| The most similar, but partial, BLASTp
hit (6e-28) is to Pseudomonas
aeruginosa oxidoreductase Rmd
(gi|3249547 (AF009955)), which is
described as a putative oxidoreductase
converting GDP-4-keto-6-deoxy-mannose
to GDP-D-rhamnose. Similar to several
UDP-glucose 4-epimerase (EC 5.1.3.2)
from different species. Among them the
best hit is Azospirillum brasilense
UDP-glucose 4-epimerase (1e-21,
gi|604222 (U09349)). Other significant
BLASTp hits are to Deinococcus
radiodurans UDP-glucose 4-epimerase,
putative (1e-19,
gi|6458415|gb|AAF10287.1|AE001927_6
(AE001927)) and Brevibacterium
lactofermentum UDP-GLUCOSE 4-EPIMERASE
(GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) (2e-17,
sp|Q45291|GALE_BRELA), among others.
The comments for the B. lactofermentum
protein are: [CATALYTIC ACTIVITY]
UDP-GLUCOSE = UDP-GALACTOSE. [COFACTOR]
NAD. [PATHWAY] GALACTOSE METABOLISM.
[SUBUNIT] HOMODIMER (BY SIMILARITY).
[SIMILARITY] WITH OTHER
GALACTOWALDENASES FROM EUKARYOTIC AND
PROKARYOTIC ORIGIN. There are also many
BLASTp hits to (d)NDP-sugar
dehydratases. The COGnitor analysis
included the translational product of
this ORF in COG0451 (6) -
Nucleoside-diphosphate-sugar
epimerases. The Pfam analysis
determined a NAD dependent
epimerase/dehydratase family protein
motif (3.5e-15) from aa 28 to 323 of
the tranlational product of this ORF
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