| Strongest similarity (e-148) to
Pseudomonas aeruginosa (pir||S54872)
penicillin-binding protein 3. Also
similar (e-129) to Escherichia coli
(sp|P04286|) PENICILLIN-BINDING PROTEIN
3 PRECURSOR (PBP-3). The E.coli
comments are: '[FUNCTION] CELL WALL
FORMATION. PBP3 IS ESSENTIAL FOR THE
FORMATION OF A SEPTUM OF THE MUREIN
SACCULUS. THE BULK OF THE MOLECULE,
EXCEPT FOR THE N-TERMINAL MEMBRANE
ANCHOR REGION, PROTRUDES INTO THE
PERIPLASMIC SPACE, WHERE IT ACTS ON
MUREIN. [CATALYTIC ACTIVITY] SYNTHESIS
OF CROSS-LINKED PEPTIDOGLYCAN FROM THE
LIPID INTERMEDIATES. THE ENZYME HAS AN
N-TERMINAL PENICILLIN INSENSITIVE
TRANGLYCOSYLASE DOMAIN (FORMATION OF
LINEAR GLYCAN STRANDS) & A
CARBOXY-TERMINAL PENICILLIN-SENSITIVE
TRANSPEPTIDASE DOMAIN (CROSS-LINKING OF
THE PEPTIDE SUBUNITS). [PATHWAY] FINAL
STAGES IN PEPTIDOGLYCANSYNTHESIS.
[SUBCELLULAR LOCATION] INNER MEMBRANE.
MUTANT PBPBR1 WHICH WAS OBTAINED AFTER
SELECTION FOR INCREASED RESISTANCE TO
CEPHALEXIN, CAUSES A CHANGE IN THE
SHAPE OF THE CELL: THE POLAR CAPS ARE
POINTED. [SIMILARITY] MAY BE THE
FUNCTIONAL HOMOLOGUE OF B.SUBTILIS
PBP-2B'
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