035938) uridine diphosphate
           N-acetylmuramoyl-L-alanine:D-glutamate ligase
           [Streptococcus pyogenes]
           Length = 452
           
 Score = 53.9 bits (127), Expect = 3e-06
 Identities = 60/236 (25%), Positives = 92/236 (38%), Gaps = 32/236 (13%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           ++G+TG+NGKT+T  ++A   +  G  +   G +G              P    + + +A
Sbjct: 114 IIGITGSNGKTTTTTMIADVLNAGGQSALLSGNIGY-------------PASKVVQKAIA 160

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFA 225
                    + ME+SS  L    V+     + V TNL   HLDYHG  E Y AAK  + A
Sbjct: 161 ------GDTLVMELSSFQLVG--VNAFRPHIAVITNLMPTHLDYHGSFEDYVAAKWMIQA 212

Query: 226 HQ-DVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLV 284
              +    ++N +          LAK  +   +     T   V   +L   +       +
Sbjct: 213 QMTESDYLILNANQEISAT----LAKTTQATVIPF--STQKVVDGAYLKDGILYFKEQAI 266

Query: 285 IGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLG 340
           I A    V     G  N++N LA   V      A   IA  LS    +  R+ R+G
Sbjct: 267 IAATDLGV----PGSHNIENALATIAVAKLSGIADDIIAQCLSHFGGVKHRLQRVG 318


>gi|1171072|sp|P45063|MURD_HAEIN
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|1075422|pir||B64185
           UDP-N-acetylmuramoylalanine-D-glutamate ligase (murD)
           homolog - Haemophilus influenzae (strain Rd KW20)
           >gi|1574691 (U32793)
           UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
           [Haemophilus influenzae Rd]
           Length = 437
           
 Score = 53.1 bits (125), Expect = 5e-06
 Identities = 51/239 (21%), Positives = 97/239 (40%), Gaps = 33/239 (13%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +VG+TG+NGK++   L+ +     GV+    G +G+                        
Sbjct: 107 IVGITGSNGKSTVTTLVYEMAKAAGVKVGMGGNIGIP---------------------AL 145

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFA 225
            L +E  +   +E+SS  L+      +        N+T DH+D + D+E Y  AK R++ 
Sbjct: 146 SLLNEDCELYVLELSSFQLE--TTYSLKAAAATVLNVTEDHMDRYMDLEDYRQAKLRIY- 202

Query: 226 HQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVI 285
             + +  V+N +D    RL  G  +   +  VS   ++    +          +  ++++
Sbjct: 203 -HNAKVGVLNNED----RLTFGENENQAKHTVSFAENSADYWLKTENGKQYLMVKDEVIL 257

Query: 286 GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDG 344
             + A+    L+GR N  N+LA   +  A+   L  I   L   + +  R   +   +G
Sbjct: 258 PCEEAT----LVGRHNYMNILAATALAQAIGINLDSIRTALRHFKGLDHRFQLVHQANG 312


>gi|4377219|gb|AAD19037| (AE001670) Muramoyl-DAP Ligase [Chlamydia
           pneumoniae]
           Length = 447
           
 Score = 53.1 bits (125), Expect = 5e-06
 Identities = 60/231 (25%), Positives = 95/231 (40%), Gaps = 28/231 (12%)

Query: 19  DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDG 78
           D  I+G  +DS++VQPGD F A+ G    G  F++ A   GAVA +      QG S    
Sbjct: 23  DKKITGFAIDSQQVQPGDLFFALPGNATDGHQFLKHAATAGAVAAVVSHDY-QGDSFGLE 81

Query: 79  AIAVHGLRARL----GAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSA 134
            I V   ++ L        + F G      T+VG+TG+ GKT+T +              
Sbjct: 82  LIRVDDTKSALQEAGSNQCNLFQG------TLVGITGSVGKTTTKEF------------- 122

Query: 135 TCGTLGVGLY-DQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVH 193
              T+   +Y     P  + + L + L   +A+  DE    + M VS     Q  +  V 
Sbjct: 123 -SKTILSSIYKTHASPKSYNSQLTVPLSLLMAE-GDEDVMILEMGVSEPGNMQDLLRIVQ 180

Query: 194 YDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRL 244
            ++ V T++   H   H         K + +  Q  +  ++  D P+ L L
Sbjct: 181 PEIAVITHINDQHA-MHFPQGIQEILKEKSYILQKSKLQLLPKDSPYYLDL 230


>gi|417327|sp|Q03522|MURD_BACSU
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|478078|pir||D47691
           UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC
           6.3.2.9) - Bacillus subtilis >gi|580932|emb|CAA78769|
           (Z15056) murD [Bacillus subtilis]
           >gi|2633891|emb|CAB13393| (Z99111)
           UDP-N-acetylmuramoylalanine D-glutamate ligase [Bacillus
           subtilis]
           Length = 451
           
 Score = 51.9 bits (122), Expect = 1e-05
 Identities = 56/244 (22%), Positives = 99/244 (39%), Gaps = 39/244 (15%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           +G+TG+NGKT+T  L+ +       ++   G +G            T    +  H     
Sbjct: 116 IGITGSNGKTTTTTLIYEMLKADSQKALIAGNIG------------TVASEVAYHA---- 159

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHY---DVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
              +G + +  E+SS  L      G H    ++ +  N+   HLDYH   E+Y  AK ++
Sbjct: 160 ---DGDEWIVTELSSFQLM-----GTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKV 211

Query: 224 FAHQDV-QAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGI-GF 281
           + HQ     A++N DD   +RL       +    VS      A V    +  N + I   
Sbjct: 212 YLHQTASDKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPL 271

Query: 282 DLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGG 341
           + V+          L G  N++N+LA   V+     +   +  VL++   +  R+  +  
Sbjct: 272 EEVV----------LPGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTT 321

Query: 342 QDGQ 345
            +G+
Sbjct: 322 VNGR 325


>gi|39993|emb|CAA45555| (X64258)
           UDP-N-acetylmuramoylalanine--D-glutamate ligase
           [Bacillus subtilis] >gi|383709|prf||1904153A murD gene
           [Bacillus subtilis]
           Length = 369
           
 Score = 51.9 bits (122), Expect = 1e-05
 Identities = 56/244 (22%), Positives = 99/244 (39%), Gaps = 39/244 (15%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           +G+TG+NGKT+T  L+ +       ++   G +G            T    +  H     
Sbjct: 34  IGITGSNGKTTTTTLIYEMLKADSQKALIAGNIG------------TVASEVAYHA---- 77

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHY---DVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
              +G + +  E+SS  L      G H    ++ +  N+   HLDYH   E+Y  AK ++
Sbjct: 78  ---DGDEWIVTELSSFQLM-----GTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKV 129

Query: 224 FAHQDV-QAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGI-GF 281
           + HQ     A++N DD   +RL       +    VS      A V    +  N + I   
Sbjct: 130 YLHQTASDKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPL 189

Query: 282 DLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGG 341
           + V+          L G  N++N+LA   V+     +   +  VL++   +  R+  +  
Sbjct: 190 EEVV----------LPGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTT 239

Query: 342 QDGQ 345
            +G+
Sbjct: 240 VNGR 243


>gi|3122404|sp|O06225|MURC_MYCTU UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|2104326|emb|CAB08641| (Z95388) murC [Mycobacterium
           tuberculosis]
           Length = 494
           
 Score = 50.8 bits (119), Expect = 3e-05
 Identities = 103/396 (26%), Positives = 152/396 (38%), Gaps = 85/396 (21%)

Query: 105 TMVGVTGTNGKTSTVQLLAQAW-HC-LGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQ 162
           T + VTGT+GKT+T  +L  A  HC L    A  G LG    +    +G           
Sbjct: 116 TTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSG----------D 165

Query: 163 CLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKAR 222
           C     DE   ++ ++ + H             V V TN+  DHLD++G +E Y  A   
Sbjct: 166 CFVAEADESDGSL-LQYTPH-------------VAVITNIESDHLDFYGSVEAY-VAVFD 210

Query: 223 LFAHQDVQ--AAVINVDDPFGLRLLHGLAKGMRRVGVSVC--GHTDADVMAQHL-SLNLQ 277
            F  + V   A V+  DDP G      LA+    +G+ V   G    + MA  L S   Q
Sbjct: 211 SFVERIVPGGALVVCTDDPGGA----ALAQRATELGIRVLRYGSVPGETMAATLVSWQQQ 266

Query: 278 GIG--FDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGR 335
           G+G    + + ++ A+ + P + R      L+V G   ALN AL  + A +    P    
Sbjct: 267 GVGAVAHIRLASELATAQGPRVMR------LSVPGRHMALN-ALGALLAAVQIGAPADEV 319

Query: 336 MNRLGGQDG----------------QPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFG 379
           ++ L G +G                   V  DYAH P  +   L++       R++   G
Sbjct: 320 LDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAA------ARMVLEQG 373

Query: 380 CGG-----------ERDRGKRSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFAR 428
            GG            R +   ++    A + AD VFV D     E     +A +      
Sbjct: 374 DGGRCMVVFQPHLYSRTKAFAAEFG-RALNAADEVFVLDVYGAREQP---LAGVSGASVA 429

Query: 429 PNVVKVQR---DRSAAIAAAIGIASAEDVVLIAGKG 461
            +V    R   D SA        AS  DV++  G G
Sbjct: 430 EHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAG 465


>gi|4009480 (AF068902) D-glutamic acid adding enzyme MurD
           [Streptococcus pneumoniae]
           Length = 450
           
 Score = 50.4 bits (118), Expect = 3e-05
 Identities = 82/361 (22%), Positives = 132/361 (35%), Gaps = 66/361 (18%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           ++G+TG+NGKT+T  ++ +     G      G +G                       +A
Sbjct: 114 IIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQ------------------VA 155

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFA 225
           Q+  +    + ME+SS  L    V   H ++ V TNL   H+DYHG  E Y AAK  +  
Sbjct: 156 QIATD-KNTLVMELSSFQLMG--VQEFHPEIAVITNLMPTHIDYHGLFEEYVAAKWNI-- 210

Query: 226 HQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDAD-VMAQHLSLNLQGIGFDLV 284
            Q+   A   +   F   L+  LA       V        D    +   L  +G   ++V
Sbjct: 211 -QNKMTAADFLVLNFNQDLVKDLASKTEATVVPFSTLEKVDGAYLEDGQLYFRG---EVV 266

Query: 285 IGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDG 344
           + A+   V     G  NV+N LA   V          I   LS    +  R+  +    G
Sbjct: 267 MAANEIGV----PGSHNVENALATIAVAKLRGVDNQTIKETLSAFGGVKHRLQFVDDIKG 322

Query: 345 QPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVVF 404
                V + +          S S+++                   +Q A+    N+ VV 
Sbjct: 323 -----VKFYN---------DSKSTNILA-----------------TQKALSGFDNSKVVL 351

Query: 405 VTDDNPRGEDGDGIVADILAGFARPNVV--KVQRDRSAAIAAAIGIASAEDVVLIAGKGH 462
           +     RG + D +V DI  G  +  ++    +R + AA  A +    A D+     K +
Sbjct: 352 IAGGLDRGNEFDELVPDI-TGLKKMVILGQSAERVKRAADKAGVAYVEATDIADATRKAY 410

Query: 463 E 463
           E
Sbjct: 411 E 411


>gi|6458326|gb|AAF10205.1|AE001920_8 (AE001920)
           UDP-N-acetylmuramate--alanine ligase [Deinococcus
           radiodurans]
           Length = 482
           
 Score = 50.0 bits (117), Expect = 5e-05
 Identities = 100/403 (24%), Positives = 151/403 (36%), Gaps = 59/403 (14%)

Query: 85  LRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLY 144
           +R R+  + +     PS     VGV GT+GKT+T  ++A A +  G+  +      V  +
Sbjct: 119 VRPRMALLGELLAAGPS-----VGVIGTHGKTTTTSMIAVAMYGAGLDPSAFVGGNVPEF 173

Query: 145 DQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTR 204
                TG T P V ++        DE  +  A+              +  +  VFTN   
Sbjct: 174 GGNARTG-TGPFVAEV--------DESDRGFAL--------------LGCETAVFTNAED 210

Query: 205 DHL-----DYHGDMEHYGAAKARLFAHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSV 259
           DH+      Y   +E   A  AR  A       V+   D  GL  L   A+     G S 
Sbjct: 211 DHVGGELATYWSTVEEQHAGFARFVAQ---SGRVLFCADWPGLDTLCSGAREQLTYGQS- 266

Query: 260 CGHTDADVMAQHLSLNLQGIGFDLVI-GADHASVRSPLMGRFNVDNLLAVAGVLYALNYA 318
                AD  A ++  +  G  FD+   G      R  L G  NV N LA   V +     
Sbjct: 267 ---AGADYRAVNVRPDESGTTFDVEFRGERLGEARVSLPGTHNVLNGLAALAVTHLYGGD 323

Query: 319 LSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVF 378
               A  L+      GR   + G+ G  +VV DYAH    +   +   ++   GR + V 
Sbjct: 324 FDRAARALADFHG-PGRRWEIKGERGGALVVDDYAHNATKVASAVQ--AARQTGRRVRVV 380

Query: 379 GCGGERDRGKRSQMA----VIAESNADVVFVTD-----DNPRGEDGDGIVADILAGFARP 429
               +  R  R+Q +      A  +AD V V D     + P       ++ D +     P
Sbjct: 381 ---FQPHRYLRTQQSWPRLADALMDADEVLVLDIAAASETPIEGVHATLITDRMTQGGHP 437

Query: 430 NVVKVQRDRSAAIAAAIGIASAEDVVLIAGKG--HERYQEVAG 470
           N V    DR+A +      A   D+++  G G  +   +EV G
Sbjct: 438 N-VHYCPDRAAVVRDLRESAQPGDIIVTMGAGDVYRIAEEVVG 479


>gi|4377221|gb|AAD19039| (AE001670) Muramoylalanine-Glutamate Ligase
           [Chlamydia pneumoniae]
           Length = 417
           
 Score = 49.2 bits (115), Expect = 8e-05
 Identities = 32/116 (27%), Positives = 50/116 (42%), Gaps = 22/116 (18%)

Query: 108 GVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQL 167
           G+TG+NGKT+T   L    + LG+ +   G +G+ + D +   G                
Sbjct: 105 GITGSNGKTTTTLFLTHLLNTLGIPAIAMGNIGLPILDHMGQPGVR-------------- 150

Query: 168 RDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
                    +E+SS  L             VF N +R+HLDYH +++ Y  AK R+
Sbjct: 151 --------VVEISSFQLATQEEHIPALSGSVFLNFSRNHLDYHRNLDAYFDAKLRI 198


>gi|6919932|sp|Q9X827|MURC_STRCO UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|4691386|emb|CAB41553.2| (AL049727) putative
           UDP-N-acetylmuramoyl-L-alanine ligase [Streptomyces
           coelicolor]
           Length = 462
           
 Score = 48.0 bits (112), Expect = 2e-04
 Identities = 73/278 (26%), Positives = 115/278 (41%), Gaps = 20/278 (7%)

Query: 195 DVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQDVQAA--VINVDDPFGLRLLHGLAKGM 252
           +V +  N+  DH   +  M+    +    FA + V     VI  D      L   LA  +
Sbjct: 179 EVAIVLNVELDHHANYASMDEIYES-FETFAGKIVPGGTLVIAADHEGARELTRRLAGRV 237

Query: 253 RRVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLM--GRFNVDNLLAVAG 310
           R V        DADV    LS+  QG+  ++ +  D A +   +   GR    N +A   
Sbjct: 238 RTVTYGES--EDADVRI--LSVVPQGLKSEVTVVLDGAELTFAVSVPGRHYAHNAVAALA 293

Query: 311 VLYALNYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHV 370
              AL    +E+A  L+    +  R+ +L G+     VV  YAH P  +   L ++ + V
Sbjct: 294 AGAALGVPAAELAPALAAYTGVKRRL-QLKGEAAGVQVVDSYAHHPTEMTADLEAMRAAV 352

Query: 371 C-GRLICVFG---CGGERDRGKRSQMAVIAESNADVVFVTDDNPRGEDG-DGIVADILAG 425
              R++ +F        ++ GK    A+     AD   V D  P  ED   G+ ++++  
Sbjct: 353 GDARILVLFQPHLFSRTQELGKEMGQALAL---ADASVVLDIYPAREDPIPGVTSELIVE 409

Query: 426 FARPNVVKVQ--RDRSAAIAAAIGIASAEDVVLIAGKG 461
            AR     V    D+ A+ A   G+A A D+VL  G G
Sbjct: 410 AARAAGADVTPVHDKDASPALVAGMAKAGDLVLTMGAG 447


>gi|127537|sp|P14900|MURD_ECOLI
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|68625|pir||CEECME
           UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC
           6.3.2.9) - Escherichia coli >gi|40856|emb|CAA38865.1|
           (X55034) UDP-MurNac-L-Ala-D-Glu (MurD) (AA 1-438)
           [Escherichia coli] >gi|42060|emb|CAA35933| (X51584) murD
           gene product (AA 1-438) [Escherichia coli]
           >gi|216502|dbj|BAA01353| (D10483)
           UDP-N-acetylmuramoylalanine-D-glutamate ligase
           [Escherichia coli] >gi|1786276 (AE000118)
           UDP-N-acetylmuramoylalanine-D-glutamate ligase
           [Escherichia coli]
           Length = 438
           
 Score = 46.9 bits (109), Expect = 4e-04
 Identities = 79/359 (22%), Positives = 139/359 (38%), Gaps = 60/359 (16%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +V +TG+NGK++   L+ +     GV     G +G+             P ++       
Sbjct: 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGL-------------PALM------- 146

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLD-YHGDMEHYGAAKARLF 224
            L D+  +   +E+SS  L+      +        N+T DH+D Y   ++ Y AAK R++
Sbjct: 147 -LLDDECELYVLELSSFQLE--TTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIY 203

Query: 225 AHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLV 284
             ++ +  V+N DD   +  + G  +     GV++  +        HL+ + QG  +  V
Sbjct: 204 --ENAKVCVVNADDALTMP-IRGADERCVSFGVNMGDY--------HLN-HQQGETWLRV 251

Query: 285 IGADHASVRS-PLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQD 343
            G    +V+   L G+ N  N LA   +  A     +     L+T   +  R   +   +
Sbjct: 252 KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHN 311

Query: 344 GQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVV 403
           G   +    A    +    L+ L  HV G L  + G       GK +  + +A       
Sbjct: 312 GVRWINDSKATNVGSTEAALNGL--HVDGTLHLLLG-----GDGKSADFSPLAR------ 358

Query: 404 FVTDDNPR----GEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIA 458
           ++  DN R    G DG  + A       RP V +       A+          D+VL++
Sbjct: 359 YLNGDNVRLYCFGRDGAQLAA------LRPEVAEQTETMEQAMRLLAPRVQPGDMVLLS 411


>gi|3122405|sp|O07108|MURD_ENTFA
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|2149905 (U94707)
           D-glutamic acid adding enzyme [Enterococcus faecalis]
           Length = 456
           
 Score = 46.5 bits (108), Expect = 5e-04
 Identities = 38/115 (33%), Positives = 55/115 (47%), Gaps = 19/115 (16%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +VG+TGTNGKT+T  ++    +    R+A    L   +       GF    V Q     A
Sbjct: 114 IVGITGTNGKTTTTTMIGLLLNA--DRTAGEARLAGNI-------GFPASTVAQE----A 160

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAK 220
             +D+    + ME+SS  L    ++  H  + V TN+   HLDYHG  + Y AAK
Sbjct: 161 TAKDD----LVMELSSFQLMG--IETFHPQIAVITNIFEAHLDYHGSRKEYVAAK 209


>gi|4406514|gb|AAD20011| (AF123319)
           UDP-N-acetylmuramoylalanyl-D-glutamate-2,
           6-diaminopimelate ligase MurE [Streptomyces coelicolor]
           Length = 142
           
 Score = 46.5 bits (108), Expect = 5e-04
 Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 3/65 (4%)

Query: 6   PLAQLLPDIPQAR---DVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVA 62
           PLA+L   +  A       I+G+  DSR V+PGD + A+ G   HG  F+  A   GA A
Sbjct: 61  PLAELADQLGVAAPDGSAEITGITHDSRAVRPGDLYAALPGARLHGADFVTQAAGLGAAA 120

Query: 63  ILFEP 67
           +L +P
Sbjct: 121 VLTDP 125


>gi|6919931|sp|Q9WY73|MURC_THEMA UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|4980729|gb|AAD35322.1|AE001707_9 (AE001707)
           UDP-N-acetylmuramate--alanine ligase [Thermotoga
           maritima]
           Length = 457
           
 Score = 46.1 bits (107), Expect = 7e-04
 Identities = 61/265 (23%), Positives = 106/265 (39%), Gaps = 48/265 (18%)

Query: 109 VTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTT---PLVLQLHQCLA 165
           VTGT+GKT+T  ++A     L  R +    LG G+ D +    +     P+V +L +   
Sbjct: 107 VTGTDGKTTTTAMVAHVLKHL--RKSPTVFLG-GIMDSLEHGNYEKGNGPVVYELDE--- 160

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGD-MEHYGAAKARLF 224
                 ++    E S + L             + TN   DHL+ +G+ +  Y +A  ++ 
Sbjct: 161 ------SEEFFSEFSPNYL-------------IITNARGDHLENYGNSLTRYRSAFEKIS 201

Query: 225 AHQDVQAAVINVDDPFGLRL---LHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGF 281
            + D+   V   +D     L     G+ KG   + +      +   M +           
Sbjct: 202 RNTDL--VVTFAEDELTSHLGDVTFGVKKGTYTLEMRSASRAEQKAMVEKN--------- 250

Query: 282 DLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMN-RLG 340
               G  +  ++  + G  NV N LAV  +  +L Y L+ +   L   R +H R +    
Sbjct: 251 ----GKRYLELKLKVPGFHNVLNALAVIALFDSLGYDLAPVLEALEEFRGVHRRFSIAFH 306

Query: 341 GQDGQPVVVVDYAHTPDALGQVLSS 365
             +    V+ DYAHTPD +  +L +
Sbjct: 307 DPETNIYVIDDYAHTPDEIRNLLQT 331


>gi|42046|emb|CAA35611| (X17609)
           UDP-N-acetylmuramoyl-L-alanine:D-gluta ligase (AA 1-438)
           [Escherichia coli]
           Length = 438
           
 Score = 46.1 bits (107), Expect = 7e-04
 Identities = 79/359 (22%), Positives = 139/359 (38%), Gaps = 60/359 (16%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +V +TG+NGK++   L+ +     GV     G +G+             P ++       
Sbjct: 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGL-------------PALM------- 146

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLD-YHGDMEHYGAAKARLF 224
            L D+  +   +E+SS  L+      +        N+T DH+D Y   ++ Y AAK R++
Sbjct: 147 -LLDDECELYVLELSSFQLE--TTSSLQAVTATILNVTEDHMDRYPFGLQQYRAAKLRIY 203

Query: 225 AHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLV 284
             ++ +  V+N DD   +  + G  +     GV++  +        HL+ + QG  +  V
Sbjct: 204 --ENAKVCVVNADDALTMP-IRGADERCVSFGVNMGDY--------HLN-HQQGETWLRV 251

Query: 285 IGADHASVRS-PLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQD 343
            G    +V+   L G+ N  N LA   +  A     +     L+T   +  R   +   +
Sbjct: 252 KGEKVLNVKEMKLSGQHNYTNALARVALADAAGLPRASSLKALTTFTGLPHRFEVVLEHN 311

Query: 344 GQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVV 403
           G   +    A    +    L+ L  HV G L  + G       GK +  + +A       
Sbjct: 312 GVRWINDSKATNVGSTEAALNGL--HVDGTLHLLLG-----GDGKSADFSPLAR------ 358

Query: 404 FVTDDNPR----GEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIA 458
           ++  DN R    G DG  + A       RP V +       A+          D+VL++
Sbjct: 359 YLNGDNVRLYCFGRDGAQLAA------LRPEVAEQTETMEQAMRLLAPRVQPGDMVLLS 411


>gi|6225736|sp|O05953|MURF_RICPR PROBABLE
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,
           6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE
           (UDP-MURNAC-PENTAPEPTIDE SYNTHETASE)
           (D-ALANYL-D-ALANINE-ADDING ENZYME)
           >gi|3861140|emb|CAA15040| (AJ235272)
           UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-
           2,6-DIAMINOPIMELATE--D-ALANYL-D-ALANYL LIGASE (murF)
           [Rickettsia prowazekii]
           Length = 449
           
 Score = 45.7 bits (106), Expect = 9e-04
 Identities = 73/346 (21%), Positives = 139/346 (40%), Gaps = 33/346 (9%)

Query: 28  DSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAIAVHGLRA 87
           +S++V+ GD F+A+ G    G  +I+DA  +GA A++        ++  D  I V+    
Sbjct: 28  NSKDVKKGDLFIALQG-NRDGHDYIQDAIDKGATAVIVSKQVE--INDKDKIILVNNSFE 84

Query: 88  RLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQV 147
            L  MA   +   +     + +TG+ GKTST + L        +  A+ G          
Sbjct: 85  ALQKMA--LYKRENSKAKFIAITGSVGKTSTKEALKILLQHDFIVFASRG---------- 132

Query: 148 VPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDG----VHYDVVVFTNLT 203
               F   L L ++  LA + D+   A+     +H   QG +      +  ++ +  N++
Sbjct: 133 ---NFNNYLGLLIN--LASMADDTEYAIFELGMNH---QGEISELVQILKPNIAMINNIS 184

Query: 204 RDHLDYHGDMEHYGAAKARLFAH-QDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGH 262
             HL++   +E    AK  +F +      A+IN  +    ++L  + K +    +   GH
Sbjct: 185 EAHLEFFHSLEEIAEAKCEIFKNFSKNDIAIINASNNCYNKIL-SILKNLSITNIYSFGH 243

Query: 263 TDADVMAQHLSLNL-QGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSE 321
           +        L   L + +     I      +  P + R   +N   V  ++  L   +  
Sbjct: 244 SSKASAKLILYKTLGEQVHLQYYINNKFIDITIPFIPRHFANNYTGVLLIIDILGKDIEI 303

Query: 322 IAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAH-TPDALGQVLSSL 366
            A  L+ +    GR   +  Q+ +  V+ DY + +P ++   L  L
Sbjct: 304 SAKYLADIALTKGRGKIINIQNSR--VICDYYNASPQSMKAALEYL 347


>gi|3329218|gb|AAC68351.1| (AE001348)
           UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminoligase
           [Chlamydia trachomatis]
           Length = 450
           
 Score = 45.7 bits (106), Expect = 9e-04
 Identities = 33/101 (32%), Positives = 51/101 (49%), Gaps = 11/101 (10%)

Query: 22  ISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAIL----FEPPAPQGVSVPD 77
           ++G+ +DSR V PGD F A+ G    G  F++ A   GAVA +    +  P+  G+ +  
Sbjct: 25  VTGVAIDSRFVLPGDVFFALPGNRTSGHLFLKQAAQSGAVAAVVASDYHGPS-YGLQLLR 83

Query: 78  GAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTST 118
            A     LRA        F+G       ++G+TG+ GKT+T
Sbjct: 84  VADPREALRAAGRTQGALFYGE------VIGITGSVGKTTT 118


>gi|556014 (L31845) UDP-N-acetyl muramate-alanine ligase [Bacillus
           subtilis]
           Length = 348
           
 Score = 44.5 bits (103), Expect = 0.002
 Identities = 68/264 (25%), Positives = 96/264 (35%), Gaps = 40/264 (15%)

Query: 95  RFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTT 154
           +F G   +  T V VTG +GKTST  LLA   H +     T   +G G       TG   
Sbjct: 8   KFLGDYMKKFTSVAVTGAHGKTSTTGLLA---HVIQNAKPTSFLIGDG-------TG--- 54

Query: 155 PLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDME 214
                          E     A E   H L          D  + TN+  DH DY   ++
Sbjct: 55  ---------QGNENSEYFVFEACEYRRHFLSY------QPDYAIMTNIDFDHPDYFSSID 99

Query: 215 HYGAAKARLFAHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCG-HTDADVMAQHLS 273
               A   +     V   +I   D   L  +H        V V   G   + D  A+++ 
Sbjct: 100 DVFDAFQEMAL--QVNKGIIACGDDEHLPKIHA------NVPVVYYGTGEENDFQARNIV 151

Query: 274 LNLQGIGFDLVI-GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPI 332
            + +G  FD+ +    + +   P  G  NV N LAV  + +      S I   L +   +
Sbjct: 152 KSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDSSIIKHALKSFGGV 211

Query: 333 HGRMNRLGGQDGQPVVVVDYAHTP 356
             R N    Q G  V++ DYAH P
Sbjct: 212 KRRFNE--KQLGDQVLIDDYAHHP 233


>gi|3183540|sp|P40778|MURC_BACSU UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|2293216 (AF008220) putative
           UDP-N-acetylmuramate-alanine ligase [Bacillus subtilis]
           >gi|2635463|emb|CAB14957| (Z99119) UDP-N-acetyl
           muramate-alanine ligase [Bacillus subtilis]
           Length = 432
           
 Score = 44.5 bits (103), Expect = 0.002
 Identities = 68/264 (25%), Positives = 96/264 (35%), Gaps = 40/264 (15%)

Query: 95  RFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTT 154
           +F G   +  T V VTG +GKTST  LLA   H +     T   +G G       TG   
Sbjct: 92  KFLGDYMKKFTSVAVTGAHGKTSTTGLLA---HVIQNAKPTSFLIGDG-------TG--- 138

Query: 155 PLVLQLHQCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDME 214
                          E     A E   H L          D  + TN+  DH DY   ++
Sbjct: 139 ---------QGNENSEYFVFEACEYRRHFLSY------QPDYAIMTNIDFDHPDYFSSID 183

Query: 215 HYGAAKARLFAHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCG-HTDADVMAQHLS 273
               A   +     V   +I   D   L  +H        V V   G   + D  A+++ 
Sbjct: 184 DVFDAFQEMAL--QVNKGIIACGDDEHLPKIHA------NVPVVYYGTGEENDFQARNIV 235

Query: 274 LNLQGIGFDLVI-GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPI 332
            + +G  FD+ +    + +   P  G  NV N LAV  + +      S I   L +   +
Sbjct: 236 KSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCHYEEIDSSIIKHALKSFGGV 295

Query: 333 HGRMNRLGGQDGQPVVVVDYAHTP 356
             R N    Q G  V++ DYAH P
Sbjct: 296 KRRFNE--KQLGDQVLIDDYAHHP 317


>gi|2981818|pdb|1UAG|  Udp-N-Acetylmuramoyl-L-Alanine:d-Glutamate
           Ligase
           Length = 437
           
 Score = 44.5 bits (103), Expect = 0.002
 Identities = 78/359 (21%), Positives = 138/359 (37%), Gaps = 60/359 (16%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +V +TG+NGK++   L+ +     GV     G +G+             P ++       
Sbjct: 106 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGL-------------PALM------- 145

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLD-YHGDMEHYGAAKARLF 224
            L D+  +   +E+SS  L+      +        N+T DH+D Y   ++ Y AA  R++
Sbjct: 146 -LLDDECELYVLELSSFQLE--TTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAXLRIY 202

Query: 225 AHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDLV 284
             ++ +  V+N DD   +  + G  +     GV++  +        HL+ + QG  +  V
Sbjct: 203 --ENAKVCVVNADDALTMP-IRGADERCVSFGVNMGDY--------HLN-HQQGETWLRV 250

Query: 285 IGADHASVRS-PLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQD 343
            G    +V+   L G+ N  N LA   +  A     +     L+T   +  R   +   +
Sbjct: 251 KGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHN 310

Query: 344 GQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADVV 403
           G   +    A    +    L+ L  HV G L  + G       GK +  + +A       
Sbjct: 311 GVRWINDSKATNVGSTEAALNGL--HVDGTLHLLLG-----GDGKSADFSPLAR------ 357

Query: 404 FVTDDNPR----GEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAEDVVLIA 458
           ++  DN R    G DG  + A       RP V +       A+          D+VL++
Sbjct: 358 YLNGDNVRLYCFGRDGAQLAA------LRPEVAEQTETMEQAMRLLAPRVQPGDMVLLS 410


>gi|6919929|sp|P94335|MURC_CORGL UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|3868935|dbj|BAA34293| (AB015023) MurC
           [Corynebacterium glutamicum]
           Length = 486
           
 Score = 44.1 bits (102), Expect = 0.003
 Identities = 98/391 (25%), Positives = 145/391 (37%), Gaps = 60/391 (15%)

Query: 98  GHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLV 157
           G   +  T V + GT+GKTST  +   A    G+  +      +G               
Sbjct: 113 GELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPS----FAIG--------------- 153

Query: 158 LQLHQCLAQLRDEGAQAV--AMEVSSHALDQGRVDGVHY--DVVVFTNLTRDHLDYHGDM 213
                   QL   G  A     EV     D+     + Y  +V V TN+  DHLD+    
Sbjct: 154 -------GQLNKAGTNAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTP 206

Query: 214 EHYGAA----KARLFAHQDVQAAVINVDDPFGLRL-LHGLAKGMRRVGV----SVCGHTD 264
           E Y         R+  +  +   V+ ++DP    L    + KG++ VG     +V  H +
Sbjct: 207 EAYFQVFDDFAGRITPNGKL---VVCLNDPHAAELGERSVRKGIKTVGYGTADAVQAHPE 263

Query: 265 ADVMAQHLSLNLQGIGFDLVIGAD--HASVRSPLMGRFNVDN----LLA---VAGVLYAL 315
              MA  +   +   G    I  D    SV   + G   V N    LLA   V G +  L
Sbjct: 264 VPAMATIVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDVDKL 323

Query: 316 NYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHV----C 371
              LS+ + V       HG +   GG+     +  DYAH P  +  VLS+  + V     
Sbjct: 324 VEGLSDFSGVRRRFE-FHGAIE--GGKFNGAAIYDDYAHHPTEVTAVLSAARTRVKAAGK 380

Query: 372 GRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTD-DNPRGEDGDGIVADILAGFARPN 430
           GR+I  F         +  +    A S AD   V +    R +  DG+ ++I+   A   
Sbjct: 381 GRVIVAFQPHLYSRTMEFQKEFAEALSLADAAVVLEIYGAREQPVDGVSSEIITD-AMTI 439

Query: 431 VVKVQRDRSAAIAAAIGIASAEDVVLIAGKG 461
            V  + + SA       IA   D+VL  G G
Sbjct: 440 PVVYEPNFSAVPERIAEIAGPNDIVLTMGAG 470


>gi|3329220|gb|AAC68353.1| (AE001348)
           UDP-N-acetylmuramoylalanine-D-glutamate ligase
           [Chlamydia trachomatis]
           Length = 416
           
 Score = 43.8 bits (101), Expect = 0.003
 Identities = 33/117 (28%), Positives = 50/117 (42%), Gaps = 22/117 (18%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           + +TGT GKT+T+  L   +   G+ +   G +G+ + D     G   P V  +     Q
Sbjct: 104 LAITGTTGKTTTILFLEYLFKRSGIPAFAMGNVGIPILD-----GMQNPGVRIVEISSFQ 158

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
           L D+       E S   L  G +           N++ +HLDYHG+   Y  AK  L
Sbjct: 159 LADQ-------EKSYPVLSGGMI----------LNISDNHLDYHGNFSEYFQAKQNL 198


>gi|2149895 (U94706) D-glutamic acid adding enzyme [Staphylococcus
           aureus]
           Length = 450
           
 Score = 42.6 bits (98), Expect = 0.008
 Identities = 39/168 (23%), Positives = 69/168 (40%), Gaps = 32/168 (19%)

Query: 63  ILFEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLL 122
           I+  P  P  VS+ D A+     +  L  + +    +      ++ VTGTNGKT+   L+
Sbjct: 75  IVKNPGIPYTVSIIDEAV-----KRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLI 129

Query: 123 AQAW---HCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEV 179
              +      G  S   G +   +  +V PT +                      +  E+
Sbjct: 130 GDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDY----------------------LVTEL 167

Query: 180 SSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQ 227
           SS  L    ++     + + TN+   HLDYH ++E+Y  AK +++ +Q
Sbjct: 168 SSFQL--LGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQ 213


>gi|3122409|sp|O33595|MURD_STAAU
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|2271510 (AF009671)
           UDP-N-acetylmuramoyl-L-alanine : D-glutamate ligase;
           MurD [Staphylococcus aureus]
           Length = 449
           
 Score = 42.6 bits (98), Expect = 0.008
 Identities = 39/168 (23%), Positives = 69/168 (40%), Gaps = 32/168 (19%)

Query: 63  ILFEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLL 122
           I+  P  P  VS+ D A+     +  L  + +    +      ++ VTGTNGKT+   L+
Sbjct: 75  IVKNPGIPYTVSIIDEAV-----KRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLI 129

Query: 123 AQAW---HCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEV 179
              +      G  S   G +   +  +V PT +                      +  E+
Sbjct: 130 GDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDY----------------------LVTEL 167

Query: 180 SSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQ 227
           SS  L    ++     + + TN+   HLDYH ++E+Y  AK +++ +Q
Sbjct: 168 SSFQL--LGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQ 213


>gi|2463563|dbj|BAA22556| (AB007500) MURD [Staphylococcus aureus]
           Length = 269
           
 Score = 42.6 bits (98), Expect = 0.008
 Identities = 39/168 (23%), Positives = 69/168 (40%), Gaps = 32/168 (19%)

Query: 63  ILFEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLL 122
           I+  P  P  VS+ D A+     +  L  + +    +      ++ VTGTNGKT+   L+
Sbjct: 75  IVKNPGIPYTVSIIDEAV-----KRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLI 129

Query: 123 AQAW---HCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLRDEGAQAVAMEV 179
              +      G  S   G +   +  +V PT +                      +  E+
Sbjct: 130 GDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDY----------------------LVTEL 167

Query: 180 SSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQ 227
           SS  L    ++     + + TN+   HLDYH ++E+Y  AK +++ +Q
Sbjct: 168 SSFQL--LGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQ 213


>gi|6723459|emb|CAB66325.1| (AJ242646) MurC protein [Brevibacterium
           lactofermentum]
           Length = 486
           
 Score = 42.2 bits (97), Expect = 0.010
 Identities = 97/391 (24%), Positives = 144/391 (36%), Gaps = 60/391 (15%)

Query: 98  GHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLV 157
           G   +  T V + GT+GKTST  +   A    G+  +      +G               
Sbjct: 113 GELLEGSTQVLIAGTHGKTSTTSMSVVAMQAAGMDPS----FAIG--------------- 153

Query: 158 LQLHQCLAQLRDEGAQAV--AMEVSSHALDQGRVDGVHY--DVVVFTNLTRDHLDYHGDM 213
                   QL   G  A     EV     D+     + Y  +V V TN+  DHLD+    
Sbjct: 154 -------GQLNKAGTNAHHGTGEVFIAEADESDASLLRYKPNVAVVTNVEPDHLDFFKTP 206

Query: 214 EHYGAA----KARLFAHQDVQAAVINVDDPFGLRL-LHGLAKGMRRVGV----SVCGHTD 264
           E Y         R+  +  +   V+ ++DP    L    + KG++ VG     +V  H +
Sbjct: 207 EAYFQVFDDFAGRITPNGKL---VVCLNDPHAAELGERSVRKGIKTVGYGTRDAVQAHPE 263

Query: 265 ADVMAQHLSLNLQGIGFDLVIGAD--HASVRSPLMGRFNVDN----LLA---VAGVLYAL 315
              MA  +   +   G    I  D    SV   + G   V N    LLA   V G +  L
Sbjct: 264 VPAMATVVDSQVVAEGTRATINIDGQEVSVILQIPGDHMVLNGAAALLAGYLVGGDVDKL 323

Query: 316 NYALSEIAAVLSTLRPIHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHV----C 371
              LS+ + V       HG +   GG+     +  DYAH P  +  VL   ++ V     
Sbjct: 324 VEGLSDFSGVRRRFE-FHGAIE--GGKFNGAAIYDDYAHHPTEVTAVLRRCATRVKAAGK 380

Query: 372 GRLICVFGCGGERDRGKRSQMAVIAESNADVVFVTD-DNPRGEDGDGIVADILAGFARPN 430
           GR+I  F         +  +    A S AD   V +    R +  DG+ ++I+   A   
Sbjct: 381 GRVIVAFQPHLYSRTMEFQKEFAEALSLADAAVVLEIYGAREQPVDGVSSEIITD-AMTI 439

Query: 431 VVKVQRDRSAAIAAAIGIASAEDVVLIAGKG 461
            V  + + SA       IA   D+VL  G G
Sbjct: 440 PVVYEPNFSAVPERIAEIAGPNDIVLTMGAG 470


>gi|1169724|sp|P43775|FOLC_HAEIN FOLYLPOLYGLUTAMATE SYNTHASE
           (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS)
           >gi|1074089|pir||C64113 folylpolyglutamate synthase
           (folC) homolog - Haemophilus influenzae (strain Rd KW20)
           >gi|1574719 (U32806) folylpolyglutamate
           synthase/dihydrofolate synthase (folC) [Haemophilus
           influenzae Rd]
           Length = 437
           
 Score = 42.2 bits (97), Expect = 0.010
 Identities = 35/122 (28%), Positives = 56/122 (45%), Gaps = 10/122 (8%)

Query: 346 PVVVVDYAHTPDA---LGQVLSSLSSHVCGRLICVFGCGGERDRGKRSQMAVIAESNADV 402
           P ++VD  H P A   L + L++L   + G++I V  CG  +D+        +     + 
Sbjct: 311 PTIIVDVGHNPHAAKYLSEKLTALKRSIEGKMIAV--CGMLKDKDANGVFEHLTPIIDEW 368

Query: 403 VFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSA--AIAAAIGIASAEDVVLIAGK 460
             VT    RG+ GD +V  + + F  PN ++   D S    +  A+  A   DVVL+ G 
Sbjct: 369 HCVTLGGYRGQSGDELVEKLKSHF--PN-IQATSDNSVMDGVCTALKSAVKNDVVLVFGS 425

Query: 461 GH 462
            H
Sbjct: 426 FH 427


>gi|4009466 (AF068901) D-Ala-D-Ala adding enzyme [Streptococcus
           pneumoniae]
           Length = 457
           
 Score = 40.6 bits (93), Expect = 0.030
 Identities = 50/159 (31%), Positives = 65/159 (40%), Gaps = 23/159 (14%)

Query: 13  DIPQARDVVISGLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQG 72
           DI    D  +     DSR +  GD FV + G    G  FIE A   GA   L E      
Sbjct: 17  DISIFEDTQLEKAEFDSRLIGTGDLFVPLKG-ARDGHDFIETAFENGAAVTLSEKEVSNH 75

Query: 73  --VSVPDGAIAVHGLRARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLAQAWHCLG 130
             + V D   A   L +         +      + +  VTG+NGKT+T  +LA   H L 
Sbjct: 76  PYILVDDVLTAFQSLAS---------YYLEKTTVDVFAVTGSNGKTTTKDMLA---HLLS 123

Query: 131 VRSATCGTLG-----VGLYDQV--VPTGFTTPLVLQLHQ 162
            R  T  T G     +GL   V  +P G T  LVL++ Q
Sbjct: 124 TRYKTYKTQGNYNNEIGLPYTVLHMPEG-TEKLVLEMGQ 161


>gi|3123061|sp|O26631|Y531_METTH HYPOTHETICAL PROTEIN MTH531
           >gi|2621605 (AE000836) UDP-N-acetylmuramyl tripeptide
           synthetase related protein [Methanobacterium
           thermoautotrophicum]
           Length = 312
           
 Score = 39.5 bits (90), Expect = 0.067
 Identities = 58/214 (27%), Positives = 82/214 (38%), Gaps = 38/214 (17%)

Query: 44  FGAHGLCFIEDACARGAVAILFEPP--APQGVSVPDGAIAVHGLRARLGAMADRFHGHPS 101
           FG H +   ED     AV I    P  AP    V +    VH   + +G   +   G P 
Sbjct: 61  FGGHSM---EDILWADAVFISPNIPQDAPVRKMVREAGDLVHITTSDIGRTLNELIGLP- 116

Query: 102 QAMTMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLH 161
               MVGV GT+GKT+T  ++    H L  R  T       L D +V  G    +V    
Sbjct: 117 ----MVGVAGTDGKTTTTNMID---HILSSRYRTVSF--SSLQDSLVIEGLVELVV---- 163

Query: 162 QCLAQLRDEGAQAVAMEVSSHALDQGRV---DGVHYDVVVFTNLTRDHLDYHGDMEHYGA 218
                           +++   L  G +   +G+     V TNLT DH+D   +  +Y  
Sbjct: 164 ---------NGDIDDRDLAVFELPHGTIRMAEGLELSAGVVTNLTPDHMD---EFSNYDE 211

Query: 219 AKARLFAHQDVQA----AVINVDDPFGLRLLHGL 248
              R F+ +D+ A      +  DDP    LL  L
Sbjct: 212 YIERNFSIKDLMAPGGVLALCGDDPVISSLLDDL 245


>gi|3915767|sp|Q51831|MURC_PORGI UDP-N-ACETYLMURAMATE--ALANINE
           LIGASE (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|2780743|dbj|BAA24358| (D84504) MurC [Porphyromonas
           gingivalis]
           Length = 433
           
 Score = 38.3 bits (87), Expect = 0.15
 Identities = 63/278 (22%), Positives = 107/278 (37%), Gaps = 47/278 (16%)

Query: 109 VTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLR 168
           V GT+GKT+T  LLA   H L      C     G     +   + + L+L     L  + 
Sbjct: 112 VAGTHGKTTTSTLLA---HLLKQSHVDCNAFLGG-----ISNNYQSNLLLSDKSDLVVV- 162

Query: 169 DEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAH-- 226
               +A   + S H L           + + T+   DH+D +G  E+Y  +    F H  
Sbjct: 163 ----EADEFDRSFHHLKPF--------MAIITSADPDHMDIYGTAENYRDS----FEHFT 206

Query: 227 ---QDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDL 283
              Q   A V+    P   RL            VS+  ++  D  A + + ++      L
Sbjct: 207 SLIQSGGALVLKYGAPVNPRL---------GSDVSLFTYSSDDRQADYFASDIMIRDGRL 257

Query: 284 VI-----GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNR 338
                  G     V   +  R NV+N +A   + +     + E+ + +++ +  H R  +
Sbjct: 258 FFTWHYPGGQLEEVELGVPVRINVENAVAAMAIAHLNGVTVEELRSGIASFKGSHRRFEK 317

Query: 339 LGGQDGQPVVVV-DYAHTPDALGQVLSSLSSHVCGRLI 375
           +   D + VV++ DYAH P  L   + S+     G+ I
Sbjct: 318 V--LDTERVVLIDDYAHHPVELDAAIRSVREIYSGKHI 353


>gi|127536|sp|P17952|MURC_ECOLI UDP-N-ACETYLMURAMATE--ALANINE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANINE SYNTHETASE)
           >gi|68624|pir||CEECAM UDP-N-acetylmuramate--alanine
           ligase (EC 6.3.2.8) - Escherichia coli
           >gi|40859|emb|CAA38868.1| (X55034)
           UDP-N-acetylmuramate--alanine ligase [Escherichia coli]
           >gi|42056|emb|CAA36868| (X52644) (UDP-N-acetylmuramate:
           L-alanine ligase)  (AA 1-491) [Escherichia coli]
           >gi|216505|dbj|BAA01356| (D10483)
           UDP-N-acetylmuramate-alanine ligase [Escherichia coli]
           >gi|1786279 (AE000118) L-alanine adding enzyme,
           UDP-N-acetyl-muramate:alanine ligase [Escherichia coli]
           >gi|228660|prf||1808265A murC gene [Escherichia coli]
           Length = 491
           
 Score = 37.9 bits (86), Expect = 0.20
 Identities = 45/174 (25%), Positives = 66/174 (37%), Gaps = 19/174 (10%)

Query: 196 VVVFTNLTRDHLD-YHGDMEHYGAAKARLFAHQDVQA-AVINVDDPFGLRLLHGLAKGMR 253
           V + TN+  DH+D Y GD E+          +      AV+ VDDP    LL  + +   
Sbjct: 189 VAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTT 248

Query: 254 RVGVSVCGHTDADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLY 313
             G S     DADV  +     +   G   ++  D   +R  L      + L A A V  
Sbjct: 249 TYGFS----EDADVRVEDYQ-QIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAV 303

Query: 314 ALNYALSEIAAVLSTLRPIHGRMNR-----------LGGQDGQPVVVVDYAHTP 356
           A    + +  A+L  L    G   R           + G+ G  ++V DY H P
Sbjct: 304 ATEEGIDD-EAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHP 356


>gi|3914074|sp|O51532|MURD_BORBU
           UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE
           (UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE SYNTHETASE)
           (D-GLUTAMIC ACID ADDING ENZYME) >gi|2688512 (AE001160)
           UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
           [Borrelia burgdorferi]
           Length = 451
           
 Score = 37.9 bits (86), Expect = 0.20
 Identities = 33/129 (25%), Positives = 56/129 (42%), Gaps = 21/129 (16%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           +V VTGT GK++ V LL QA           G +GV       P  F   L         
Sbjct: 113 IVAVTGTKGKSTLVSLLYQALKEKYPGVKLGGNIGVS------PLSFFDQL--------- 157

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFA 225
               +G   + +E+SS  L    ++  +  + + TN+  DH +Y+ + + Y   K+++F 
Sbjct: 158 ----DGKSPLILELSSWQLQS--LENFNPIISIITNVYNDHQNYYLNFDDYIIDKSKIFV 211

Query: 226 HQDVQAAVI 234
           +Q     +I
Sbjct: 212 NQTSGIVII 220


>gi|2960136|emb|CAA18034.1| (AL022121) hypothetical protein Rv3712
           [Mycobacterium tuberculosis]
           Length = 413
           
 Score = 37.5 bits (85), Expect = 0.26
 Identities = 44/133 (33%), Positives = 56/133 (42%), Gaps = 20/133 (15%)

Query: 107 VGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQ 166
           V VTGTNGK++T ++ A          A  GTLG      V        +   L   LA 
Sbjct: 54  VVVTGTNGKSTTTRMTA----------AALGTLGA-----VATNAEGANMDAGLVAALAA 98

Query: 167 LRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHY-GAAKARLFA 225
            RD  A+   +EV    +     D V   VVV  NL+RD LD  G++       +A L  
Sbjct: 99  HRD--AELAVLEVDEMHVPH-ISDAVDPAVVVLLNLSRDQLDRVGEINVIERTLRAGLAR 155

Query: 226 HQDVQAAVINVDD 238
           H D    V N DD
Sbjct: 156 HPDA-VVVANCDD 167


>gi|2984290 (AE000771) UDP-N-acetylmuramoylalanine-D-glutamate
           ligase [Aquifex aeolicus]
           Length = 415
           
 Score = 37.1 bits (84), Expect = 0.34
 Identities = 55/262 (20%), Positives = 108/262 (40%), Gaps = 43/262 (16%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           ++ +TGT+GK++T +L                 +    +D+V   G        + +  +
Sbjct: 86  VIAITGTDGKSTTTRLTY--------------LILKKFFDEVFEAG-------NIGKPFS 124

Query: 166 QLRDEGAQAVA-MEVSSHALDQGR-VDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
           ++  E  + +A +EVSS    QG+ +     ++  F + + DHLD+H  +E Y  +K R+
Sbjct: 125 EVVLENPEGIAVLEVSSF---QGKTLKTFRPNIGAFISFSVDHLDWHPSIEDYLKSKYRI 181

Query: 224 FAHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDL 283
           F +Q  +  +I  D      L++ + K   R            V+   L +N   + +  
Sbjct: 182 FENQTEEDFLILND------LVYEIKKTPSRA---------RKVLFSELYINSDSVFYKD 226

Query: 284 VIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQD 343
           +   +  +++  + G  NV N    + +   L     +   V+   R +  R+  LG  +
Sbjct: 227 IRLFNPKNLK--IRGLHNVYNASVASLIALTLGLKPEDFEEVIYEFRGLPHRLEFLGNFN 284

Query: 344 GQPVVVVDYAHTPDALGQVLSS 365
           G  V     + TP AL   L +
Sbjct: 285 GVEVYNDSKSTTPHALMHALKT 306


>gi|2213499|emb|CAB09757| (Z97050) adhE [Mycobacterium tuberculosis]
           Length = 383
           
 Score = 37.1 bits (84), Expect = 0.34
 Identities = 31/106 (29%), Positives = 49/106 (45%), Gaps = 10/106 (9%)

Query: 24  GLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAIAVH 83
           G V++  + QPG + VAV G G  G+  +  A     V ++     P+ +S    A+  H
Sbjct: 195 GAVLNVGDPQPGQS-VAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK-ALGAH 252

Query: 84  GL----RARLG----AMADRFHGHPSQAMTMVGVTGTNGKTSTVQL 121
            +    +A  G    A+     GHP+   T +G+T   G+T TV L
Sbjct: 253 EIYTPQQATAGGVKAAVVVEAVGHPAALHTAIGLTAPGGRTITVGL 298


>gi|4154982 (AE001479) UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE
           LIGASE [Helicobacter pylori J99]
           Length = 422
           
 Score = 37.1 bits (84), Expect = 0.34
 Identities = 29/119 (24%), Positives = 56/119 (46%), Gaps = 25/119 (21%)

Query: 105 TMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCL 164
           TM+ ++GTNGKT+T ++L         ++ + G +G             TPL+       
Sbjct: 96  TMISISGTNGKTTTTEMLTTLLE--DFKAVSGGNIG-------------TPLI------- 133

Query: 165 AQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
            +L ++ +    +E SS +L     +  +  + +  N+  DHL +H + E+Y  AK ++
Sbjct: 134 -ELFEKRSPLWVLETSSFSLHY--TNKAYPLIYLLINVEADHLTWHCNFENYLNAKLKV 189


>gi|6708108|gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase
           [Streptococcus thermophilus]
           Length = 500
           
 Score = 36.7 bits (83), Expect = 0.44
 Identities = 44/164 (26%), Positives = 68/164 (40%), Gaps = 23/164 (14%)

Query: 325 VLSTLRP-IHGRMNRLGGQDGQPVVVVDYAHTPDALGQVLSSLSSHVCGRLICVFGCGGE 383
           +++TL P +  R  +  G+DG     +D    PDA  + ++ L           F  G  
Sbjct: 7   IVATLGPAVEIRGGKKFGEDGYWSEKLD----PDASAKNIAQLIEEGANVFRFNFSHGNH 62

Query: 384 RDRGKRSQMAVIAESNAD--VVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSAA 441
            ++G+R  +  +AES A   V F+ D       G  I  ++  G A+    K        
Sbjct: 63  AEQGERMDVVRMAESIAGQKVGFLLDTK-----GPEIRTELFEGDAKEYAYKT--GEQIR 115

Query: 442 IAAAIGIASAEDVVLIAGKGHERYQEVAGVRHPFDDTEVARRVL 485
           IA   G+ S  DV+ +          VAG    FDD EV ++VL
Sbjct: 116 IATKQGLKSTRDVIAL---------NVAGALDIFDDVEVGKQVL 150


>gi|2313605|gb|AAD07560.1| (AE000564)
           UDP-N-acetylmuramoylalanine-D-glutamate ligase (murD)
           [Helicobacter pylori 26695]
           Length = 422
           
 Score = 36.4 bits (82), Expect = 0.58
 Identities = 28/119 (23%), Positives = 56/119 (46%), Gaps = 25/119 (21%)

Query: 105 TMVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCL 164
           T++ ++GTNGKT+T ++L         ++ + G +G             TPL+       
Sbjct: 96  TIISISGTNGKTTTTEMLTMLLE--DFKAVSGGNIG-------------TPLI------- 133

Query: 165 AQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
            +L ++ +    +E SS +L     +  +  + +  N+  DHL +H + E+Y  AK ++
Sbjct: 134 -ELFEKRSPLWVLETSSFSLHY--TNKAYPLIYLLINIEADHLTWHCNFENYLNAKLKV 189


>gi|703269|gb|AAB38420.1| (L39938) histidine protein kinase
           [Sinorhizobium meliloti]
           Length = 433
           
 Score = 34.8 bits (78), Expect = 1.7
 Identities = 26/86 (30%), Positives = 38/86 (43%), Gaps = 7/86 (8%)

Query: 389 RSQMAVIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGI 448
           R ++ V  E   + V VT +    +DG+G   DILA    P V + Q+D S   A  +G+
Sbjct: 336 RKKVTVTTEHTPERVRVTIE----DDGEGFSPDILARIGEPYVTRRQKDDS---AGGLGL 388

Query: 449 ASAEDVVLIAGKGHERYQEVAGVRHP 474
                  L+   G     E  G +HP
Sbjct: 389 GLFIAKTLLERSGARLRFENGGAKHP 414


>gi|3219995|sp|P37773|MPL_ECOLI
           UDP-N-ACETYLMURAMATE:L-ALANYL-GAMMA-D-GLUTAMYL-MESO-
           DIAMINOPIMELATE LIGASE (MUREIN PEPTIDE LIGASE)
           >gi|1361182|pir||S56459 hypothetical protein o457 -
           Escherichia coli >gi|537075 (U14003) ORF_o457
           [Escherichia coli] >gi|1790680 (AE000494) putative
           ligase [Escherichia coli]
           Length = 457
           
 Score = 34.0 bits (76), Expect = 2.9
 Identities = 60/277 (21%), Positives = 100/277 (35%), Gaps = 29/277 (10%)

Query: 106 MVGVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLA 165
           ++ V GT+GKT+T  +        G +         G     VP  F         +  A
Sbjct: 105 VLAVAGTHGKTTTAGMATWILEQCGYKP--------GFVIGGVPGNF---------EVSA 147

Query: 166 QLRDEGAQAVAMEVSSHALDQGRVDGVHY--DVVVFTNLTRDHLDYHGDMEHYGAAKARL 223
            L +     +  +    A    R   VHY    ++  NL  DH D   D++        L
Sbjct: 148 HLGESDFFVIEADEYDCAFFDKRSKFVHYCPRTLILNNLEFDHADIFDDLKAIQKQFHHL 207

Query: 224 FAHQDVQAAVINVDDPFGLRLLHGLAKGMRRVGVSVCGHTDADVMAQHLSLNLQGIGFDL 283
                 Q  +I  ++   L+    +     +  V   GH  A  +    S       +++
Sbjct: 208 VRIVPGQGRIIWPENDINLKQTMAMGCWSEQELVGEQGHWQAKKLTTDAS------EWEV 261

Query: 284 VI-GADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIAAVLSTLRPIHGRMNRLGGQ 342
           ++ G     V+  L+G  N+ N L        +  A ++ A  L +      R+   G  
Sbjct: 262 LLDGEKVGEVKWSLVGEHNMHNGLMAIAAARHVGVAPADAANALGSFINARRRLELRGEA 321

Query: 343 DGQPVVVVDYAHTPDALGQVLSSLSSHVCG--RLICV 377
           +G   V  D+AH P A+   L++L   V G  R+I V
Sbjct: 322 NGV-TVYDDFAHHPTAILATLAALRGKVGGTARIIAV 357


>gi|1405772|emb|CAA98937| (Z74410) nrp [Mycobacterium tuberculosis]
            Length = 2512
            
 Score = 34.0 bits (76), Expect = 2.9
 Identities = 58/230 (25%), Positives = 86/230 (37%), Gaps = 38/230 (16%)

Query: 7    LAQLLPDIPQARDVVISGLVMDSREVQPGDAFVA--VAGFGAH-GLC--FIEDACARGAV 61
            LA  +  IP+A  V      M  RE+      +A  +AG GA  G C   + + CA   V
Sbjct: 1498 LAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCGAGPGECVALLFERCAPAVV 1557

Query: 62   AIL-----------FEPPAPQ-------GVSVPDGAIAVHGLRARLGAMADRFHGHPSQA 103
            A++            +P  P        G +VP  A+   GLR+RL        GH    
Sbjct: 1558 AMVAVLKTGAAYLPIDPANPPPRVAFMLGDAVPVAAVTTAGLRSRLA-------GHDLPI 1610

Query: 104  MTMV-GVTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTT-PLVLQLH 161
            + +V  +    G    +       + L     T    GVG+  + V   F + P  L   
Sbjct: 1611 IDVVDALAAYPGTPPPMPAAVNLAYILYTSGTTGEPKGVGITHRNVTRLFASLPARLSAA 1670

Query: 162  QCLAQLRDEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHG 211
            Q  +Q    G  A A E+    L  GR+      V+V  ++     D+HG
Sbjct: 1671 QVWSQCHSYGFDASAWEIWGALLGGGRL------VIVPESVAASPNDFHG 1714


>gi|3150111|emb|CAA19164.1| (AL023596) hypothetical protein
           MLCB2407.24c [Mycobacterium leprae]
           Length = 411
           
 Score = 33.6 bits (75), Expect = 3.8
 Identities = 34/130 (26%), Positives = 46/130 (35%), Gaps = 16/130 (12%)

Query: 109 VTGTNGKTSTVQLLAQAWHCLGVRSATCGTLGVGLYDQVVPTGFTTPLVLQLHQCLAQLR 168
           VTGTNGK++T ++   A   L   S      G  +       G    L       LA L 
Sbjct: 56  VTGTNGKSTTTRMTVDALSTLAPGSVATNAEGANM-----DAGLVAALAANRAATLAVL- 109

Query: 169 DEGAQAVAMEVSSHALDQGRVDGVHYDVVVFTNLTRDHLDYHGDMEHYGAAKARLFAHQD 228
               +   M V   A      D +   +VV  NL+RD LD  G++           A   
Sbjct: 110 ----EVDEMHVPRVA------DALTPHIVVLLNLSRDQLDRVGEINVIERTLRTGLARHP 159

Query: 229 VQAAVINVDD 238
               + N DD
Sbjct: 160 TAVVIANCDD 169


>gi|2498607|sp|Q49617|NADB_MYCLE PROBABLE L-ASPARTATE OXIDASE
           (QUINOLINATE SYNTHETASE B) >gi|2145871|pir||S72695
           L-aspartate oxidase (EC 1.4.3.16) nadB - Mycobacterium
           leprae >gi|466783 (U00010) L-aspartate oxidase
           (quinolinate synthetase, B protein); nadB;
           Lepb1170_C1_167 [Mycobacterium leprae]
           Length = 424
           
 Score = 32.8 bits (73), Expect = 6.6
 Identities = 26/104 (25%), Positives = 40/104 (38%), Gaps = 6/104 (5%)

Query: 394 VIAESNADVVFVTDDNPRGEDGDGIVADILAGFARPNVVKVQRDRSAAIAAAIGIASAED 453
           ++A      ++    NP G  GDGI   + AG A  ++  +Q   +   AA  G      
Sbjct: 191 ILASGGLGHLYGATTNPEGSTGDGIALALWAGVAVSDLEFIQFHPTMLFAAGTGTGGRRP 250

Query: 454 VVLIAGKGH------ERYQEVAGVRHPFDDTEVARRVLAAMSAQ 491
           +V  A +G        +   V    HP  D      V AA+ A+
Sbjct: 251 LVTEAIRGEGAILLDSKGNSVTSGVHPLGDLAPRDVVAAAIDAR 294


>gi|2570172|dbj|BAA22971| (D63452) alchohol dehydrogenase [Arabis
           gemmifera]
           Length = 379
           
 Score = 32.8 bits (73), Expect = 6.6
 Identities = 37/134 (27%), Positives = 57/134 (41%), Gaps = 19/134 (14%)

Query: 7   LAQLLPDIPQARDVVIS-------GLVMDSREVQPGDAFVAVAGFGAHGLCFIEDACARG 59
           +A++ PD P  +  ++S       G  ++  + + G + VA+ G GA GL   E A   G
Sbjct: 160 VAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPRKGQS-VAIFGLGAVGLAAAEGARIAG 218

Query: 60  AVAILFEPPAPQGVSVPDGAIAVHGLRARLGAMADRFHGHPSQ----AMTMVGVTGTNGK 115
           A  I+       GV +     A          +  R HG P Q     MT  GV  +   
Sbjct: 219 ASRII-------GVDLNSQRFAQAKEFGVTEFVNPRDHGKPVQQVIAEMTNGGVDRSVEC 271

Query: 116 TSTVQLLAQAWHCL 129
           T +VQ + QA+ C+
Sbjct: 272 TGSVQAMIQAFECV 285


>gi|4155222 (AE001499) D-ALANYL-D-ALANINE-ADDING ENZYME
           [Helicobacter pylori J99]
           Length = 493
           
 Score = 32.8 bits (73), Expect = 6.6
 Identities = 19/88 (21%), Positives = 41/88 (46%), Gaps = 2/88 (2%)

Query: 264 DADVMAQHLSLNLQGIGFDLVIGADHASVRSPLMGRFNVDNLLAVAGVLYALNYALSEIA 323
           D   + +++   L+G  F+ +I     S  + ++G FN  N+ +   +   L      I 
Sbjct: 303 DYSSLVRNVQSTLKGTSFETLINGVWESFETKVLGEFNAYNIASAILIAKHLGLETERIK 362

Query: 324 AVLSTLRPIHGRMNRLGGQDGQPVVVVD 351
            ++  L+PI+ R+  L  +  Q +++ D
Sbjct: 363 RLVFELKPINHRLQLL--EANQKIIIDD 388


>gi|3798624 (AF082100) FK506 polyketide synthase [Streptomyces sp.
           MA6548]
           Length = 7576
           
 Score = 32.5 bits (72), Expect = 8.6
 Identities = 29/98 (29%), Positives = 45/98 (45%), Gaps = 4/98 (4%)

Query: 26  VMDSREVQPGDAFVAVAGFGAHGLCFIEDACARGAVAILFEPPAPQGVSVPDGAIAVHGL 85
           ++D+ +V+PG   +  A  G  G    + A   GA       PA Q + + DG  A H  
Sbjct: 758 LVDAGQVRPGQKVLIHAATGGVGSAARQIARHMGADVYATASPAKQHLLLADGFDADHVA 817

Query: 86  RARLGAMADRFHGHPSQAMTMVGVTGTNGKTSTVQLLA 123
            +R  A AD F   P   + +  +TG     ++V+LLA
Sbjct: 818 NSRTTAFADAF---PPVDVVLNSLTG-EFLDASVELLA 851


  Database: nr
    Posted date:  Feb 20, 2000 12:20 AM
  Number of letters in database: 140,871,481
  Number of sequences in database:  457,798
  
Lambda     K      H
   0.322    0.138    0.407 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 131835078
Number of Sequences: 457798
Number of extensions: 5481913
Number of successful extensions: 13153
Number of sequences better than 10.0: 105
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 12892
Number of HSP's gapped (non-prelim): 146
length of query: 495
length of database: 140,871,481
effective HSP length: 55
effective length of query: 440
effective length of database: 115,692,591
effective search space: 50904740040
effective search space used: 50904740040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 72 (32.5 bits)