| Similar to several spp. GDP-D-mannose
dehydratase (EC 4.2.1.47). Strongest
(e-117) similarity to Aquifex aeolicus
GDP-D-mannose dehydratase (gi|2983560).
Also similar (1e-95) to E.coli
GDP-D-mannose dehydratase
(sp|P32054|GM4D_ECOLI, gmd gene) whose
comments are:'[FUNCTION] INVOLVED IN
THE BIOSYNTHESIS OF THE SLIME
POLYSACCHARIDE COLANIC ACID.[CATALYTIC
ACTIVITY] GDP-MANNOSE =
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE +
H(2)O.[COFACTOR] NADP(+).[SUBUNIT]
HOMOHEXAMER.[SIMILARITY] STRONG, TO
OTHER GDP-MANNOSE 4,6-DEHYDRATASE. ALSO
SIMILAR TO DTDP-GLUCOSE
4,6-DEHYDRATASES.' The COGnitor
analysis included the translational
product of this ORF in COG1089 (7) -
GDP-D-mannose dehydratase. The Pfam
analysis determined a NAD dependent
epimerase/dehydratase family motif
(4.3e-10) from aa 6 to 340
| | |