| Strongest similarity (2e-94) to
Neisseria meningitidis IRON-REGULATED
PROTEIN FRPC (sp|P55127|FRPC_NEIME),
also known as cytotoxin RTX homolog
frpC (gi|420920|pir||S35027). There are
also BLAST hits to the FRPA protein of
the same organism (9e-72,
sp|P55126|FRPA_NEIME) and to two
proteins of Actinobacillus
pleuropneumoniae: RTX protein (4e-72,
gb|AAD01698.1| (AF021919)) and ApxIVA
var3 (9e-62, gb|AAD01905.1| (AF030511))
which are similar to N. meningitidis
FRPC protein. There are several other
good BLAST hits to the final half of
this CDS which are mainly adenylate
cyclase hemolysins of different
organisms.The main reason for these
matches may be the high number of
repetitive glycine-rich regions which
are probably involved in Calcium
binding as pointed by the comments for
the N. meningitidis FRPC
protein:[FUNCTION] MAY PARTICIPATE IN
THE PATHOGENESIS OF MENINGOCOCCAL
DISEASE.[SUBCELLULAR LOCATION]
OUTER-MEMBRANE ASSOCIATED AND
SECRETED.[DOMAIN] THE GLY-RICH REGION
IS PROBABLY INVOLVED IN BINDING
CALCIUM, WHICH IS REQUIRED FOR TARGET
CELL-BINDING OR CYTOLYTIC
ACTIVITY.[SIMILARITY] TO OTHER
HEMOLYSINS OF THE RTX FAMILY (REPEAT IN
THE STRUCTURAL TOXIN). Note: there are
43 X repeats, Gly-rich. As Xylella
fastidiosa is a phytophatogen it was
decided to classify this CDS as a
putative cytolic protein rather than a
putative hemolysin
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